Morphine Dose Optimization in Critically Ill Pediatric Patients With Acute Respiratory Failure: A Population Pharmacokinetic-Pharmacogenomic Study - Zuppa, Athena F; Benitez, Giselle R; Zane, Nicole R; Curley, Martha A Q; Bradfield, Jonathan; Hakonarson, Hakon; Gastonguay, Madeleine S; Moorthy, Ganesh; Prodell, Janice; Gastonguay, Marc R (Critical care medicine, 2019)
Keywords: Acute Disease; Adolescent; Age Factors; Analgesics, Opioid - administration & dosage; Analgesics, Opioid - blood; Analgesics, Opioid - pharmacokinetics; Body Weight; Child; Child, Preschool; Critical Illness; Female; Genotype; Glucuronosyltransferase - genetics; Humans; Infant; Male; Morphine - administration & dosage; Morphine - blood; Morphine - pharmacokinetics; Morphine Derivatives - blood; Pharmacogenomic Testing; Prospective Studies; Respiration, Artificial; Respiratory Insufficiency - therapy; Time Factors