Yellow Yeast Rice Prepared Using Aspergillus terreus DSMK01 Lowers Cholesterol Levels by Stimulating Bile Salt Export Pump in Subjects with Mild‐to‐Moderate Hypercholesterolemia: A Randomized Controlled Trial

• Published in: Molecular nutrition & food research Vol. 66; no. 1; pp. e2100704 - n/a
• Main Authors: Kang, Seunghee, Lee, Eunok, Lee, Heeyeon, Hwang, Geum‐Sook, Lee, Jaekyung, Kim, Ji Won, Oh, Bumjo, Kim, Ji Yeon, Kwon, Oran
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.01.2022
• Subjects: absorption; Aspergillus - metabolism; Aspergillus terreus; ATP Binding Cassette Transporter, Subfamily B, Member 11 - metabolism; Availability; Bile; bile acid metabolite; Bile acids; Bile Acids and Salts - metabolism; Bile salts; Biological Products - therapeutic use; Biosynthesis; Brewing; Cholesterol; cholesterol metabolism; Clinical trials; Dietary fiber; exports; food research; fungal fermentation; Gene expression; genes; human clinical trial; Humans; Hydroxymethylglutaryl-CoA reductase; Hypercholesterolemia; LDLR gene; Liver - metabolism; lovastatin; Low density lipoprotein; low density lipoprotein receptors; Metabolomics; monacolin K; nutrition; oxidoreductases; Placebos; Plasma; randomized clinical trials; Reductases; Rice; Salts; Supplements; transporters; Yeast; yeasts; human clinical trial; monacolin K; bile acid metabolite; cholesterol metabolism; fungal fermentation

Scope Aspergillus terreus is an industrial microorganism used in the brewing and sauce industries. It produces monacolin K, a natural statin. The study conducted an 8‐week randomized controlled trial with hypercholesterolemic subjects to examine the hypocholesterolemic effects and mechanisms of supp...