Effects of Ethnicity and Sex on the Pharmacokinetics and Pharmacodynamics of the Selective Sphingosine-1-Phosphate Receptor 1 Modulator Ponesimod: A Clinical Study in Japanese and Caucasian Subjects

• Published in: Pharmacology Vol. 94; no. 5-6; pp. 223 - 229
• Main Authors: Reyes, Maribel, Hoch, Matthias, Brossard, Patrick, Dingemanse, Jasper
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.01.2014
• Subjects: Adult; Asian Continental Ancestry Group; Autoimmune diseases; Cell receptors; Drug metabolism; Drug therapy; Ethnicity; European Continental Ancestry Group; Female; Gender; Health aspects; Humans; Lymphocyte Count; Male; Observations; Original Paper; Pharmacology; Pharmacology, Experimental; Receptors, Lysosphingolipid - antagonists & inhibitors; Sphingosine; Thiazoles - adverse effects; Thiazoles - blood; Thiazoles - pharmacokinetics; Thiazoles - pharmacology; Switzerland; Ponesimod; Ethnicity; Sphingosine-1-phosphate receptor 1

The aim of this study was to evaluate the relative pharmacokinetic (PK) and pharmacodynamic (PD) properties of a single dose of ponesimod, an oral and selective sphingosine-1-phosphate receptor 1 (S1P 1 ) modulator, in Japanese and Caucasian healthy subjects and explore the effects of sex on PK. Sub...