Dietary Ribonucleic Acid Suppresses Inflammation of Adipose Tissue and Improves Glucose Intolerance That Is Mediated by Immune Cells in C57BL/6 Mice Fed a High-Fat Diet

• Published in: Journal of Nutritional Science and Vitaminology Vol. 61; no. 1; pp. 73 - 78
• Main Authors: SAKAI, Tohru, TAKI, Tomoyo, NAKAMOTO, Akiko, TAZAKI, Shiho, ARAKAWA, Mai, NAKAMOTO, Mariko, TSUTSUMI, Rie, SHUTO, Emi
• Format: Journal Article
• Language: English
• Published: Japan Center for Academic Publications Japan 2015
• Subjects: Adipose Tissue - drug effects; Adipose Tissue - metabolism; Adipose Tissue - pathology; Animals; Area Under Curve; B-Lymphocytes - metabolism; Blood Glucose - metabolism; Cytokines - blood; Cytokines - genetics; Cytokines - metabolism; Diet, High-Fat; Dietary Supplements; Glucose Intolerance - diet therapy; Glucose Intolerance - drug therapy; Glucose Intolerance - etiology; Glucose Intolerance - metabolism; Homeodomain Proteins - genetics; inflammation; Inflammation - diet therapy; Inflammation - etiology; Interleukin-6 - blood; Lymphocytes - metabolism; Macrophages - metabolism; Male; Mice, Inbred C57BL; Mice, Knockout; obesity; Obesity - etiology; Obesity - metabolism; Obesity - pathology; RAG-1 knockout mice; ribonucleic acid; RNA - pharmacology; RNA - therapeutic use; RNA, Messenger - metabolism; T and B cell; T-Lymphocytes - metabolism

Recent evidence suggests that immune cells play an important role in differentiation of inflammatory macrophages in adipose tissue, which contributes to systemic chronic inflammation. Dietary ribonucleic acid (RNA) has been shown to modulate immune function. We hypothesized that RNA affects immune c...