An immune-competent, replication-permissive Syrian Hamster glioma model for evaluating Delta-24-RGD oncolytic adenovirus

• Published in: Neuro-oncology (Charlottesville, Va.) Vol. 23; no. 11; pp. 1911 - 1921
• Main Authors: Phillips, Lynette M, Li, Shoudong, Gumin, Joy, Daou, Marc, Ledbetter, Daniel, Yang, Jing, Singh, Sanjay, Parker Kerrigan, Brittany C, Hossain, Anwar, Yuan, Ying, Gomez-Manzano, Candelaria, Fueyo, Juan, Lang, Frederick F
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 02.11.2021
• Subjects: Basic and Translational Investigations; immune-competent model; glioma; oncolytic adenovirus

Abstract Background Oncolytic adenoviruses are promising new treatments against solid tumors, particularly for glioblastoma (GBM), and preclinical models are required to evaluate the mechanisms of efficacy. However, due to the species selectivity of adenovirus, there is currently no single animal mo...