Betaine Delayed Muscle Loss by Attenuating Samtor Complex Inhibition for mTORC1 Signaling Via Increasing SAM Level - Chen, Si; Lu, Xiao‐Ting; He, Tong‐Tong; Yishake, Dinuerguli; Tan, Xu‐Yin; Hou, Meng‐Jun; Luo, Yun; Long, Jing‐An; Tang, Zhi‐Hong; Zhong, Rong‐Huan; Fang, Ai‐Ping; Zhu, Hui‐Lian (Molecular nutrition & food research, 2021)
Keywords: age‐related muscle loss; Aging; Aging - drug effects; Aging - pathology; Animals; Betaine; Betaine - pharmacology; Body composition; diet; Dietary supplements; Distilled water; elderly; food research; Gene Expression Regulation - drug effects; Geriatrics; Grip strength; Intracellular Membranes - drug effects; Intracellular Membranes - metabolism; Intracellular Signaling Peptides and Proteins - antagonists & inhibitors; Kinases; Liquid chromatography; lysosomes; Lysosomes - drug effects; Lysosomes - metabolism; Male; males; Mechanistic Target of Rapamycin Complex 1 - metabolism; Methionine; Methionine - metabolism; Methyltransferases - antagonists & inhibitors; Mice; Mice, Inbred C57BL; Morphology; mTORC1; muscle protein; muscle strength; Muscle, Skeletal - drug effects; Muscle, Skeletal - metabolism; Muscle, Skeletal - physiopathology; Muscles; Myosin; myosin heavy chains; Older people; Protein biosynthesis; Protein Biosynthesis - drug effects; Protein kinase; protein kinases; Protein synthesis; Proteins; Rapamycin; S-adenosylmethionine; S-Adenosylmethionine - metabolism; Samtor; Signal Transduction - drug effects; Signaling; S‐adenosylmethionine (SAM); Tethering; TOR protein; ultra-performance liquid chromatography; S-adenosylmethionine (SAM); age-related muscle loss; Samtor; betaine; mTORC1