Modified Korean MIND Diet: A Nutritional Intervention for Improved Cognitive Function in Elderly Women through Mitochondrial Respiration, Inflammation Suppression, and Amino Acid Metabolism Regulation

• Published in: Molecular nutrition & food research Vol. 67; no. 20; pp. e2300329 - n/a
• Main Authors: Kang, Eun Young, Kim, Do‐Young, Kim, Hyun Kyung, Shin, Weon‐Sun, Park, Young‐Sook, Kim, Tae Hoon, Kim, Wooki, Cao, Lei, Lee, Sang‐gil, Gang, Gyoungok, Shin, Minhye, Kim, Jun‐Mo, Go, Gwang‐woong
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.10.2023
• Subjects: Aged; alcohol drinking; amino acid metabolism; Amino Acids; ATP synthase; Biomarkers; brain; Cell membranes; Cognition; Cognitive ability; cognitive disorders; Cytochrome-c oxidase; cytokines; dementia; Dementia disorders; Diet; elderly; Electron transport; Female; fermented milk; Fermented milk products; food research; Genes; Glycine; H-transporting ATP synthase; Humans; Immune system; Inflammation; K‐MIND diet; Metabolic pathways; metabolome; mild cognitive impairment; milk; mitochondria; multiomics; multi‐omics analysis; neurotransmitters; nutritional intervention; Older people; Oxidative phosphorylation; perilla oil; Phosphorylation; Republic of Korea; Respiration; serine; Sphingolipids; Threonine; transcription factor NF-kappa B; transcriptome; Tryptophan; Ubiquinone oxidoreductase; ubiquinones; Republic of Korea; mild cognitive impairment; multi-omics analysis; K-MIND diet; transcriptome; metabolome
• ISSN: 1613-4125; 1613-4133; 1613-4133
• DOI: 10.1002/mnfr.202300329

Scope Mild cognitive impairment is associated with a high prevalence of dementia. The study examines the benefits of a modified Korean MIND (K‐MIND) diet and explores biomarkers using multi‐omics analysis. Methods and results The K‐MIND diet, tailored to the elderly Korean population, includes perilla oil, milk, or fermented milk, and avoids alcohol consumption. As a result, the K‐MIND diet significantly improves subjects “orientation to place” in the Korean version of the Mini‐Mental State Examination, 2nd edition test. According to multi‐omics analysis, the K‐MIND diet upregulates genes associated with mitochondrial respiration, including ubiquinone oxidoreductase, cytochrome C oxidase, and ATP synthase, and immune system processes, and downregulates genes related to nuclear factor kappa B activity and inflammatory responses. In addition, K‐MIND affects the metabolic pathways of glycine, serine, threonine, tryptophan, and sphingolipids, which are closely linked to cognitive function through synthesis of neurotransmitters and structures of brain cell membranes. Conclusion The findings imply that the K‐MIND diet improves cognitive function by upregulating key genes involved in oxidative phosphorylation and downregulating pro‐inflammatory cytokines. The modified K‐MIND diet intervention for 12 weeks on elderly Korean woman has evidence that improved cognitive function by upregulating oxidative phosphorylation and downregulating inflammatory response. In metabolites analysis, the modified K‐MIND diet stimulates metabolites associated with neurotransmitters synthesis and cell membranes structure. In conclusion, modified K‐MIND diet has beneficial effect for preventing cognitive dysfunction.