Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro
Stimulation of epidermal growth factor receptor (EGFR) by ligand(s) leads to activation of signaling molecules including Stat1 and Stat3, two members of the signal transducers and activators of transcription (STAT) protein family. Activation of Stat1 and Stat3 was constitutive in transformed squamou...
Saved in:
| Published in | The Journal of clinical investigation Vol. 102; no. 7; pp. 1385 - 1392 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
01.10.1998
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Stimulation of epidermal growth factor receptor (EGFR) by ligand(s) leads to activation of signaling molecules including Stat1 and Stat3, two members of the signal transducers and activators of transcription (STAT) protein family. Activation of Stat1 and Stat3 was constitutive in transformed squamous epithelial cells, which produce elevated levels of TGF-alpha, and was enhanced by the addition of exogenous TGF-alpha. Targeting of Stat3 using antisense oligonucleotides directed against the translation initiation site, resulted in significant growth inhibition. In addition, cells stably transfected with dominant negative mutant Stat3 constructs failed to proliferate in vitro. In contrast, targeting of Stat1 using either antisense or dominant-negative strategies had no effect on cell growth. Thus, TGF-alpha/EGFR-mediated autocrine growth of transformed epithelial cells is dependent on activation of Stat3 but not Stat1. |
|---|---|
| AbstractList | Stimulation of epidermal growth factor receptor (EGFR) by ligand(s) leads to activation of signaling molecules including Stat1 and Stat3, two members of the signal transducers and activators of transcription (STAT) protein family. Activation of Stat1 and Stat3 was constitutive in transformed squamous epithelial cells, which produce elevated levels of TGF-alpha, and was enhanced by the addition of exogenous TGF-alpha. Targeting of Stat3 using antisense oligonucleotides directed against the translation initiation site, resulted in significant growth inhibition. In addition, cells stably transfected with dominant negative mutant Stat3 constructs failed to proliferate in vitro. In contrast, targeting of Stat1 using either antisense or dominant-negative strategies had no effect on cell growth. Thus, TGF-alpha/EGFR-mediated autocrine growth of transformed epithelial cells is dependent on activation of Stat3 but not Stat1. |
| Author | Zhou, M Y Grandis, J R Chakraborty, A Pitt, A S Drenning, S D Zeng, Q Tweardy, D J |
| AuthorAffiliation | Department of Otolaryngology, University of Pittsburgh School of Medicine and the University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA. jgrandis@vms.cis.pitt.edu |
| AuthorAffiliation_xml | – name: Department of Otolaryngology, University of Pittsburgh School of Medicine and the University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA. jgrandis@vms.cis.pitt.edu |
| Author_xml | – sequence: 1 givenname: J R surname: Grandis fullname: Grandis, J R email: jgrandis@vms.cis.pitt.edu organization: Department of Otolaryngology, University of Pittsburgh School of Medicine and the University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA. jgrandis@vms.cis.pitt.edu – sequence: 2 givenname: S D surname: Drenning fullname: Drenning, S D – sequence: 3 givenname: A surname: Chakraborty fullname: Chakraborty, A – sequence: 4 givenname: M Y surname: Zhou fullname: Zhou, M Y – sequence: 5 givenname: Q surname: Zeng fullname: Zeng, Q – sequence: 6 givenname: A S surname: Pitt fullname: Pitt, A S – sequence: 7 givenname: D J surname: Tweardy fullname: Tweardy, D J |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/9769331$$D View this record in MEDLINE/PubMed |
