Morphine Dose Optimization in Critically Ill Pediatric Patients With Acute Respiratory Failure: A Population Pharmacokinetic-Pharmacogenomic Study

• Published in: Critical care medicine Vol. 47; no. 6; p. e485
• Main Authors: Zuppa, Athena F, Benitez, Giselle R, Zane, Nicole R, Curley, Martha A Q, Bradfield, Jonathan, Hakonarson, Hakon, Gastonguay, Madeleine S, Moorthy, Ganesh, Prodell, Janice, Gastonguay, Marc R
• Format: Journal Article
• Language: English
• Published: United States 01.06.2019
• Subjects: Acute Disease; Adolescent; Age Factors; Analgesics, Opioid - administration & dosage; Analgesics, Opioid - blood; Analgesics, Opioid - pharmacokinetics; Body Weight; Child; Child, Preschool; Critical Illness; Female; Genotype; Glucuronosyltransferase - genetics; Humans; Infant; Male; Morphine - administration & dosage; Morphine - blood; Morphine - pharmacokinetics; Morphine Derivatives - blood; Pharmacogenomic Testing; Prospective Studies; Respiration, Artificial; Respiratory Insufficiency - therapy; Time Factors

To develop a pharmacokinetic-pharmacogenomic population model of morphine in critically ill children with acute respiratory failure. Prospective pharmacokinetic-pharmacogenomic observational study. Thirteen PICUs across the United States. Pediatric subjects (n = 66) mechanically ventilated for acute...