Intrinsic disorder in proteins: Relevance to protein assemblies, drug design and host-pathogen interactions

• Published in: Progress in biophysics and molecular biology Vol. 156; pp. 34 - 42
• Main Authors: Blundell, Tom L., Gupta, Munishwar N., Hasnain, Seyed E.
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.10.2020
• Subjects: Artemis; Intrinsic disordered proteins; Mycobacterium tuberculosis; PE/PPE; Protein promiscuity; Protein structure; Rad51-BRCA2; Regulatory proteins; Short linear motifs; Mycobacterium tuberculosis; Protein promiscuity; Short linear motifs; Intrinsic disordered proteins; Artemis; Rad51-BRCA2; PE/PPE; Protein structure; Regulatory proteins

Intrinsic disorder in proteins resulting in considerable variation in structure can lead to multiple functions including multi-specificity and diverse pathologies. Protein interfaces can involve disordered regions that assemble through a concerted-fold-and-bind mechanism. The binding involves both e...