| BookMark | eNpVkclOwzAQhn0AQVnEEyD5BKeAJ7bj5MABVSxFlZBYzpbjTFqjJm4dp4i3J9CqgtNs32z6j8he61sk5AzYFYBKr5_GE65yuUdGjKWQFIrnh-So6z4YAyGkOCAHhcoKzmFEVi-46l3ABttIfU1fo4mcln2krY-_EVBjo1ub6HxLax8oLl2FoTELOgv-M85pPQBDPqDF5eAktMHKmYgVtbjYUZOWrl0M_oTs12bR4enWHpP3-7u38WMyfX6YjG-niRUMYiK5RBB1yUsAqMoyA5nlqRCpAiskRyszYYtS8SIHpWwm06xkqHKljFUVWH5MbjZzl305HGSHB4NZ6GVwjQlf2hun_1daN9czv9aS5UWeDf0X2_7gVz12UTeu-3nItOj7TmdFISUwNoCXG9AG33UB690OYPpHEL0VZCDP_56047Zq8G-h1IsM |
| CitedBy_id | crossref_primary_10_1016_j_yexcr_2008_08_009 crossref_primary_10_1074_jbc_M106044200 crossref_primary_10_1593_neo_04571 crossref_primary_10_1093_annonc_mdu156 crossref_primary_10_1038_onc_2016_271 crossref_primary_10_1158_1940_6207_CAPR_14_0136 crossref_primary_10_1016_S0304_3835_00_00623_6 crossref_primary_10_1186_bcr38 crossref_primary_10_1371_journal_pone_0015945 crossref_primary_10_4161_onci_27215 crossref_primary_10_1007_s12272_022_01398_y crossref_primary_10_1016_j_ijrobp_2003_09_095 crossref_primary_10_1016_j_canlet_2012_11_052 crossref_primary_10_1038_nrclinonc_2018_8 crossref_primary_10_1007_s12029_013_9555_x crossref_primary_10_1053_j_seminoncol_2010_06_014 crossref_primary_10_1155_2011_982879 crossref_primary_10_1186_1476_4598_5_15 crossref_primary_10_1038_sj_onc_1203483 crossref_primary_10_1158_2159_8290_CD_13_0103 crossref_primary_10_1016_j_ijrobp_2009_07_1731 crossref_primary_10_1097_00005392_200208000_00095 crossref_primary_10_1073_pnas_98_4_1543 crossref_primary_10_1002_lary_21044 crossref_primary_10_1371_journal_pone_0061716 crossref_primary_10_1371_journal_pone_0031884 crossref_primary_10_1016_j_semcancer_2019_10_002 crossref_primary_10_1038_sj_onc_1206523 crossref_primary_10_1074_jbc_M301629200 crossref_primary_10_1016_j_oraloncology_2015_11_022 crossref_primary_10_1016_j_cellsig_2009_02_021 crossref_primary_10_2310_JIM_0b013e318292110a crossref_primary_10_1007_s11060_015_1731_3 crossref_primary_10_1016_j_biomaterials_2009_11_003 crossref_primary_10_1158_1541_7786_MCR_08_0095 crossref_primary_10_2298_SARH0902098K crossref_primary_10_1006_bbrc_1999_0684 crossref_primary_10_1016_j_pharmthera_2004_01_002 crossref_primary_10_1111_j_1745_7254_2005_00053_x crossref_primary_10_1016_j_cellsig_2013_07_023 crossref_primary_10_1038_nrc2734 crossref_primary_10_1002_stem_170138 crossref_primary_10_1016_S0171_2985_00_80061_3 crossref_primary_10_1074_jbc_M609798200 crossref_primary_10_1158_1535_7163_1533_3_12 crossref_primary_10_3892_mmr_2015_3716 crossref_primary_10_1002_jcp_22767 crossref_primary_10_1038_sj_onc_1208719 crossref_primary_10_1007_BF03403538 crossref_primary_10_1006_cimm_2000_1661 crossref_primary_10_1016_j_leukres_2017_09_022 crossref_primary_10_1021_bi052490j crossref_primary_10_1016_j_canlet_2015_07_009 crossref_primary_10_1038_sj_onc_1203829 crossref_primary_10_1016_j_gpb_2019_09_008 crossref_primary_10_3109_07853890_2014_882105 crossref_primary_10_1038_sj_onc_1203947 crossref_primary_10_1530_ERC_13_0054 crossref_primary_10_1016_j_prp_2023_154760 crossref_primary_10_3748_wjg_v9_i2_271 crossref_primary_10_1158_0008_5472_CAN_13_2329 crossref_primary_10_1517_14728222_8_5_409 crossref_primary_10_1016_j_molonc_2016_03_001 crossref_primary_10_1016_S0304_3835_03_00345_8 crossref_primary_10_1111_j_1346_8138_2010_00827_x crossref_primary_10_1158_2159_8290_CD_11_0218 crossref_primary_10_1371_journal_pone_0059798 