Perisaccadic Gamma Modulation in Parkinson Disease Patients and Healthy Subjects

• Published in: Clinical EEG and neuroscience Vol. 41; no. 2; pp. 94 - 101
• Main Authors: Javaid, M.A., Weeden, J., Flom, P., Avitable, M., Glazman, S., Bodis-Wollner, I.
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.04.2010; SAGE PUBLICATIONS, INC
• Subjects: Aged; Brain; Brain - physiopathology; Brain Mapping - methods; Dopamine; Electroencephalography; Female; Humans; Male; Middle Aged; Parkinson Disease - physiopathology; Saccades; Studies; Young Adult; Parkinson Disease; Parietal Eye Field; Corollary Discharge; Frontal Eye Field; Perisaccadic EEG; Gamma Range EEG; Continuous Wavelet Transform; Voluntary Saccades
• ISSN: 1550-0594; 2169-5202
• DOI: 10.1177/155005941004100209

We quantified the anterior-posterior distribution of the gamma modulation index (GMI), an index of perisaccadic phasic modulation of the gamma (35–45 Hz) range electroencephalogram (EEG), in healthy human subjects and Parkinson disease (PD) patients. The EEG was recorded over the frontal, parietal, temporal and occipital sites in 11 idiopathic PD patients (age 50–70 years, four females), 4 age matched healthy volunteers (1 female) and 17 young healthy controls (age 21–30 years, four females) Eye movements were recorded with EOG and ISCAN camera. Subjects executed saccades to a mark at right and back to fixation point and vice versa. The saccades directed away from center/fixation (centrifugal CF) were analyzed. Two minutes of EEG were obtained from each subject for the two possible saccade types (centrifugal rightwards and leftwards at 15 degrees). Each perisaccadic EEG segment was analyzed using continuous wavelet transform for quantifying the power and time course of gamma EEG ranges for each saccade type. A three way ANOVA was used for statistical analysis. Perisaccadic GMI (peak intrasaccadic power divided by mean power) in healthy subjects was higher over the contralateral hemisphere to the saccade direction, for both centrifugal saccades at anterior, posterior and occipital recording sites. Contrary to the healthy subject GMI remained near one in PD, i.e., there was no evidence of intrasaccadic gamma power increase in PD patients.