Thrombin Decrease in Thrombin Generation after Heparin Administration in a Homozygous Type II Heparin-Binding Site Antithrombin-Deficient Pregnant Woman

• Published in: Medical principles and practice Vol. 32; no. 4-5; pp. 308 - 312
• Main Authors: Malikova, Ivana, Husakova, Martina, Bilkova, Jana, Brzezkova, Radka, Kvasnicka, Tomas
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.11.2023
• Subjects: Anticoagulants; Binding sites; Brief Report; Congenital diseases; Plasma; Pregnancy; Women; Austria; Germany; Antithrombin deficiency; Thrombin generation; Heparin
• ISSN: 1011-7571; 1423-0151; 1423-0151
• DOI: 10.1159/000533801

Objectives: There is a major problem in providing prophylactic treatment in antithrombin (AT)-deficient pregnant women with a homozygous mutation of the heparin-binding site and AT level of 17%. The aim of the study was to determine the effectiveness of heparin by monitoring changes in thrombin gene...