crossref_primary_10_1200_JCO_2008_17_8251 crossref_primary_10_1016_S1050_1738_01_00066_4 crossref_primary_10_1158_1055_9965_EPI_08_0089 crossref_primary_10_3892_or_2014_3114 crossref_primary_10_1016_j_bmcl_2007_10_031 crossref_primary_10_1182_blood_2010_04_280123 crossref_primary_10_1016_j_jmb_2007_12_038 crossref_primary_10_1038_sj_bjc_6602055 crossref_primary_10_1007_s10822_007_9147_6 crossref_primary_10_1016_j_clcc_2012_09_002 crossref_primary_10_1002_jcb_10145 crossref_primary_10_1007_s13167_019_00177_y crossref_primary_10_1046_j_1523_1755_2002_00206_x crossref_primary_10_1038_s41467_017_01885_7 crossref_primary_10_1038_nri1995 crossref_primary_10_1371_journal_pone_0024071 crossref_primary_10_1111_eva_13240 crossref_primary_10_1186_s12885_015_1679_x crossref_primary_10_1002_jcb_21272 crossref_primary_10_2217_imt_12_135 crossref_primary_10_1158_1078_0432_CCR_07_4923 crossref_primary_10_1196_annals_1378_063 crossref_primary_10_4049_jimmunol_166_12_7486 crossref_primary_10_1002_smll_202107712 crossref_primary_10_1158_1078_0432_CCR_0714_3 crossref_primary_10_1038_s12276_020_00551_1 crossref_primary_10_1096_fj_02_0597com crossref_primary_10_1158_1078_0432_CCR_10_0333 crossref_primary_10_1016_j_ejcb_2007_05_009 crossref_primary_10_1111_apm_12407 crossref_primary_10_1016_j_canlet_2008_05_035 crossref_primary_10_1021_jm050513m crossref_primary_10_1158_1535_7163_21_3_1 crossref_primary_10_1096_fj_02_1084fje crossref_primary_10_1016_j_jbior_2014_05_004 crossref_primary_10_2337_diabetes_52_9_2381 crossref_primary_10_3390_molecules21121626 crossref_primary_10_1158_1541_7786_170_2_3 crossref_primary_10_1593_neo_09266 crossref_primary_10_1007_s10555_005_5047_1 crossref_primary_10_3389_fcimb_2020_537650 crossref_primary_10_1002_biof_1041 crossref_primary_10_1097_TP_0b013e3181739d25 crossref_primary_10_3892_ijmm_2017_3122 crossref_primary_10_1016_j_bbcan_2012_10_002 crossref_primary_10_1084_jem_20080003 crossref_primary_10_1158_1535_7163_11_3_1 crossref_primary_10_4049_jimmunol_177_12_8381 crossref_primary_10_1158_1078_0432_CCR_09_2658 crossref_primary_10_3389_fimmu_2022_835997 crossref_primary_10_1074_jbc_M606754200 crossref_primary_10_1016_j_bbcan_2013_12_005 crossref_primary_10_1002__SICI_1097_0215_19991112_83_4_564__AID_IJC20_3_0_CO_2_Q crossref_primary_10_1016_j_radonc_2013_08_036 crossref_primary_10_3390_cancers11101419 crossref_primary_10_1074_jbc_M314037200 crossref_primary_10_1111_j_0022_202X_2004_23497_x crossref_primary_10_3390_ijms23147889 crossref_primary_10_1038_sj_onc_1209149 crossref_primary_10_1200_JCO_2005_04_8306 crossref_primary_10_1039_c0mb00268b crossref_primary_10_1016_j_biopha_2019_109659 crossref_primary_10_1016_j_drup_2010_04_001 crossref_primary_10_1038_nrurol_2014_129 crossref_primary_10_1002__SICI_1098_1136_200005_30_3_253__AID_GLIA5_3_0_CO_2_O crossref_primary_10_1128_JVI_77_11_6385_6393_2003 crossref_primary_10_3389_fonc_2016_00024 crossref_primary_10_1200_JCO_2008_20_6235 crossref_primary_10_1111_odi_12766 crossref_primary_10_1074_jbc_275_8_5748 crossref_primary_10_1158_1541_7786_MCR_07_2177 crossref_primary_10_1016_j_radonc_2004_12_018 crossref_primary_10_1016_j_ejphar_2020_173107 crossref_primary_10_1101_sqb_1999_64_425 crossref_primary_10_3390_ijms22020603 crossref_primary_10_1038_sj_bjc_6600618 crossref_primary_10_1038_cr_2008_18 crossref_primary_10_1038_onc_2014_72 crossref_primary_10_1016_S0002_9440_10_63940_5 crossref_primary_10_1007_s11010_005_3696_6 crossref_primary_10_1016_S0303_7207_01_00385_9 crossref_primary_10_4049_jimmunol_177_8_5032 crossref_primary_10_1016_j_ejca_2003_10_016 