Midazolam Dose Optimization in Critically Ill Pediatric Patients With Acute Respiratory Failure: A Population Pharmacokinetic-Pharmacogenomic Study

• Published in: Critical care medicine Vol. 47; no. 4; p. e301
• Main Authors: Zuppa, Athena F, Conrado, Daniela J, Zane, Nicole R, Curley, Martha A Q, Bradfield, Jonathan, Hakonarson, Hakon, Gastonguay, Madeleine S, Moorthy, Ganesh, Prodell, Janice, Gastonguay, Marc R
• Format: Journal Article
• Language: English
• Published: United States 01.04.2019
• Subjects: Child; Critical Illness - therapy; Dose-Response Relationship, Drug; Humans; Hypnotics and Sedatives - administration & dosage; Hypnotics and Sedatives - pharmacokinetics; Male; Midazolam - administration & dosage; Midazolam - pharmacokinetics; Pharmacogenomic Testing; Prospective Studies; Respiration, Artificial; Respiratory Distress Syndrome, Adult - drug therapy; Respiratory Distress Syndrome, Adult - physiopathology
• ISSN: 1530-0293
• DOI: 10.1097/CCM.0000000000003638

To develop a pharmacokinetic-pharmacogenomic population model of midazolam in critically ill children with primary respiratory failure. Prospective pharmacokinetic-pharmacogenomic observational study. Thirteen PICUs across the United States. Pediatric subjects mechanically ventilated for acute respi...