Hyperbaric Oxygen Preconditioning Attenuates Hemorrhagic Transformation Through Reactive Oxygen Species/Thioredoxin-Interacting Protein/Nod-Like Receptor Protein 3 Pathway in Hyperglycemic Middle Cerebral Artery Occlusion Rats

• Published in: Critical care medicine Vol. 44; no. 6; p. e403
• Main Authors: Guo, Zhen-Ni, Xu, Liang, Hu, Qin, Matei, Nathanael, Yang, Peng, Tong, Lu-Sha, He, Yue, Guo, Zongduo, Tang, Jiping, Yang, Yi, Zhang, John H
• Format: Journal Article
• Language: English
• Published: United States 01.06.2016
• Subjects: Acetylcysteine - metabolism; Animals; Arterial Occlusive Diseases - complications; Arterial Occlusive Diseases - metabolism; Brain Infarction - etiology; Brain Infarction - metabolism; Brain Infarction - prevention & control; Carrier Proteins - genetics; Carrier Proteins - metabolism; Cerebral Hemorrhage - etiology; Cerebral Hemorrhage - metabolism; Cerebral Hemorrhage - prevention & control; Glucose; Hyperbaric Oxygenation; Hyperglycemia - chemically induced; Inflammasomes - metabolism; Male; Matrix Metalloproteinase 9 - metabolism; Middle Cerebral Artery; Prospective Studies; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species - metabolism; Receptors, Cell Surface; RNA, Small Interfering; Signal Transduction - genetics

To clarify whether hyperbaric oxygen preconditioning can attenuate hyperglycemia-enhanced hemorrhagic transformation and to establish a role for Nod-like receptor protein 3 inflammasome in the pathophysiology of hemorrhagic transformation. Controlled prospective animal study. University research lab...