crossref_primary_10_1002_ijc_28112 crossref_primary_10_1002_jcb_20554 crossref_primary_10_1007_s00432_006_0139_z crossref_primary_10_1016_j_semcancer_2020_03_016 crossref_primary_10_1038_sj_onc_1208635 crossref_primary_10_1016_j_oraloncology_2008_07_011 crossref_primary_10_1016_j_ydbio_2010_05_503 crossref_primary_10_1038_sj_bjc_6603234 crossref_primary_10_1016_j_cyto_2022_155916 crossref_primary_10_1158_1535_7163_MCT_05_0302 crossref_primary_10_2337_diabetes_51_12_3505 crossref_primary_10_3390_cancers16030492 crossref_primary_10_1002_jnr_10110 crossref_primary_10_1126_scisignal_2001083 crossref_primary_10_1517_14728214_2010_497754 crossref_primary_10_1371_journal_pone_0070498 crossref_primary_10_1128_MCB_19_11_7519 crossref_primary_10_1593_neo_06409 crossref_primary_10_1016_j_ejmech_2022_114858 crossref_primary_10_1097_00001622_200105000_00007 crossref_primary_10_1111_j_1365_2133_2005_06951_x crossref_primary_10_1093_jnci_djn470 crossref_primary_10_1158_0008_5472_CAN_06_3075 crossref_primary_10_1002_ijc_21967 crossref_primary_10_3390_molecules20022728 crossref_primary_10_1038_sj_onc_1206109 crossref_primary_10_1038_onc_2017_164 crossref_primary_10_1074_jbc_M113_477786 crossref_primary_10_1007_s12035_016_0103_0 crossref_primary_10_1038_sj_onc_1207437 crossref_primary_10_1080_14756366_2020_1871336 crossref_primary_10_1002_jcb_28131 crossref_primary_10_1021_jf204362n crossref_primary_10_1152_ajpcell_00263_2008 crossref_primary_10_1016_j_bj_2021_06_007 crossref_primary_10_1080_01635581_2010_509538 crossref_primary_10_1158_0008_5472_CAN_07_5115 crossref_primary_10_1158_1078_0432_CCR_11_2486 crossref_primary_10_1006_cyto_2002_1022 crossref_primary_10_1016_j_molcel_2013_07_009 crossref_primary_10_1517_13543784_2015_1020370 crossref_primary_10_1517_14712598_6_3_231 crossref_primary_10_3342_ceo_2015_8_3_275 crossref_primary_10_1016_j_tranon_2020_100919 crossref_primary_10_2119_2003_00001_Wu crossref_primary_10_1080_03639045_2018_1539496 crossref_primary_10_1002_ijc_24567 crossref_primary_10_1038_sj_onc_1205499 crossref_primary_10_1038_onc_2012_260 crossref_primary_10_1016_j_oraloncology_2014_08_013 crossref_primary_10_1093_carcin_bgp211 crossref_primary_10_1038_onc_2016_124 crossref_primary_10_1091_mbc_12_4_931 crossref_primary_10_1007_s40496_015_0049_8 crossref_primary_10_1016_j_phymed_2024_155538 crossref_primary_10_1038_sj_onc_1203527 crossref_primary_10_1016_j_bcp_2006_02_009 crossref_primary_10_1046_j_1523_1755_2003_00133_x crossref_primary_10_1007_PL00022009 crossref_primary_10_1038_sj_onc_1206479 crossref_primary_10_1080_1042819031000116670 crossref_primary_10_1517_14712590902735795 crossref_primary_10_1016_j_lungcan_2015_09_014 crossref_primary_10_1016_j_bbagen_2014_04_019 crossref_primary_10_1016_S1607_551X_09_70569_8 crossref_primary_10_1371_journal_pone_0158440 crossref_primary_10_1038_sj_onc_1205260 crossref_primary_10_1007_s11060_012_0981_6 crossref_primary_10_1158_1078_0432_1190_11_3 crossref_primary_10_3390_life11050423 crossref_primary_10_4155_fso_15_13 crossref_primary_10_1038_sj_onc_1205385 crossref_primary_10_1080_13813450802033958 crossref_primary_10_1080_14728222_2017_1306055 crossref_primary_10_1177_154411130401500505 crossref_primary_10_3390_cancers6010494 crossref_primary_10_1002_hed_10224 crossref_primary_10_1080_07357907_2022_2055050 crossref_primary_10_1186_s12917_015_0505_7 crossref_primary_10_1016_S0014_5793_02_02677_7 crossref_primary_10_1016_j_beha_2013_04_006 crossref_primary_10_1074_jbc_M107527200 crossref_primary_10_1158_1535_7163_MCT_09_0327 