Alpha‐Linolenic Acid Supplementation Improves Testosterone Production in an Aged Breeder Rooster Model: Role of Mitochondrial Modulation and SIRT1 Activation

• Published in: Molecular nutrition & food research Vol. 68; no. 22; pp. e2400522 - n/a
• Main Authors: Long, Cheng, Zhao, Zhi‐xian, Willing, Benjamin P., Sheng, Xi‐Hui, Wang, Xiang‐Guo, Xiao, Long‐Fei, Qi, Xiao‐Long
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.11.2024
• Subjects: Aging; alpha-linolenic acid; alpha-Linolenic Acid - administration & dosage; alpha-Linolenic Acid - pharmacology; Animals; Apoptosis; B-cell lymphoma; biogenesis; Biosynthesis; breeder roosters; Cell culture; Dietary Supplements; food research; Genes; In vivo methods and tests; Leydig cells; Leydig Cells - drug effects; Leydig Cells - metabolism; Linolenic acid; Lymphoma; Male; Mitochondria; Mitochondria - drug effects; Mitochondria - metabolism; mitochondrial function; Modulation; Molecular modelling; Reproductive health; roosters; siRNA; SIRT1 pathway; SIRT1 protein; Sirtuin 1 - genetics; Sirtuin 1 - metabolism; Testis - drug effects; Testis - metabolism; Testosterone; testosterone production; mitochondrial function; SIRT1 pathway; alpha‐linolenic acid; breeder roosters; testosterone production; Leydig cells

Scope Aging in males can lead to declines in testosterone production, essential for maintaining male reproductive health. Methods and results To investigate the effects of dietary supplementation with alpha‐linolenic acid (ALA) on testosterone production in aged breeder roosters and understand the u...