TRIM79α, an interferon-stimulated gene product, restricts tick-borne encephalitis virus replication by degrading the viral RNA polymerase

• Published in: Cell host & microbe Vol. 10; no. 3; pp. 185 - 196
• Main Authors: Taylor, R Travis, Lubick, Kirk J, Robertson, Shelly J, Broughton, James P, Bloom, Marshall E, Bresnahan, Wade A, Best, Sonja M
• Format: Journal Article
• Language: English
• Published: United States 15.09.2011
• Subjects: Animals; Carrier Proteins - genetics; Carrier Proteins - metabolism; Cell Line; DNA-Directed RNA Polymerases - genetics; DNA-Directed RNA Polymerases - metabolism; Encephalitis Viruses, Tick-Borne - enzymology; Encephalitis Viruses, Tick-Borne - genetics; Encephalitis Viruses, Tick-Borne - physiology; Encephalitis, Tick-Borne - genetics; Encephalitis, Tick-Borne - metabolism; Encephalitis, Tick-Borne - virology; Humans; Mice; Mice, Inbred C57BL; Protein Binding; Viral Proteins - genetics; Viral Proteins - metabolism; Virus Replication

In response to virus infection, type I interferons (IFNs) induce several genes, most of whose functions are largely unknown. Here, we show that the tripartite motif (TRIM) protein, TRIM79α, is an IFN-stimulated gene (ISG) product that specifically targets tick-borne encephalitis virus (TBEV), a Flav...