Oxidative stress-mediated memory impairment during aging and its therapeutic intervention by natural bioactive compounds

Aging and associated neurodegenerative diseases are accompanied by the decline of several brain functions including cognitive abilities. Progressive deleterious changes at biochemical and physiological levels lead to the generation of oxidative stress, accumulation of protein aggregates, mitochondri...

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Published inFrontiers in aging neuroscience Vol. 14; p. 944697
Main Authors Singh, Padmanabh, Barman, Bhabotosh, Thakur, Mahendra Kumar
Format Journal Article
LanguageEnglish
Published Lausanne Frontiers Research Foundation 25.07.2022
Frontiers Media S.A
Subjects
Age
Aging
Alzheimer's disease
Animal cognition
Antioxidants
Bioactive compounds
Cognitive ability
Enzymes
Fatty acids
Free radicals
Homeostasis
Lipid peroxidation
Lipids
Memory
Mitochondria
Mitochondrial DNA
Neurodegeneration
Neurodegenerative diseases
Neuroscience
Oxidation
Oxidative stress
Phosphorylation
Physiology
Plants
Proteins
Synapses
Theories of aging
Online AccessGet full text
ISSN1663-4365
1663-4365
DOI10.3389/fnagi.2022.944697

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Abstract Aging and associated neurodegenerative diseases are accompanied by the decline of several brain functions including cognitive abilities. Progressive deleterious changes at biochemical and physiological levels lead to the generation of oxidative stress, accumulation of protein aggregates, mitochondrial dysfunctions, loss of synaptic connections, and ultimately neurodegeneration and cognitive decline during aging. Oxidative stress that arises due to an imbalance between the rates of production and elimination of free radicles is the key factor for age-associated neurodegeneration and cognitive decline. Due to high energy demand, the brain is more susceptible to free radicals-mediated damages as they oxidize lipids, proteins, and nucleic acids, thereby causing an imbalance in the homeostasis of the aging brain. Animal, as well as human subject studies, showed that with almost no or few side effects, dietary interventions and plant-derived bioactive compounds could be beneficial to recovering the memory or delaying the onset of memory impairment. As the plant-derived bioactive compounds have antioxidative properties, several of them were used to recover the oxidative stress-mediated changes in the aging brain. In the present article, we review different aspects of oxidative stress-mediated cognitive change during aging and its therapeutic intervention by natural bioactive compounds.
AbstractList Aging and associated neurodegenerative diseases are accompanied by the decline of several brain functions including cognitive abilities. Progressive deleterious changes at biochemical and physiological levels lead to the generation of oxidative stress, accumulation of protein aggregates, mitochondrial dysfunctions, loss of synaptic connections, and ultimately neurodegeneration and cognitive decline during aging. Oxidative stress that arises due to an imbalance between the rates of production and elimination of free radicles is the key factor for age-associated neurodegeneration and cognitive decline. Due to high energy demand, the brain is more susceptible to free radicals-mediated damages as they oxidize lipids, proteins, and nucleic acids, thereby causing an imbalance in the homeostasis of the aging brain. Animal, as well as human subject studies, showed that with almost no or few side effects, dietary interventions and plant-derived bioactive compounds could be beneficial to recovering the memory or delaying the onset of memory impairment. As the plant-derived bioactive compounds have antioxidative properties, several of them were used to recover the oxidative stress-mediated changes in the aging brain. In the present article, we review different aspects of oxidative stress-mediated cognitive change during aging and its therapeutic intervention by natural bioactive compounds.Aging and associated neurodegenerative diseases are accompanied by the decline of several brain functions including cognitive abilities. Progressive deleterious changes at biochemical and physiological levels lead to the generation of oxidative stress, accumulation of protein aggregates, mitochondrial dysfunctions, loss of synaptic connections, and ultimately neurodegeneration and cognitive decline during aging. Oxidative stress that arises due to an imbalance between the rates of production and elimination of free radicles is the key factor for age-associated neurodegeneration and cognitive decline. Due to high energy demand, the brain is more susceptible to free radicals-mediated damages as they oxidize lipids, proteins, and nucleic acids, thereby causing an imbalance in the homeostasis of the aging brain. Animal, as well as human subject studies, showed that with almost no or few side effects, dietary interventions and plant-derived bioactive compounds could be beneficial to recovering the memory or delaying the onset of memory impairment. As the plant-derived bioactive compounds have antioxidative properties, several of them were used to recover the oxidative stress-mediated changes in the aging brain. In the present article, we review different aspects of oxidative stress-mediated cognitive change during aging and its therapeutic intervention by natural bioactive compounds.
