Bioorganometallic chemistry—from teaching paradigms to medicinal applications

• Published in: Chemical Society reviews Vol. 38; no. 2; pp. 391 - 401
• Main Authors: Hartinger, Christian G., Dyson, Paul J.
• Format: Journal Article
• Language: English
• Published: England 26.01.2009
• Subjects: air; Animals; biochemical compounds; carbon; catalytic activity; Crystallography, X-Ray; Human immunodeficiency virus; Humans; ligands; malaria; medicinal properties; medicine; neoplasms; organometallic compounds; Organometallic Compounds - chemistry; Organometallic Compounds - pharmacology; Pharmaceutical Preparations - chemistry; Porphyrins - chemistry; Radiopharmaceuticals - chemistry; Radiopharmaceuticals - pharmacology; therapeutics; toxicity

In undergraduate level organometallic chemistry courses students are usually taught that organometallic compounds are toxic and unstable in air and water. While this is true of many complexes, some are also non-toxic and stable in air and water. Indeed, bioorganometallic chemistry, the study of biom...