Measuring energy expenditure in narcolepsy using doubly labeled water and respiration chamber calorimetry

• Published in: Sleep (New York, N.Y.) Vol. 48; no. 4
• Main Authors: Donjacour, Claire E H M, Gool, Jari K, Schoffelen, Paul F, Wouters, Loek, Overeem, Sebastiaan, Lammers, Gert Jan, Pijl, Hanno, Westerterp, Klaas R
• Format: Journal Article
• Language: English
• Published: United States 01.04.2025
• Subjects: Accelerometry; Adult; Basal Metabolism - physiology; Calorimetry - methods; Calorimetry, Indirect; Energy Metabolism - physiology; Humans; Male; Motor Activity - physiology; Narcolepsy - metabolism; Narcolepsy - physiopathology; hypocretin; metabolism; orexin; overweight; accelerometer

Hypocretin deficiency causes type 1 narcolepsy, a condition characterized by excessive daytime sleepiness, cataplexy, and fragmented nocturnal sleep. Two-thirds of people with narcolepsy are also overweight, of which half are obese. The pathophysiology behind weight gain in people with narcolepsy re...