L-arginine protects cementoblasts against hypoxia-induced apoptosis through Sirt1-enhanced autophagy

• Published in: Journal of periodontology (1970) Vol. 93; no. 12; p. 1961
• Main Authors: Xu, Lei, Tan, Xi, Bai, Siyu, Wu, Hongyan, Luo, Hong, Ye, Yusi, Fang, Lingli, Dai, Hongwei, Huang, Lan
• Format: Journal Article
• Language: English
• Published: United States 01.12.2022
• Subjects: Animals; Apoptosis; Arginine - pharmacology; Arginine - therapeutic use; Autophagy; Dental Cementum - metabolism; Hypoxia; Mice; Rats; Resveratrol - pharmacology; Resveratrol - therapeutic use; Root Resorption; Sirtuin 1 - metabolism; Sirtuin 1 - pharmacology; apoptosis; orthodontics; cementum; gene regulation

L-arginine (L-arg) can reduce apoptosis in a variety of cells. Cementoblast apoptosis is related to root resorption during orthodontic treatment. In the present study, we aimed to study the regulatory effect and potential mechanism of L-arg on cementoblast apoptosis and root resorption. The apoptosi...