Quantification of endogenous Angiotensin 1-10, 1-9, 1-8, 1-7, and 1-5 in human plasma using micro-UHPLC-MS/MS: Outlining the importance of the pre-analytics for reliable results

• Published in: Journal of pharmaceutical and biomedical analysis Vol. 243; p. 116101
• Main Authors: Maurer, Jonathan, de Groot, Anke, Martin, Léon, Grouzmann, Eric, Wuerzner, Grégoire, Eugster, Philippe J.
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 15.06.2024
• Subjects: ACE; Angiotensin; Angiotensins; Chromatography, High Pressure Liquid; Humans; Hypertension; Mass spectrometry; Peptides; Preanalytical stability; Reproducibility of Results; Tandem Mass Spectrometry - methods; Hypertension; ACE; Preanalytical stability; Mass spectrometry; Angiotensin

Angiotensin peptides (ANGs) play a central role in the renin–angiotensin–aldosterone system, rendering them interesting biomarkers associated with hypertension. Precise quantification of circulating ANGs holds the potential to assess the activity of angiotensin-converting enzyme (ACE), a key proteas...