crossref_primary_10_3389_fphar_2017_00332 crossref_primary_10_3390_cancers13061251 crossref_primary_10_1016_j_cellsig_2013_01_007 crossref_primary_10_1097_00005537_200005000_00016 crossref_primary_10_1002_ijc_10398 crossref_primary_10_1158_1535_7163_MCT_08_0154 crossref_primary_10_1177_154405910808700104 crossref_primary_10_1182_blood_2009_03_213363 crossref_primary_10_1038_sj_onc_1203650 crossref_primary_10_1074_jbc_M000089200 crossref_primary_10_1371_journal_pone_0024923 crossref_primary_10_1038_sj_onc_1206122 crossref_primary_10_1099_0022_1317_83_7_1651 crossref_primary_10_1016_j_oraloncology_2021_105665 crossref_primary_10_1016_j_ajpath_2012_11_019 crossref_primary_10_1002_1521_1878_200102_23_2_161__AID_BIES1023_3_0_CO_2_0 crossref_primary_10_1002_lary_24700 crossref_primary_10_1158_1535_7163_261_3_3 crossref_primary_10_1158_1535_7163_MCT_05_0069 crossref_primary_10_18632_oncotarget_13527 crossref_primary_10_3892_or_2017_5670 crossref_primary_10_1053_j_seminoncol_2008_03_008 crossref_primary_10_1016_j_jocn_2013_03_006 crossref_primary_10_1111_j_1745_7254_2006_00277_x crossref_primary_10_1172_JCI9940 crossref_primary_10_1007_s10555_005_1580_1 crossref_primary_10_1007_s10989_007_9099_7 crossref_primary_10_1158_1078_0432_CCR_05_0148 crossref_primary_10_1038_nrc1275 crossref_primary_10_1038_onc_2012_188 crossref_primary_10_1016_j_currproblcancer_2004_05_003 crossref_primary_10_1038_sj_onc_1205859 crossref_primary_10_1002_jcp_10364 crossref_primary_10_1007_BF02829454 crossref_primary_10_1074_jbc_M303499200 crossref_primary_10_3892_ijo_2012_1568 crossref_primary_10_1152_ajpgi_00253_2004 crossref_primary_10_1007_s12031_014_0341_4 crossref_primary_10_1016_j_ygyno_2005_05_032 crossref_primary_10_1038_s12276_020_00506_6 crossref_primary_10_1158_1078_0432_CCR_04_2102 crossref_primary_10_1210_en_2013_1933 crossref_primary_10_3390_cancers13153714 crossref_primary_10_1097_00004647_200109000_00007 crossref_primary_10_1038_sj_onc_1204086 crossref_primary_10_1038_sj_onc_1207803 crossref_primary_10_1158_0008_5472_CAN_03_4041 crossref_primary_10_1593_neo_06274 crossref_primary_10_1002_cncr_23615 crossref_primary_10_1038_onc_2009_279 crossref_primary_10_1186_s12986_017_0180_8 crossref_primary_10_1038_ng_3073 crossref_primary_10_1158_0008_5472_CAN_03_3197 crossref_primary_10_3389_fphar_2022_950109 crossref_primary_10_1182_blood_V97_11_3559 crossref_primary_10_1182_blood_2002_04_1204 crossref_primary_10_1158_1535_7163_MCT_11_0072 crossref_primary_10_1016_j_otc_2005_11_003 crossref_primary_10_1016_j_ejca_2021_03_009 crossref_primary_10_3390_cancers15235647 crossref_primary_10_3892_ol_2020_11555 crossref_primary_10_1002_cbin_12112 crossref_primary_10_1177_107327489900600617 crossref_primary_10_1371_journal_pone_0117781 crossref_primary_10_1158_1078_0432_CCR_07_1543 crossref_primary_10_1002_mc_20665 crossref_primary_10_3390_cancers6020926 crossref_primary_10_1172_JCI200421032 crossref_primary_10_1002_hed_21975 crossref_primary_10_1097_00054725_199902000_00007 crossref_primary_10_1074_jbc_M004112200 crossref_primary_10_1158_1078_0432_CCR_06_2582 crossref_primary_10_1016_S0016_5085_03_01064_3 crossref_primary_10_3892_ol_2011_423 crossref_primary_10_1007_s11805_006_0127_8 crossref_primary_10_1016_j_biocel_2020_105777 crossref_primary_10_1182_blood_2006_04_017434 crossref_primary_10_1038_sj_onc_1206966 crossref_primary_10_1093_jnci_djj020 crossref_primary_10_1111_jcmm_13945 crossref_primary_10_1016_S0167_8140_02_00131_7 crossref_primary_10_1002_1097_0320_20010801_44_4_338__AID_CYTO1125_3_0_CO_2_V crossref_primary_10_1177_107327489900600501 