C-reactive protein, an 'intermediate phenotype' for inflammation: human twin studies reveal heritability, association with blood pressure and the metabolic syndrome, and the influence of common polymorphism at catecholaminergic/beta-adrenergic pathway loci

• Published in: Journal of hypertension Vol. 25; no. 2; p. 329
• Main Authors: Wessel, Jennifer, Moratorio, Guillermo, Rao, Fangwen, Mahata, Manjula, Zhang, Lian, Greene, William, Rana, Brinda K, Kennedy, Brian P, Khandrika, Srikrishna, Huang, Pauline, Lillie, Elizabeth O, Shih, Pei-An Betty, Smith, Douglas W, Wen, Gen, Hamilton, Bruce A, Ziegler, Michael G, Witztum, Joseph L, Schork, Nicholas J, Schmid-Schönbein, Geert W, O'Connor, Daniel T
• Format: Journal Article
• Language: English
• Published: England 01.02.2007
• Subjects: Adult; Body Mass Index; C-Reactive Protein - analysis; C-Reactive Protein - genetics; C-Reactive Protein - immunology; Catecholamines - analysis; Catecholamines - metabolism; Coronary Artery Disease - genetics; Coronary Artery Disease - immunology; Epistasis, Genetic; Female; Humans; Hypertension - blood; Hypertension - genetics; Inflammation - genetics; Inflammation - physiopathology; Inheritance Patterns; Male; Metabolic Syndrome - blood; Metabolic Syndrome - genetics; Metabolic Syndrome - immunology; Microsatellite Repeats; Polymorphism, Single Nucleotide; Receptors, Adrenergic, beta - genetics; Tyrosine 3-Monooxygenase - genetics

C-reactive protein (CRP) both reflects and participates in inflammation, and its circulating concentration marks cardiovascular risk. Here we sought to understand the role of heredity in determining CRP secretion. CRP, as well as multiple facets of the metabolic syndrome, were measured in a series o...