Comparative pharmacokinetics of the main active components in normal and ulcerative colitis rats after oral administration of Zingiberis Rhizoma–Ginseng Radix et Rhizoma herb pair and its single herb extracts by LC–MS/MS

• Published in: Journal of separation science Vol. 45; no. 13; pp. 2228 - 2238
• Main Authors: Wan, Yue, Dong, Zhiling, Li, Huifang, Yang, Lei, Li, Wenwen, Zhu, Ke, Jiang, Shu, Qian, Dawei, Duan, Jinao
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.07.2022
• Subjects: Administration, Oral; Animals; chemical species; Chromatography, High Pressure Liquid - methods; Chromatography, Liquid; Colitis, Ulcerative - drug therapy; Correlation coefficients; Drugs, Chinese Herbal - analysis; Gingerol; ginsenosides; herb pair; Herbs; Inflammatory bowel disease; Liquid chromatography; Mass spectrometry; Oral administration; Panax; Panax - chemistry; Pharmacokinetics; Pharmacology; Plant Extracts; Rats; rhizomes; separation; synergism; Synergistic effect; tandem mass spectrometry; Tandem Mass Spectrometry - methods; ulcerative colitis; Zingiber officinale; pharmacokinetics; herb pair; liquid chromatography; ulcerative colitis

Zingiberis Rhizoma and Ginseng Radix et Rhizoma are usually used together for the treatment of ulcerative colitis in clinical practices. However, their compatibility mechanism remains unclear. In this study, a rapid and sensitive liquid chromatography with tandem mass spectrometry method was develop...