Patient-derived organoids can predict response to chemotherapy in metastatic colorectal cancer patients

• Published in: Science translational medicine Vol. 11; no. 513
• Main Authors: Ooft, Salo N, Weeber, Fleur, Dijkstra, Krijn K, McLean, Chelsea M, Kaing, Sovann, van Werkhoven, Erik, Schipper, Luuk, Hoes, Louisa, Vis, Daniel J, van de Haar, Joris, Prevoo, Warner, Snaebjornsson, Petur, van der Velden, Daphne, Klein, Michelle, Chalabi, Myriam, Boot, Henk, van Leerdam, Monique, Bloemendal, Haiko J, Beerepoot, Laurens V, Wessels, Lodewyk, Cuppen, Edwin, Clevers, Hans, Voest, Emile E
• Format: Journal Article
• Language: English
• Published: United States 09.10.2019

There is a clear and unmet clinical need for biomarkers to predict responsiveness to chemotherapy for cancer. We developed an in vitro test based on patient-derived tumor organoids (PDOs) from metastatic lesions to identify nonresponders to standard-of-care chemotherapy in colorectal cancer (CRC). I...