crossref_primary_10_1046_j_1523_1755_2002_00283_x crossref_primary_10_1593_tlo_10217 crossref_primary_10_1074_jbc_M500206200 crossref_primary_10_1097_00001622_199911000_00010 crossref_primary_10_1007_s11010_012_1437_1 crossref_primary_10_1158_1078_0432_CCR_04_1752 crossref_primary_10_1038_onc_2015_150 crossref_primary_10_1186_s12964_014_0039_9 crossref_primary_10_3727_096504018X15214994641786 crossref_primary_10_1124_mol_106_032284 crossref_primary_10_1111_j_1749_6632_2009_04911_x crossref_primary_10_1007_s12672_023_00808_x crossref_primary_10_1073_pnas_0534764100 crossref_primary_10_1002_pros_21397 crossref_primary_10_1038_oncsis_2013_18 crossref_primary_10_1093_jnci_djj038 crossref_primary_10_1158_1940_6207_CAPR_10_0249 crossref_primary_10_1038_sj_onc_1207703 crossref_primary_10_1111_j_1349_7006_2002_tb02176_x crossref_primary_10_1016_j_celrep_2022_111390 crossref_primary_10_1046_j_1523_1747_2003_12239_x crossref_primary_10_1507_endocrj_EJ21_0106 crossref_primary_10_1038_onc_2013_45 crossref_primary_10_4049_jimmunol_176_5_2933 crossref_primary_10_1016_S0022_5347_05_64741_6 crossref_primary_10_1073_pnas_97_8_4227 crossref_primary_10_1177_0271678X19830791 crossref_primary_10_1006_cyto_2001_0905 crossref_primary_10_1016_j_rvsc_2005_05_009 crossref_primary_10_1074_jbc_M407094200 crossref_primary_10_1038_sj_leu_2404323 crossref_primary_10_1210_endo_141_7_7551 crossref_primary_10_3892_etm_2011_187 crossref_primary_10_1038_s41388_018_0388_8 crossref_primary_10_1002_ijc_20482 crossref_primary_10_1016_j_intimp_2010_12_006 crossref_primary_10_1002_bip_20901 crossref_primary_10_1016_j_celrep_2014_08_047 crossref_primary_10_1016_j_currproblcancer_2007_04_001 crossref_primary_10_1016_S0531_5565_99_00078_9 crossref_primary_10_1053_gast_2002_37075 crossref_primary_10_1053_j_seminoncol_2004_09_010 crossref_primary_10_1111_j_1478_3231_2011_02631_x crossref_primary_10_3892_ol_2018_9227 crossref_primary_10_1182_blood_2007_11_126680 crossref_primary_10_3389_fonc_2019_00048 crossref_primary_10_1016_S0092_8674_00_81959_5 crossref_primary_10_1016_j_bbamcr_2018_11_016 crossref_primary_10_1074_jbc_275_3_2147 crossref_primary_10_1016_j_molonc_2014_01_004 crossref_primary_10_1007_s11259_006_3335_z crossref_primary_10_1158_1535_7163_1183_3_10 |
| ContentType | Journal Article |
| DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 5PM |
| DOI | 10.1172/JCI3785 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EndPage | 1392 |
| ExternalDocumentID | 10_1172_JCI3785 9769331 |
| Genre | Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S Journal Article |
| GrantInformation_xml | – fundername: NCI NIH HHS grantid: CA01760 – fundername: NCI NIH HHS grantid: CA72526 – fundername: NCI NIH HHS grantid: CA 72261 |
| GroupedDBID | --- -~X .55 .GJ .XZ 08P 29K 2WC 354 3O- 53G 5GY 5RE 5RS 8F7 AAWTL AAYOK ABOCM ABPMR ACGFO ACIHN ACNCT ACPRK ADBBV AEAQA AENEX AFCHL AFFNX AHMBA AI. ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS ASPBG AVWKF AZFZN BAWUL CGR CS3 CUY CVF D-I DIK DU5 E3Z EBS ECM EIF EJD EMB F5P FRP GROUPED_DOAJ GX1 HYE H~9 IAO IEA IHR INH INR IOF IPO J5H KQ8 L7B M1P M5~ MVM N4W NPM OBH OCB ODZKP OFXIZ OGEVE OHH OK1 OVD OVIDX P2P P6G RPM TEORI TR2 TVE UHU VH1 VVN W2D WH7 WOQ WOW X7M XSB YFH YHG YKV YOC ZGI ZXP ZY1 ~H1 AAYXX CITATION 7X8 5PM |
| ID | FETCH-LOGICAL-c401t-535e14fb3b111dbb61568244271c453ec564c9b7398177c6526b0e7877ac7d1c3 |
| IEDL.DBID | RPM |
| ISSN | 0021-9738 |
