Association of IL-1β, IL-6, TNF-α, and TGFβ1 Gene Polymorphisms with Recurrent Spontaneous Abortion in Polycystic Ovary Syndrome
Recurrent spontaneous abortion (RSA) is a common pregnancy-associated complication of polycystic ovary syndrome (PCOS) which is an endocrine malfunction disease. Patients with PCOS may have several underlying contributing and interrelated factors, which have been reported in women with RSA. The inci...
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| Published in | Disease markers Vol. 2020; no. 2020; pp. 1 - 8 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Cairo, Egypt
Hindawi Publishing Corporation
2020
Hindawi John Wiley & Sons, Inc |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0278-0240 1875-8630 1875-8630 |
| DOI | 10.1155/2020/6076274 |
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| Abstract | Recurrent spontaneous abortion (RSA) is a common pregnancy-associated complication of polycystic ovary syndrome (PCOS) which is an endocrine malfunction disease. Patients with PCOS may have several underlying contributing and interrelated factors, which have been reported in women with RSA. The incidence rate between PCOS and RSA remains uncertain. The aim of this study is to determine the possible association of IL-1β-511C/T, IL-6-174G/C, TNF-α-1031T/C, and TGFβ1-509T/C with RSA patients with or without PCOS. A total of 140 RSA patients, 70 of which were PCOS patients, and 140 healthy females with no history of RSA or PCOS were included in this study. PCR amplification, genotyping, and sequence analysis were employed to investigate the presence of the polymorphisms. The genotypic and allelic frequencies were calculated separately for each subject. Out of the four studied polymorphisms, the IL-1β-511C/T genotype in RSA without PCOS patients (12.7%) was significantly different compared with that in control subjects (p=0.047). For IL-6-174C/G, there was a tendency towards more CC carriers among RSA with PCOS patients (10%) than in controls (3%). The GG genotype in RSA women with PCOS (60%) was significantly different compared with that in control subjects (p=0.033), and the GC genotype in RSA with PCOS patients (30%) showed a marginal significant difference compared with that in control subjects (p=0.050). Significant difference was identified in the allelic frequencies in RSA patients with PCOS compared to controls (p=0.025). IL-6-174G/C and TNF-α-1031T/C polymorphisms are significantly associated with RSA patients in Saudi patients with PCOS, while the IL-1β-511C/T polymorphism is significantly associated with RSA patients without PCOS. |
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| AbstractList | Recurrent spontaneous abortion (RSA) is a common pregnancy-associated complication of polycystic ovary syndrome (PCOS) which is an endocrine malfunction disease. Patients with PCOS may have several underlying contributing and interrelated factors, which have been reported in women with RSA. The incidence rate between PCOS and RSA remains uncertain. The aim of this study is to determine the possible association of IL-1β-511C/T, IL-6-174G/C, TNF-α-1031T/C, and TGFβ1-509T/C with RSA patients with or without PCOS. A total of 140 RSA patients, 70 of which were PCOS patients, and 140 healthy females with no history of RSA or PCOS were included in this study. PCR amplification, genotyping, and sequence analysis were employed to investigate the presence of the polymorphisms. The genotypic and allelic frequencies were calculated separately for each subject. Out of the four studied polymorphisms, the IL-1β-511C/T genotype in RSA without PCOS patients (12.7%) was significantly different compared with that in control subjects (p=0.047). For IL-6-174C/G, there was a tendency towards more CC carriers among RSA with PCOS patients (10%) than in controls (3%). The GG genotype in RSA women with PCOS (60%) was significantly different compared with that in control subjects (p=0.033), and the GC genotype in RSA with PCOS patients (30%) showed a marginal significant difference compared with that in control subjects (p=0.050). Significant difference was identified in the allelic frequencies in RSA patients with PCOS compared to controls (p=0.025). IL-6-174G/C and TNF-α-1031T/C polymorphisms are significantly associated