Characteristics and consequences of airway colonization by filamentous fungi in 201 adult patients with cystic fibrosis in France

• Published in: Medical mycology (Oxford) Vol. 48 Suppl 1; p. S32
• Main Authors: Paugam, André, Baixench, Marie-Thérèse, Demazes-Dufeu, Nadine, Burgel, Pierre-Régis, Sauter, Elise, Kanaan, Reem, Dusser, Daniel, Dupouy-Camet, Jean, Hubert, Dominique
• Format: Journal Article
• Language: English
• Published: England 01.11.2010
• Subjects: Adolescent; Adult; Aged; Aspergillosis, Allergic Bronchopulmonary - epidemiology; Aspergillosis, Allergic Bronchopulmonary - microbiology; Aspergillus fumigatus - classification; Aspergillus fumigatus - isolation & purification; Cystic Fibrosis - complications; Cystic Fibrosis - epidemiology; Cystic Fibrosis - microbiology; Female; France - epidemiology; Fungi - isolation & purification; Humans; Lung Diseases, Fungal - epidemiology; Lung Diseases, Fungal - microbiology; Lung Diseases, Fungal - physiopathology; Male; Middle Aged; Multivariate Analysis; Scedosporium - classification; Scedosporium - isolation & purification; Sputum - microbiology; Young Adult; France
• ISSN: 1460-2709
• DOI: 10.3109/13693786.2010.503665

A total of 657 sputum samples from 201 cystic fibrosis adult patients were collected during a 24-month period (2005-2006). We retrospectively analyzed the fungal colonization of the respiratory tract of these individuals by linking medical records and microbiological data. Filamentous fungi were isolated from specimens of 65.6% of the patients, with Aspergillus fumigatus being the predominant species recovered as it was found in specimens of 56.7% of the patients. We observed no difference for gender, pancreatic status and cirrhosis in patients with or without A. fumigatus colonization. We found a higher percentage of recovery of Pseudomonas aeruginosa, Stenotrophomonas maltophilia and nontuberculous mycobacteria in patients with A. fumigatus colonization. During the follow-up period of the study, 8.9% of the patients were diagnosed with allergic bronchopulmonary aspergillosis (ABPA). By a multivariate analysis we demonstrated that Scedosporium apiospermum was significantly associated with ABPA (Odds ratio = 13 [2-80]) as opposed to A. fumigatus (Odds ratio = 1.58 [0.49-5.05]).