Time dependency in the regenerative response to injury of the rat corneal epithelium

In the present study a central corneal epithelial defect (diameter 3.5 mm) was made in both eyes at 12:00 h in one group of rats and at 24:00 h in another group to see if the regenerative proliferation is influenced by circadian rhythms. The labeling index and the mitotic rate were registered at 4-h...

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Bibliographic Details
Published inChronobiology international Vol. 11; no. 3; p. 173
Main Authors Sandvig, K U, Haaskjold, E, Refsum, S B
Format Journal Article
LanguageEnglish
Published England 1994
Subjects
Animals
Circadian Rhythm
Conjunctiva - physiology
Conjunctiva - physiopathology
Cornea - physiology
Cornea - physiopathology
Corneal Injuries
Darkness
Epithelium - physiology
Female
Light
Rats
Rats, Wistar
Regeneration - physiology
Wound Healing - physiology
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Summary:In the present study a central corneal epithelial defect (diameter 3.5 mm) was made in both eyes at 12:00 h in one group of rats and at 24:00 h in another group to see if the regenerative proliferation is influenced by circadian rhythms. The labeling index and the mitotic rate were registered at 4-h intervals in the perilimbal conjunctiva, the limbal area, and different parts of the cornea from the following morning until noon the day after that. The most pronounced regenerative proliferation was seen in the midperipheral and peripheral cornea. The regenerative response occurred in both groups 24-28 h after the injury, but was highly influenced by the normal circadian rhythms, especially with regard to the mitotic rate. The results support the theory that even regeneration is influenced by a circadian proliferative factor.
ISSN:0742-0528
1525-6073
DOI:10.3109/07420529409057237