with RSA patients in Saudi patients with PCOS, while the IL-1β-511C/T polymorphism is significantly associated with RSA patients without PCOS. Recurrent spontaneous abortion (RSA) is a common pregnancy-associated complication of polycystic ovary syndrome (PCOS) which is an endocrine malfunction disease. Patients with PCOS may have several underlying contributing and interrelated factors, which have been reported in women with RSA. The incidence rate between PCOS and RSA remains uncertain. The aim of this study is to determine the possible association of IL-1β -511C/T, IL-6 -174G/C, TNF-α -1031T/C, and TGFβ1 -509T/C with RSA patients with or without PCOS. A total of 140 RSA patients, 70 of which were PCOS patients, and 140 healthy females with no history of RSA or PCOS were included in this study. PCR amplification, genotyping, and sequence analysis were employed to investigate the presence of the polymorphisms. The genotypic and allelic frequencies were calculated separately for each subject. Out of the four studied polymorphisms, the IL-1β -511C/T genotype in RSA without PCOS patients (12.7%) was significantly different compared with that in control subjects ( p = 0.047). For IL-6 -174C/G, there was a tendency towards more CC carriers among RSA with PCOS patients (10%) than in controls (3%). The GG genotype in RSA women with PCOS (60%) was significantly different compared with that in control subjects ( p = 0.033), and the GC genotype in RSA with PCOS patients (30%) showed a marginal significant difference compared with that in control subjects ( p = 0.050). Significant difference was identified in the allelic frequencies in RSA patients with PCOS compared to controls ( p = 0.025). IL-6 -174G/C and TNF-α -1031T/C polymorphisms are significantly associated with RSA patients in Saudi patients with PCOS, while the IL-1β -511C/T polymorphism is significantly associated with RSA patients without PCOS. Recurrent spontaneous abortion (RSA) is a common pregnancy-associated complication of polycystic ovary syndrome (PCOS) which is an endocrine malfunction disease. Patients with PCOS may have several underlying contributing and interrelated factors, which have been reported in women with RSA. The incidence rate between PCOS and RSA remains uncertain. The aim of this study is to determine the possible association of IL-1β-511C/T, IL-6-174G/C, TNF-α-1031T/C, and TGFβ1-509T/C with RSA patients with or without PCOS. A total of 140 RSA patients, 70 of which were PCOS patients, and 140 healthy females with no history of RSA or PCOS were included in this study. PCR amplification, genotyping, and sequence analysis were employed to investigate the presence of the polymorphisms. The genotypic and allelic frequencies were calculated separately for each subject. Out of the four studied polymorphisms, the IL-1β-511C/T genotype in RSA without PCOS patients (12.7%) was significantly different compared with that in control subjects (p = 0.047). For IL-6-174C/G, there was a tendency towards more CC carriers among RSA with PCOS patients (10%) than in controls (3%). The GG genotype in RSA women with PCOS (60%) was significantly different compared with that in control subjects (p = 0.033), and the GC genotype in RSA with PCOS patients (30%) showed a marginal significant difference compared with that in control subjects (p = 0.050). Significant difference was identified in the allelic frequencies in RSA patients with PCOS compared to controls (p = 0.025). IL-6-174G/C and TNF-α-1031T/C polymorphisms are significantly associated with RSA patients in Saudi patients with PCOS, while the IL-1β-511C/T polymorphism is significantly associated with RSA patients without PCOS.Recurrent spontaneous abortion (RSA) is a common pregnancy-associated complication of polycystic ovary syndrome (PCOS) which is an endocrine malfunction disease. Patients with PCOS may have several underlying contributing and interrelated factors, which have been reported in women with RSA. The incidence rate between PCOS and RSA remains uncertain. The aim of this study is to determine the possible association of IL-1β-511C/T, IL-6-174G/C, TNF-α-1031T/C, and TGFβ1-509T/C with RSA patients with or without PCOS. A total of 140 RSA patients, 70 of which were PCOS patients, and 140 healthy females with no history of RSA or