| IngestDate | Tue Sep 17 21:17:47 EDT 2024 Fri Oct 25 04:20:54 EDT 2024 Thu Sep 26 18:43:38 EDT 2024 Sat Sep 28 07:40:12 EDT 2024 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 7 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c401t-535e14fb3b111dbb61568244271c453ec564c9b7398177c6526b0e7877ac7d1c3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | http://www.jci.org/articles/view/3785/files/pdf |
| PMID | 9769331 |
| PQID | 69955100 |
| PQPubID | 23479 |
| PageCount | 8 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_508986 proquest_miscellaneous_69955100 crossref_primary_10_1172_JCI3785 pubmed_primary_9769331 |
| PublicationCentury | 1900 |
| PublicationDate | 1998-Oct-01 1998-10-1 19981001 |
| PublicationDateYYYYMMDD | 1998-10-01 |
| PublicationDate_xml | – month: 10 year: 1998 text: 1998-Oct-01 day: 01 |
| PublicationDecade | 1990 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | The Journal of clinical investigation |
| PublicationTitleAlternate | J Clin Invest |
| PublicationYear | 1998 |
| References | 2158859 - Cell. 1990 Apr 20;61(2):203-12 7621070 - Immunity. 1995 Jul;3(1):1-4 8939983 - J Biol Chem. 1996 Nov 22;271(47):30290-6 8977232 - Blood. 1996 Dec 15;88(12):4415-25 8339264 - Cancer Res. 1993 Aug 1;53(15):3579-84 1502203 - Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7836-9 1524803 - Eur Arch Otorhinolaryngol. 1992;249(5):243-7 8574972 - Nat Med. 1996 Feb;2(2):237-40 2334906 - Cancer Res. 1990 May 15;50(10):3113-8 1742894 - Clin Otolaryngol Allied Sci. 1991 Oct;16(5):466-9 8397445 - Science. 1993 Sep 24;261(5129):1739-44 8826952 - Cancer. 1996 Sep 15;78(6):1284-92 9041204 - Cancer Res. 1997 Mar 1;57(5):978-87 1501243 - J Membr Biol. 1992 Jun;128(2):81-9 7640654 - Cell Biol Int. 1995 May;19(5):373-88 8667988 - Laryngoscope. 1996 Jul;106(7):884-8 9625170 - J Natl Cancer Inst. 1998 Jun 3;90(11):824-32 7538664 - Proc Natl Acad Sci U S A. 1995 May 9;92(10):4215-8 8702638 - J Biol Chem. 1996 Aug 9;271(32):19483-8 8839834 - Blood. 1996 Oct 1;88(7):2442-9 1904421 - Jpn J Cancer Res. 1991 Apr;82(4):403-10 7716810 - Trends Genet. 1995 Feb;11(2):69-74 8657134 - Mol Cell Biol. 1996 Apr;16(4):1595-603 9242377 - Oncogene. 1997 Jul 24;15(4):409-16 8289831 - Mol Cell Biol. 1994 Feb;14(2):914-22 1459725 - Int J Cancer. 1992 Dec 2;52(6):862-6 7710952 - Br J Cancer. 1995 Apr;71(4):840-4 7541555 - Science. 1995 Jul 7;269(5220):81-3 8140422 - Science. 1994 Apr 1;264(5155):95-8 1733967 - J Biol Chem. 1992 Feb 5;267(4):2714-22 7515879 - J Biol Chem. 1994 Jun 10;269(23):16297-304 9002549 - FASEB J. 1996 Dec;10(14):1578-88 8541528 - Blood. 1995 Dec 15;86(12):4409-16 8887543 - EMBO J. 1996 Sep 2;15(17):4515-25 7490523 - J Endocrinol. 1995 Oct;147(1):11-23 8787685 - J Clin Invest. 1996 Sep 1;98(5):1218-30 9566874 - Mol Cell Biol. 1998 May;18(5):2545-52 2766286 - Cancer Res. 1989 Sep 15;49(18):5167-75 2752531 - Carcinogenesis. 1989 Aug;10(8):1553-6 2176154 - EMBO J. 1990 Dec;9(13):4477-84 8670868 - EMBO J. 1996 Jul 15;15(14):3651-8 9419415 - Cell Growth Differ. 1997 Dec;8(12):1267-76 8066447 - Science. 1994 Aug 19;265(5175):1093-5 8942998 - Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13704-8 |
| References_xml | |
| SSID | ssj0014454 |
| Score | 2.2130554 |
| Snippet | Stimulation of epidermal growth factor receptor (EGFR) by ligand(s) leads to activation of signaling molecules including Stat1 and Stat3, two members of the... |
| SourceID | pubmedcentral proquest crossref pubmed |
| SourceType | Open Access Repository Aggregation Database Index Database |
| StartPage | 1385 |
