Sex differences in cocaine-induced behavioral responses, pharmacokinetics, and monoamine levels

• Published in: Neuropharmacology Vol. 46; no. 5; pp. 672 - 687
• Main Authors: Festa, Eugene D., Russo, Scott J., Gazi, Farhad M., Niyomchai, Tipyamol, Kemen, Lynne M., Lin, Shen-Nan, Foltz, Rodger, Jenab, Shirzad, Quinones-Jenab, Vanya
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.04.2004
• Subjects: Animals; Biogenic Monoamines - blood; Biogenic Monoamines - metabolism; Brain - drug effects; Brain - metabolism; Cocaine; Cocaine - blood; Cocaine - pharmacokinetics; Cocaine - pharmacology; Dopamine; Dose-Response Relationship, Drug; Female; Gender; Male; Metabolism; Motor Activity - drug effects; Motor Activity - physiology; Rats; Rats, Inbred F344; Serotonin; Sex; Sex Characteristics; Cocaine; Dopamine; Gender; Serotonin; Metabolism; Sex

Female rats display a more robust behavioral response to acute cocaine administration than do male rats. However, a clear understanding of the biological mechanisms underlying these differences remains elusive. The present study investigated whether sexual dimorphisms in cocaine-induced motor behavi...