PCOS were included in this study. PCR amplification, genotyping, and sequence analysis were employed to investigate the presence of the polymorphisms. The genotypic and allelic frequencies were calculated separately for each subject. Out of the four studied polymorphisms, the IL-1β-511C/T genotype in RSA without PCOS patients (12.7%) was significantly different compared with that in control subjects (p = 0.047). For IL-6-174C/G, there was a tendency towards more CC carriers among RSA with PCOS patients (10%) than in controls (3%). The GG genotype in RSA women with PCOS (60%) was significantly different compared with that in control subjects (p = 0.033), and the GC genotype in RSA with PCOS patients (30%) showed a marginal significant difference compared with that in control subjects (p = 0.050). Significant difference was identified in the allelic frequencies in RSA patients with PCOS compared to controls (p = 0.025). IL-6-174G/C and TNF-α-1031T/C polymorphisms are significantly associated with RSA patients in Saudi patients with PCOS, while the IL-1β-511C/T polymorphism is significantly associated with RSA patients without PCOS. Recurrent spontaneous abortion (RSA) is a common pregnancy-associated complication of polycystic ovary syndrome (PCOS) which is an endocrine malfunction disease. Patients with PCOS may have several underlying contributing and interrelated factors, which have been reported in women with RSA. The incidence rate between PCOS and RSA remains uncertain. The aim of this study is to determine the possible association of -511C/T, -174G/C, -1031T/C, and -509T/C with RSA patients with or without PCOS. A total of 140 RSA patients, 70 of which were PCOS patients, and 140 healthy females with no history of RSA or PCOS were included in this study. PCR amplification, genotyping, and sequence analysis were employed to investigate the presence of the polymorphisms. The genotypic and allelic frequencies were calculated separately for each subject. Out of the four studied polymorphisms, the -511C/T genotype in RSA without PCOS patients (12.7%) was significantly different compared with that in control subjects ( = 0.047). For -174C/G, there was a tendency towards more CC carriers among RSA with PCOS patients (10%) than in controls (3%). The GG genotype in RSA women with PCOS (60%) was significantly different compared with that in control subjects ( = 0.033), and the GC genotype in RSA with PCOS patients (30%) showed a marginal significant difference compared with that in control subjects ( = 0.050). Significant difference was identified in the allelic frequencies in RSA patients with PCOS compared to controls ( = 0.025). -174G/C and -1031T/C polymorphisms are significantly associated with RSA patients in Saudi patients with PCOS, while the -511C/T polymorphism is significantly associated with RSA patients without PCOS. Recurrent spontaneous abortion (RSA) is a common pregnancy-associated complication of polycystic ovary syndrome (PCOS) which is an endocrine malfunction disease. Patients with PCOS may have several underlying contributing and interrelated factors, which have been reported in women with RSA. The incidence rate between PCOS and RSA remains uncertain. The aim of this study is to determine the possible association of IL-1β -511C/T, IL-6 -174G/C, TNF-α -1031T/C, and TGFβ1 -509T/C with RSA patients with or without PCOS. A total of 140 RSA patients, 70 of which were PCOS patients, and 140 healthy females with no history of RSA or PCOS were included in this study. PCR amplification, genotyping, and sequence analysis were employed to investigate the presence of the polymorphisms. The genotypic and allelic frequencies were calculated separately for each subject. Out of the four studied polymorphisms, the IL-1β -511C/T genotype in RSA without PCOS patients (12.7%) was significantly different compared with that in control subjects ( p = 0.047 ). For IL-6 -174C/G, there was a tendency towards more CC carriers among RSA with PCOS patients (10%) than in controls (3%). The GG genotype in RSA women with PCOS (60%) was significantly different compared with that in control subjects ( p = 0.033 ), and the GC genotype in RSA with PCOS patients (30%) showed a marginal significant difference compared with that in control subjects ( p = 0.050 ). Significant difference was identified in the allelic frequencies in RSA patients with PCOS compared to controls ( p = 0.025 ). IL-6 -174G/C and TNF-α -1031T/C polymorphisms are significantly associated with RSA patients in Saudi patients with PCOS, while the IL-1β -511C/T polymorphism is significantly associated with RSA patients without PCOS. |