| SubjectTerms | Carcinoma, Hepatocellular Carcinoma, Squamous Cell Cell Division - drug effects Cells, Cultured DNA-Binding Proteins - metabolism Epithelial Cells - cytology Epithelial Cells - drug effects Epithelial Cells - physiology Head and Neck Neoplasms Humans Kinetics Liver Neoplasms Mouth Mucosa - cytology Mouth Mucosa - drug effects Mouth Mucosa - physiology Receptor, Epidermal Growth Factor - drug effects Receptor, Epidermal Growth Factor - physiology Recombinant Proteins - pharmacology STAT1 Transcription Factor STAT3 Transcription Factor Trans-Activators - metabolism Transforming Growth Factor alpha - pharmacology Transforming Growth Factor alpha - physiology Tumor Cells, Cultured |
| Title | Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/9769331 https://search.proquest.com/docview/69955100 https://pubmed.ncbi.nlm.nih.gov/PMC508986 |
| Volume | 102 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT9wwELYKUhEXVNqiLi3gQ69m4_UrPlarIkBaVKEicYtsxy4rgbNAlt_P2PEitty4JbITxePJzDfjeSD0s675xFrBialMIFwzQ4wxgojAQV_aVtqQ8p1nF_L0ip9fi-uSFPZYwiqjs_PjeHt3HOc3ObZycefGqzix8Z_ZFECFruV4A20Af64s9HJywLkolZcp0YrVQ6IsBT09Pp-eMVWLbfRRpw6AjK7rojcA8_84yVeK5-QT2imIEf8avmwXffDxM9qalTPxL-j-0qdo3uzmw13ACT4ybJc9jl2f7yhO2QuD7xUDSMU-tYUFiXyL_4EV3t_goesOBunnF3BBcE4oATCKk2N_Ness4qd5_9B9RVcnv_9OT0lppEAcmE89EUx4yoNlFiRbay2gGFmDXp8o6rhg3gnJnbaK6Zoq5aSYSFt5-JWVcaqlju2hzdhF_w1hFwQYgLQVwVW8DdoEQdsqUC08a4ErRzClkLRZDPUymmxnqElT6D9CRytSN8DLaR0m-m752EitAcBV1QjtDYR_eUXZsBGSazvyMp6KZK-PAO_kYtkDr-y_98HvaDtnIebwvR9os39Y-gOAIb09zHz3DAdH4Ao |
| link.rule.ids | 230,315,730,783,787,888,27936,27937,53804,53806 |
| linkProvider | National Library of Medicine |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELagCOgF8apYoK0PXN2N16_4iFZUu223QqiVeotsx6Yrtc7SZvn9jB1vxcKtt0R2omQ8nvlmPA-EvtQ1n1grODGVCYRrZogxRhAROOhL20obUr7z4lzOLvnJlbgqSWH3JawyOrs8ije3R3F5nWMrV7duvIkTG39fTAFU6FqOn6JnsF0rvrHRy9kB56LUXqZEK1YPqbIUNPX4ZDpnqha76LlOPQAZ3dZG_0HMfyMl_1I9x6_Rq4IZ8dfh296gJz6-RS8W5VT8Hfr1w6d43uzow13ACUAybNc9jl2f7yhO-QuD9xUDTMU-NYYFmXyDf4Id3l_joe8OBvnnV3BBcE4pATiKk2t_M2se8e9lf9e9R5fH3y6mM1JaKRAHBlRPBBOe8mCZBdnWWgs4Rtag2SeKOi6Yd0Jyp61iuqZKOSkm0lYeNrMyTrXUsT20E7voPyDsggATkLYiuIq3QZsgaFsFqoVnLfDlCKYUkjaroWJGky0NNWkK_UfocEPqBrg5_YeJvlvfN1JrgHBVNUJ7A-EfXlEWbITk1oo8jKcy2dsjwD25XPbALR8f--Ahejm7WJw1Z_Pz009oN-ck5mC-z2inv1v7fQAlvT3IPPgH-d7jYA |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB6VIqpeEK-KBdr6wDVNvH7FR7Sw6rZsVSEq9RbZjk1XapOlZPn9jJ2kYsuNWyI7UTIez3wzngfAx7LkU2sFz0xhQsY1M5kxRmQicNSXtpY2xHzn5YU8veJn1-J6B8oxFyYF7Tu7Omlu706a1U2KrVzfuXyME8svlzMEFbqU-boO-RN4ilu2kKOdPpwfcC6G-ss004qVfbosRW2dn80WTJViH57p2AeQ0W2N9A_MfBwt-Zf6mb-A5wNuJJ_673sJO755BXvL4WT8Nfz85mNMb3L2kTaQCCIZsZuONG2X7iiJOQy9B5YgVCU-NodFuXxLfqAt3t2QvvcOQRno13iRkZRWgpCURPf-OGvRkN-r7r59A1fzL99np9nQTiFzaER1mWDCUx4ssyjfamsRy8gStftUUccF805I7rRVTJdUKSfFVNrC44ZWxqmaOnYAu03b-LdAXBBoBtJaBFfwOmgTBK2LQLXwrEbenOCUgaTVuq-aUSVrQ02rgf4TOB5JXSFHx_8wjW83vyqpNcK4opjAQU_4h1cMCzYBubUiD-OxVPb2CHJQKpndc8y7_33wGPYuP8-rr4uL8_ewn9ISUzzfB9jt7jf-EHFJZ48SC_4BP__kcw |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Requirement+of+Stat3+but+not+Stat1+activation+for+epidermal+growth+factor+receptor-+mediated+cell+growth+In+vitro&rft.jtitle=The+Journal+of+clinical+investigation&rft.au=Grandis%2C+J+R&rft.au=Drenning%2C+S+D&rft.au=Chakraborty%2C+A&rft.au=Zhou%2C+M+Y&rft.date=1998-10-01&rft.issn=0021-9738&rft.volume=102&rft.issue=7&rft.spage=1385&rft.epage=1392&rft_id=info:doi/10.1172%2FJCI3785&rft.externalDBID=n%2Fa&rft.externalDocID=10_1172_JCI3785 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0021-9738&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0021-9738&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0021-9738&client=summon |