Aging and associated neurodegenerative diseases are accompanied by the decline of several brain functions including cognitive abilities. Progressive deleterious changes at biochemical and physiological levels lead to the generation of oxidative stress, accumulation of protein aggregates, mitochondrial dysfunctions, loss of synaptic connections, and ultimately neurodegeneration and cognitive decline during aging. Oxidative stress that arises due to an imbalance between the rates of production and elimination of free radicles is the key factor for age-associated neurodegeneration and cognitive decline. Due to high energy demand, the brain is more susceptible to free radicals-mediated damages as they oxidize lipids, proteins, and nucleic acids, thereby causing an imbalance in the homeostasis of the aging brain. Animal, as well as human subject studies, showed that with almost no or few side effects, dietary interventions and plant-derived bioactive compounds could be beneficial to recovering the memory or delaying the onset of memory impairment. As the plant-derived bioactive compounds have antioxidative properties, several of them were used to recover the oxidative stress-mediated changes in the aging brain. In the present article, we review different aspects of oxidative stress-mediated cognitive change during aging and its therapeutic intervention by natural bioactive compounds.
Aging and associated neurodegenerative diseases are accompanied by the decline of several brain functions including cognitive abilities. Progressive deleterious changes at biochemical and physiological levels lead to generation of oxidative stress, accumulation of protein aggregates, mitochondrial dysfunctions, loss of synaptic connections, and ultimately neurodegeneration and cognitive decline during aging. Oxidative stress that arises due to an imbalance between the rates of production and elimination of free radicles is the key factor for age-associated neurodegeneration and cognitive decline. Due to high energy demand, the brain is more susceptible to free radicals-mediated damages as they oxidize lipids, proteins, and nucleic acids, thereby causing an imbalance in the homeostasis of the aging brain. Animal, as well as human subject studies, showed that, with almost no or few side effects, dietary interventions and plant-derived bioactive compounds could be beneficial to recovering memory or delay the onset of memory impairment. As the plant-derived bioactive compounds have antioxidative properties, several of them were used to recover the oxidative stress-mediated changes in the aging brain. In the present article, we review different aspects of oxidative stress-mediated cognitive change during aging and its therapeutic intervention by natural bioactive compounds.
Author Barman, Bhabotosh
Singh, Padmanabh
Thakur, Mahendra Kumar
AuthorAffiliation 2 Department of Zoology, Indira Gandhi National Tribal University , Amarkantak , India
1 Department of Zoology, Banaras Hindu University , Varanasi , India
AuthorAffiliation_xml – name: 2 Department of Zoology, Indira Gandhi National Tribal University , Amarkantak , India
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Copyright © 2022 Singh, Barman and Thakur.
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These authors have contributed equally to this work and share first authorship
Edited by: Ignacio Torres-Aleman, Achucarro Basque Center for Neuroscience, Spain
Reviewed by: Masami Kojima, Kanazawa Institute of Technology, Japan; Wen Xiong, Baylor College of Medicine, United States
This article was submitted to Neurocognitive Aging and Behavior, a section of the journal Frontiers in Aging Neuroscience
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Snippet Aging and associated neurodegenerative diseases are accompanied by the decline of several brain functions including cognitive abilities. Progressive...
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SubjectTerms Age
Aging
Alzheimer's disease
Animal cognition
Antioxidants
Bioactive compounds
Cognitive ability
Enzymes
Fatty acids
Free radicals
Homeostasis
Lipid peroxidation
Lipids
Memory
Mitochondria
Mitochondrial DNA
Neurodegeneration
Neurodegenerative diseases
Neuroscience
Oxidation
Oxidative stress
Phosphorylation
Physiology
Plants
Proteins
Synapses
Theories of aging
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Title Oxidative stress-mediated memory impairment during aging and its therapeutic intervention by natural bioactive compounds
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