| Author | Babay, Zainb A. El-khadragy, Manal F. Al Omar, Suliman Y. al-Khurayji, Afrah Fahd Khalil, Mahmoud I. Alharbi, Wazirah G. Mansour, Lamjed A. |
| AuthorAffiliation | 2 Department of Obstetrics and Gynaecology, King Saud University, King Khalid University Hospital, Riyadh, Saudi Arabia 5 Faculty of Sciences of Gabès, University of Gabès, Erriadh City 6072, Zrig Gabès, Tunisia 4 Department of Zoology and Entomology, College of Science, Helwan University, Cairo, Egypt 3 Department of Biology, Faculty of Science, Princess Nourah Bint Abdulrahman University, Saudi Arabia 6 Department of Biological Sciences, Faculty of Science, Beirut Arab University, Lebanon 1 Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia 7 Molecular Biology Unit, Department of Zoology, Faculty of Science, Alexandria University, Egypt |
| AuthorAffiliation_xml | – name: 1 Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia – name: 7 Molecular Biology Unit, Department of Zoology, Faculty of Science, Alexandria University, Egypt – name: 3 Department of Biology, Faculty of Science, Princess Nourah Bint Abdulrahman University, Saudi Arabia – name: 6 Department of Biological Sciences, Faculty of Science, Beirut Arab University, Lebanon – name: 2 Department of Obstetrics and Gynaecology, King Saud University, King Khalid University Hospital, Riyadh, Saudi Arabia – name: 4 Department of Zoology and Entomology, College of Science, Helwan University, Cairo, Egypt – name: 5 Faculty of Sciences of Gabès, University of Gabès, Erriadh City 6072, Zrig Gabès, Tunisia |
| Author_xml | – sequence: 1 fullname: Khalil, Mahmoud I. – sequence: 2 fullname: Mansour, Lamjed A. – sequence: 3 fullname: El-khadragy, Manal F. – sequence: 4 fullname: Babay, Zainb A. – sequence: 5 fullname: Al Omar, Suliman Y. – sequence: 6 fullname: al-Khurayji, Afrah Fahd – sequence: 7 fullname: Alharbi, Wazirah G. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32454906$$D View this record in MEDLINE/PubMed |
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| Copyright | Copyright © 2020 Afrah F. Alkhuriji et al. Copyright © 2020 Afrah F. Alkhuriji et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0 Copyright © 2020 Afrah F. Alkhuriji et al. 2020 |
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| Snippet | Recurrent spontaneous abortion (RSA) is a common pregnancy-associated complication of polycystic ovary syndrome (PCOS) which is an endocrine malfunction... |
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| SubjectTerms | Abortion, Habitual - blood Abortion, Habitual - diagnosis Abortion, Habitual - genetics Abortion, Habitual - physiopathology Adolescent Adult Age Alleles Body mass index Cardiovascular disease Case-Control Studies Cytokines Deoxyribonucleic acid DNA Equilibrium Expected values Female Gene Expression Gene Frequency Gene polymorphism Genes Genetic testing Genotype Genotype & phenotype Genotyping Gynecology Hospitals Humans IL-1β Insulin resistance Interleukin 6 Interleukin-1beta - blood Interleukin-1beta - genetics Interleukin-6 - blood Interleukin-6 - genetics Medical ethics Middle Aged Miscarriage Mutation Obesity Obstetrics Outpatient care facilities Polycystic ovary syndrome Polycystic Ovary Syndrome - blood Polycystic Ovary Syndrome - diagnosis Polycystic Ovary Syndrome - genetics Polycystic Ovary Syndrome - physiopathology Polymorphism Polymorphism, Single Nucleotide Pregnancy Promoter Regions, Genetic Sequence analysis Transforming Growth Factor beta1 - blood Transforming Growth Factor beta1 - genetics Transforming growth factor-b1 Tumor Necrosis Factor-alpha - blood Tumor Necrosis Factor-alpha - genetics Tumor necrosis factor-TNF Tumor necrosis factor-α Variance analysis Womens health |
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| Title | Association of IL-1β, IL-6, TNF-α, and TGFβ1 Gene Polymorphisms with Recurrent Spontaneous Abortion in Polycystic Ovary Syndrome |
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