Insights into the interaction of human serum albumin with ionic liquids – Thermodynamic, spectroscopic and molecular modelling studies

• Published in: International journal of biological macromolecules Vol. 249; p. 125883
• Main Authors: Kowalska, Dorota, Dołżonek, Joanna, Żamojć, Krzysztof, Samsonov, Sergey A., Maszota-Zieleniak, Martyna, Makowska, Joanna, Stepnowski, Piotr, Białk-Bielińska, Anna, Wyrzykowski, Dariusz
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 30.09.2023
• Subjects: bioaccumulation; calorimetry; fluorescence emission spectroscopy; human serum albumin; ligands; Molecular dynamics simulations; Protein binding; sorption; Thermal stability; titration; Thermal stability; Molecular dynamics simulations; Protein binding

Human serum albumin (HSA) effectively binds different types of low-molecular-weight compounds and thus enables their distribution in living organisms. Recently, it has been reported that the protein-ligand interactions play a crucial role in bioaccumulation processes and provide an important sorptio...