Single-Cell RNA Sequencing Analysis Reveals Sequential Cell Fate Transition during Human Spermatogenesis

• Published in: Cell stem cell Vol. 23; no. 4; pp. 599 - 614.e4
• Main Authors: Wang, Mei, Liu, Xixi, Chang, Gang, Chen, Yidong, An, Geng, Yan, Liying, Gao, Shuai, Xu, Yanwen, Cui, Yueli, Dong, Ji, Chen, Yuhan, Fan, Xiaoying, Hu, Yuqiong, Song, Ke, Zhu, Xiaohui, Gao, Yun, Yao, Zhaokai, Bian, Shuhui, Hou, Yu, Lu, Jiahao, Wang, Rui, Fan, Yong, Lian, Ying, Tang, Wenhao, Wang, Yapeng, Liu, Jianqiao, Zhao, Lianming, Wang, Luyu, Liu, Zhaoting, Yuan, Renpei, Shi, Yujia, Hu, Boqiang, Ren, Xiulian, Tang, Fuchou, Zhao, Xiao-Yang, Qiao, Jie
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 04.10.2018
• Subjects: human spermatogenesis; single-cell RNA sequencing; single-cell RNA sequencing; human spermatogenesis

Spermatogenesis generates mature male gametes and is critical for the proper transmission of genetic information between generations. However, the developmental landscapes of human spermatogenesis remain unknown. Here, we performed single-cell RNA sequencing (scRNA-seq) analysis for 2,854 testicular...