Detection of chromosomal aberrations in seminomatous germ cell tumours using comparative genomic hybridization
Comparative genomic hybridization (CGH) was used to evaluate tissue specimens from 16 seminomas in order to elucidate the pathogenesis of germ cell tumours in males. A characteristic pattern of losses and gains within the entire genomes was detected in 94% of the seminomas by comparing the ratio pro...
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Published in | Genes chromosomes & cancer Vol. 20; no. 4; pp. 412 - 418 |
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Main Authors | , , , , , , , , , |
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01.12.1997
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Abstract | Comparative genomic hybridization (CGH) was used to evaluate tissue specimens from 16 seminomas in order to elucidate the pathogenesis of germ cell tumours in males. A characteristic pattern of losses and gains within the entire genomes was detected in 94% of the seminomas by comparing the ratio profiles of the tumours with a standard of cytogenetically normal genomic DNA. Losses represented 43% of the total number of alterations often affecting chromosomes and chromosome arms 4, 5, 11, 13q, and 18q. Gains amounted to 57% and were often observed on 1q, 7, 8, 12, 14q, 15q, 21q, and 22q. Aberrations of 12p and 21q appeared most consistently. Results from CGH analysis displayed no relationship to the clinical stages of the malignancy. Some rare aberrations appeared, however, only in clinical stage II and in tumours showing relapse in the contralateral testis following orchiectomy, although the alterations were not present in all of the tumours in question. Losses of 16q13‐21 and gains of 9q22.1‐22.2 were demonstrated in both groups, while loss of 16p12 and gains of 6p21 and 6q23.3‐24 were detected in the latter group as well. In conclusion, a specific pattern of chromosomal alterations was demonstrated in the seminomas by improved detection criteria, which increased specificity and sensitivity. The rare aberrations, which appeared only in tumours in clinical stage II and relapsed tumours, may be linked to tumour progression, invasiveness, and bilateral disease. Genes Chromosomes Cancer 20:412–418, 1997. © 1997 Wiley‐Liss, Inc. |
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AbstractList | Comparative genomic hybridization (CGH) was used to evaluate tissue specimens from 16 seminomas in order to elucidate the pathogenesis of germ cell tumours in males. A characteristic pattern of losses and gains within the entire genomes was detected in 94% of the seminomas by comparing the ratio profiles of the tumours with a standard of cytogenetically normal genomic DNA. Losses represented 43% of the total number of alterations often affecting chromosomes and chromosome arms 4, 5, 11, 13q, and 18q. Gains amounted to 57% and were often observed on 1q, 7, 8, 12, 14q, 15q, 21q, and 22q. Aberrations of 12p and 21q appeared most consistently. Results from CGH analysis displayed no relationship to the clinical stages of the malignancy. Some rare aberrations appeared, however, only in clinical stage II and in tumours showing relapse in the contralateral testis following orchiectomy, although the alterations were not present in all of the tumours in question. Losses of 16q13‐21 and gains of 9q22.1‐22.2 were demonstrated in both groups, while loss of 16p12 and gains of 6p21 and 6q23.3‐24 were detected in the latter group as well. In conclusion, a specific pattern of chromosomal alterations was demonstrated in the seminomas by improved detection criteria, which increased specificity and sensitivity. The rare aberrations, which appeared only in tumours in clinical stage II and relapsed tumours, may be linked to tumour progression, invasiveness, and bilateral disease. Genes Chromosomes Cancer 20:412–418, 1997. © 1997 Wiley‐Liss, Inc. Comparative genomic hybridization (CGH) was used to evaluate tissue specimens from 16 seminomas in order to elucidate the pathogenesis of germ cell tumours in males. A characteristic pattern of losses and gains within the entire genomes was detected in 94% of the seminomas by comparing the ratio profiles of the tumours with a standard of cytogenetically normal genomic DNA. Losses represented 43% of the total number of alterations often affecting chromosomes and chromosome arms 4, 5, 11, 13q, and 18q. Gains amounted to 57% and were often observed on 1q, 7, 8, 12, 14q, 15q, 21q, and 22q. Aberrations of 12p and 21q appeared most