The importance of pre-formulation studies and of 3D-printed nasal casts in the success of a pharmaceutical product intended for nose-to-brain delivery

• Published in: Advanced drug delivery reviews Vol. 175; p. 113826
• Main Authors: Deruyver, Laura, Rigaut, Clément, Lambert, Pierre, Haut, Benoît, Goole, Jonathan
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.08.2021
• Subjects: 3D printing; Administration devices; Administration, Intranasal - methods; Animals; Brain - drug effects; Brain Diseases - drug therapy; Drug Compounding - methods; Formulation properties; Humans; Nasal casts; Nasal Cavity - anatomy & histology; Nose-to-brain; Olfactory region; Pre-formulation studies; Printing, Three-Dimensional; Treatment effectiveness; Nasal casts; Formulation properties; Treatment effectiveness; Administration devices; Pre-formulation studies; Olfactory region; Nose-to-brain; 3D printing

[Display omitted] •A framework to develop nose-to-brain drugs combining pharmaceutics and engineering.•The importance of the pre-formulation for safe, stable and efficient formulation.•The selection of the administration device to target the olfactory zone.•The 3D-printing of nasal casts to check th...