Protective effects of an anti-4-HNE monoclonal antibody against liver injury and lethality of endotoxemia in mice

• Published in: European journal of pharmacology Vol. 950; p. 175702
• Main Authors: Qiao, Handong, Morioka, Yuta, Wang, Dengli, Liu, Keyue, Gao, Shangze, Wake, Hidenori, Ousaka, Daiki, Teshigawara, Kiyoshi, Mori, Shuji, Nishibori, Masahiro
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 05.07.2023
• Subjects: 4-HNE; Acute liver failure; Animals; anti-4-HNE mAb; Antibodies, Monoclonal - pharmacology; Antibodies, Monoclonal - therapeutic use; Endotoxemia; Endotoxemia - chemically induced; HMGB1 Protein - metabolism; Interleukin-6 - metabolism; Lipopolysaccharides - pharmacology; Liver; LPS; Mice; Sepsis; Tumor Necrosis Factor-alpha - metabolism; Acute liver failure; Sepsis; 4-HNE; anti-4-HNE mAb; LPS; Endotoxemia

4-hydroxy-2-nonenal (4-HNE) is a lipid peroxidation product that is known to be elevated during oxidative stress. During systemic inflammation and endotoxemia, plasma levels of 4-HNE are elevated in response to lipopolysaccharide (LPS) stimulation. 4-HNE is a highly reactive molecule due to its gene...