consistently. Results from CGH analysis displayed no relationship to the clinical stages of the malignancy. Some rare aberrations appeared, however, only in clinical stage II and in tumours showing relapse in the contralateral testis following orchiectomy, although the alterations were not present in all of the tumours in question. Losses of 16q13-21 and gains of 9q22.1-22.2 were demonstrated in both groups, while loss of 16p12 and gains of 6p21 and 6q23.3-24 were detected in the latter group as well. In conclusion, a specific pattern of chromosomal alterations was demonstrated in the seminomas by improved detection criteria, which increased specificity and sensitivity. The rare aberrations, which appeared only in tumours in improved detection criteria, which increased specificity and sensitivity. The rare aberrations, which appeared only in tumours in clinical stage II and relapsed tumours, may be linked to tumour progression, invasiveness, and bilateral disease. |
Author | Gerdes, Tommy Ottesen, Anne Marie Rose, Hanne Philip, John Kirchhoff, Maria Petersen, Peter Meidahl Lundsteen, Claes Skakkebæk, Niels Erik De-Meyts, Ewa Rajpert Maahr, Jan |
Author_xml | – sequence: 1 givenname: Anne Marie surname: Ottesen fullname: Ottesen, Anne Marie organization: Department of Growth and Reproduction, Juliane Marie Centre, The National University Hospital, Copenhagen, Denmark – sequence: 2 givenname: Maria surname: Kirchhoff fullname: Kirchhoff, Maria organization: Chromosome Laboratory, Department of Clinical Genetics, Juliane Marie Centre, The National University Hospital, Copenhagen, Denmark – sequence: 3 givenname: Ewa Rajpert surname: De-Meyts fullname: De-Meyts, Ewa Rajpert organization: Department of Growth and Reproduction, Juliane Marie Centre, The National University Hospital, Copenhagen, Denmark – sequence: 4 givenname: Jan surname: Maahr fullname: Maahr, Jan organization: Chromosome Laboratory, Department of Clinical Genetics, Juliane Marie Centre, The National University Hospital, Copenhagen, Denmark – sequence: 5 givenname: Tommy surname: Gerdes fullname: Gerdes, Tommy organization: Chromosome Laboratory, Department of Clinical Genetics, Juliane Marie Centre, The National University Hospital, Copenhagen, Denmark – sequence: 6 givenname: Hanne surname: Rose fullname: Rose, Hanne organization: Chromosome Laboratory, Department of Clinical Genetics, Juliane Marie Centre, The National University Hospital, Copenhagen, Denmark – sequence: 7 givenname: Claes surname: Lundsteen fullname: Lundsteen, Claes organization: Chromosome Laboratory, Department of Clinical Genetics, Juliane Marie Centre, The National University Hospital, Copenhagen, Denmark – sequence: 8 givenname: Peter Meidahl surname: Petersen fullname: Petersen, Peter Meidahl organization: Department of Growth and Reproduction, Juliane Marie Centre, The National University Hospital, Copenhagen, Denmark – sequence: 9 givenname: John surname: Philip fullname: Philip, John organization: Chromosome Laboratory, Department of Clinical Genetics, Juliane Marie Centre, The National University Hospital, Copenhagen, Denmark – sequence: 10 givenname: Niels Erik surname: Skakkebæk fullname: Skakkebæk, Niels Erik organization: Department of Growth and Reproduction, Juliane Marie Centre, The National University Hospital, Copenhagen, Denmark |
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Cites_doi | 10.1016/0165-4608(96)00043-X 10.1007/BF00202476 10.1111/j.1365-2605.1987.tb00161.x 10.1159/000474564 10.1016/0165-4608(90)90115-Q 10.1002/gcc.2870110304 10.1016/S0046-8177(96)90106-9 10.1016/0165-4608(90)90011-X 10.1159/000474565 10.1016/0165-4608(83)90125-5 10.1002/gcc.2870120309 10.1002/gcc.2870100403 10.1002/gcc.2870140208 10.1002/(SICI)1098-2264(199610)17:2<78::AID-GCC2>3.0.CO;2-Y 10.1111/j.1365-2605.1981.tb00680.x |
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Snippet | Comparative genomic hybridization (CGH) was used to evaluate tissue specimens from 16 seminomas in order to elucidate the pathogenesis of germ cell tumours in... |
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SubjectTerms | Chromosome Aberrations Chromosome Banding Chromosome Deletion DNA, Neoplasm - analysis Genes, Neoplasm Humans Karyotyping Male Neoplasm Staging Nucleic Acid Hybridization Seminoma - genetics Seminoma - pathology Testicular Neoplasms - genetics Testicular Neoplasms - pathology |
Title | Detection of chromosomal aberrations in seminomatous germ cell tumours using comparative genomic hybridization |
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