Inhibition of ESCRT-independent extracellular vesicles biogenesis suppresses enterovirus 71 replication and pathogenesis in mice

• Published in: International journal of biological macromolecules Vol. 267; no. Pt 1; p. 131453
• Main Authors: Liang, Yicong, Kong, Yue, Rao, Menglan, Zhou, Xing, Li, Chengcheng, Meng, Yi, Chen, Yanxi, Li, Hongjian, Luo, Zhen
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2024
• Subjects: biogenesis; blood serum; body weight changes; Enterovirus 71; Enterovirus A; epithelium; Extracellular vesicles; hand, foot and mouth disease; humans; intestines; pathogenesis; progeny; therapeutics; viral load; Viral replication and pathogenesis; virus replication; Extracellular vesicles; Enterovirus 71; Viral replication and pathogenesis

Enterovirus 71 (EV71) causes hand-foot-and-mouth disease (HFMD), neurological complications, and even fatalities in infants. Clinically, the increase of extracellular vesicles (EVs) in EV71 patients' serum was highly associated with the severity of HFMD. EV71 boosts EVs biogenesis in an endosom...