Betaine Delayed Muscle Loss by Attenuating Samtor Complex Inhibition for mTORC1 Signaling Via Increasing SAM Level

• Published in: Molecular nutrition & food research Vol. 65; no. 15; pp. e2100157 - n/a
• Main Authors: Chen, Si, Lu, Xiao‐Ting, He, Tong‐Tong, Yishake, Dinuerguli, Tan, Xu‐Yin, Hou, Meng‐Jun, Luo, Yun, Long, Jing‐An, Tang, Zhi‐Hong, Zhong, Rong‐Huan, Fang, Ai‐Ping, Zhu, Hui‐Lian
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.08.2021
• Subjects: age‐related muscle loss; Aging; Aging - drug effects; Aging - pathology; Animals; Betaine; Betaine - pharmacology; Body composition; diet; Dietary supplements; Distilled water; elderly; food research; Gene Expression Regulation - drug effects; Geriatrics; Grip strength; Intracellular Membranes - drug effects; Intracellular Membranes - metabolism; Intracellular Signaling Peptides and Proteins - antagonists & inhibitors; Kinases; Liquid chromatography; lysosomes; Lysosomes - drug effects; Lysosomes - metabolism; Male; males; Mechanistic Target of Rapamycin Complex 1 - metabolism; Methionine; Methionine - metabolism; Methyltransferases - antagonists & inhibitors; Mice; Mice, Inbred C57BL; Morphology; mTORC1; muscle protein; muscle strength; Muscle, Skeletal - drug effects; Muscle, Skeletal - metabolism; Muscle, Skeletal - physiopathology; Muscles; Myosin; myosin heavy chains; Older people; Protein biosynthesis; Protein Biosynthesis - drug effects; Protein kinase; protein kinases; Protein synthesis; Proteins; Rapamycin; S-adenosylmethionine; S-Adenosylmethionine - metabolism; Samtor; Signal Transduction - drug effects; Signaling; S‐adenosylmethionine (SAM); Tethering; TOR protein; ultra-performance liquid chromatography; S-adenosylmethionine (SAM); age-related muscle loss; Samtor; betaine; mTORC1

Scope The muscle loss during aging results from the blunt of protein synthesis and poses threat to the elderly health. This study aims to investigate whether betaine affects muscle loss by improving protein synthesis. Methods and Results Male C57BL/6J mice are raised from age 12 or 15 months. Mice a...