Vitamin D Deficiency in Rats Causes Cardiac Dysfunction by Inducing Myocardial Insulin Resistance

• Published in: Molecular nutrition & food research Vol. 63; no. 17; pp. e1900109 - n/a
• Main Authors: Nizami, Hina Lateef, Katare, Parmeshwar, Prabhakar, Pankaj, Kumar, Yashwant, Arava, Sudheer Kumar, Chakraborty, Praloy, Maulik, Subir Kumar, Banerjee, Sanjay Kumar
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.09.2019
• Subjects: 25-Hydroxyvitamin D; Abnormalities; AKT protein; Animals; Blood pressure; blood serum; Calciferol; Calcitriol; cardiac remodeling; Cardiomegaly; Catalase; Cholesterol; Collagen; Congestive heart failure; Diet; Dyslipidemias - etiology; Echocardiography; Fetuses; Fibrosis; Fructose; Gene Expression Regulation; genes; Glucose; Glucose - metabolism; Glucose tolerance; glucose transporters; Heart; Heart - physiopathology; heart failure; High density lipoprotein; high density lipoprotein cholesterol; High fat diet; high fructose diet; Hyperinsulinism - etiology; Hypertension - etiology; Hypertrophy; Hypertrophy, Left Ventricular - etiology; Insulin; Insulin Resistance; interleukin-6; Male; males; messenger RNA; Metabolic disorders; Metabolic syndrome; Myocardium - metabolism; Nutrient deficiency; Palmitic acid; Phosphorylation; rats; Rats, Sprague-Dawley; Receptors, Calcitriol - genetics; Renin; Renin - genetics; Risk analysis; Risk factors; Superoxide dismutase; transcription factor NF-kappa B; transforming growth factor beta; Translocation; triacylglycerols; Triglycerides; tumor necrosis factor-alpha; Ventricular Remodeling; Vitamin D; vitamin D deficiency; Vitamin D Deficiency - complications; Vitamin D Deficiency - genetics; Vitamin D Deficiency - physiopathology; Vitamin deficiency; metabolic syndrome; heart failure; insulin resistance; vitamin D deficiency; cardiac remodeling

Scope Cause‐effect relationship between vitamin D deficiency and cardiometabolic abnormalities remains undefined. The aim is to investigate the role of vitamin D deficiency in cardiac failure, through possible involvement in myocardial insulin signaling. Methods and results Male SD rats (n = 6) are...