The importance of pre-formulation studies and of 3D-printed nasal casts in the success of a pharmaceutical product intended for nose-to-brain delivery
[Display omitted] •A framework to develop nose-to-brain drugs combining pharmaceutics and engineering.•The importance of the pre-formulation for safe, stable and efficient formulation.•The selection of the administration device to target the olfactory zone.•The 3D-printing of nasal casts to check th...
Saved in:
| Published in | Advanced drug delivery reviews Vol. 175; p. 113826 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
01.08.2021
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | [Display omitted]
•A framework to develop nose-to-brain drugs combining pharmaceutics and engineering.•The importance of the pre-formulation for safe, stable and efficient formulation.•The selection of the administration device to target the olfactory zone.•The 3D-printing of nasal casts to check the suitability of formulation properties.
This review aims to cement three hot topics in drug delivery: (a) the pre-formulation of new products intended for nose-to-brain delivery; (b) the development of nasal casts for studying the efficacy of potential new nose-to-brain delivery systems at the early of their development (pre-formulation); (c) the use of 3D printing based on a wide variety of materials (transparent, biocompatible, flexible) providing an unprecedented fabrication tool towards personalized medicine by printing nasal cast on-demand based on CT scans of patients.
This review intends to show the links between these three subjects. Indeed, the pathway selected to administrate the drug to the brain not only influence the formulation strategies to implement but also the design of the cast, to get the most convincing measures from it. Moreover, the design of the cast himself influences the choice of the 3D-printing technology, which, in its turn, bring more constraints to the nasal replica design. Consequently, the formulation of the drug, the cast preparation and its realisation should be thought of as a whole and not separately. |
|---|---|
| AbstractList | This review aims to cement three hot topics in drug delivery: (a) the pre-formulation of new products intended for nose-to-brain delivery; (b) the development of nasal casts for studying the efficacy of potential new nose-to-brain delivery systems at the early of their development (pre-formulation); (c) the use of 3D printing based on a wide variety of materials (transparent, biocompatible, flexible) providing an unprecedented fabrication tool towards personalized medicine by printing nasal cast on-demand based on CT scans of patients. This review intends to show the links between these three subjects. Indeed, the pathway selected to administrate the drug to the brain not only influence the formulation strategies to implement but also the design of the cast, to get the most convincing measures from it. Moreover, the design of the cast himself influences the choice of the 3D-printing technology, which, in its turn, bring more constraints to the nasal replica design. Consequently, the formulation of the drug, the cast preparation and its realisation should be thought of as a whole and not separately.This review aims to cement three hot topics in drug delivery: (a) the pre-formulation of new products intended for nose-to-brain delivery; (b) the development of nasal casts for studying the efficacy of potential new nose-to-brain delivery systems at the early of their development (pre-formulation); (c) the use of 3D printing based on a wide variety of materials (transparent, biocompatible, flexible) providing an unprecedented fabrication tool towards personalized medicine by printing nasal cast on-demand based on CT scans of patients. This review intends to show the links between these three subjects. Indeed, the pathway selected to administrate the drug to the brain not only influence the formulation strategies to implement but also the design of the cast, to get the most convincing measures from it. Moreover, the design of the cast himself influences the choice of the 3D-printing technology, which, in its turn, bring more constraints to the nasal replica design. Consequently, the formulation of the drug, the cast preparation and its realisation should be thought of as a whole and not separately. This review aims to cement three hot topics in drug delivery: (a) the pre-formulation of new products intended for nose-to-brain delivery; (b) the development of nasal casts for studying the efficacy of potential new nose-to-brain delivery systems at the early of their development (pre-formulation); (c) the use of 3D printing based on a wide variety of materials (transparent, biocompatible, flexible) providing an unprecedented fabrication tool towards personalized medicine by printing nasal cast on-demand based on CT scans of patients. This review intends to show the links between these three subjects. Indeed, the pathway selected to administrate the drug to the brain not only influence the formulation strategies to implement but also the design of the cast, to get the most convincing measures from it. Moreover, the design of the cast himself influences the choice of the 3D-printing technology, which, in its turn, bring more constraints to the nasal replica design. Consequently, the formulation of the drug, the cast preparation and its realisation should be thought of as a whole and not separately. [Display omitted] •A framework to develop nose-to-brain drugs combining pharmaceutics and engineering.•The importance of the pre-formulation for safe, stable and efficient formulation.•The selection of the administration device to target the olfactory zone.•The 3D-printing of nasal casts to check the suitability of formulation properties. This review aims to cement three hot topics in drug delivery: (a) the pre-formulation of new products intended for nose-to-brain delivery; (b) the development of nasal casts for studying the efficacy of potential new nose-to-brain delivery systems at the early of their development (pre-formulation); (c) the use of 3D printing based on a wide variety of materials (transparent, biocompatible, flexible) providing an unprecedented fabrication tool towards personalized medicine by printing nasal cast on-demand based on CT scans of patients. This review intends to show the links between these three subjects. Indeed, the pathway selected to administrate the drug to the brain not only influence the formulation strategies to implement but also the design of the cast, to get the most convincing measures from it. Moreover, the design of the cast himself influences the choice of the 3D-printing technology, which, in its turn, bring more constraints to the nasal replica design. Consequently, the formulation of the drug, the cast preparation and its realisation should be thought of as a whole and not separately. |
| ArticleNumber | 113826 |
| Author | Deruyver, Laura Haut, Benoît Rigaut, Clément Lambert, Pierre Goole, Jonathan |
| Author_xml | – sequence: 1 givenname: Laura surname: Deruyver fullname: Deruyver, Laura organization: Laboratoire de Pharmacie Galénique et de Biopharmacie, Université libre de Bruxelles (ULB), Brussels, Belgium – sequence: 2 givenname: Clément orcidid: 0000-0003-4999-8601 surname: Rigaut fullname: Rigaut, Clément organization: TIPs (Transfers, Interfaces and Processes), Université libre de Bruxelles, Brussels, Belgium – sequence: 3 givenname: Pierre orcidid: 0000-0001-7604-0584 surname: Lambert fullname: Lambert, Pierre organization: TIPs (Transfers, Interfaces and Processes), Université libre de Bruxelles, Brussels, Belgium – sequence: 4 givenname: Benoît surname: Haut fullname: Haut, Benoît organization: TIPs (Transfers, Interfaces and Processes), Université libre de Bruxelles, Brussels, Belgium – sequence: 5 givenname: Jonathan surname: Goole fullname: Goole, Jonathan email: jonathan.goole@ulb.be organization: Laboratoire de Pharmacie Galénique et de Biopharmacie, Université libre de Bruxelles (ULB), Brussels, Belgium |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34119575$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kb1u3SAYhlGVqDlJegMdKsYuPgWMbSx1qZL-SZG6JFI29Bk-KxzZ4AKOlBvp9Rb3JEuHTB54nhfzvufkxAePhLznbM8Zbz8d9mBt3Asm-J7zWon2Ddlx1YlKiV6ekF2B-kqy_v6MnKd0YIyLrmVvyVktOe-brtmRP7cPSN28hJjBG6RhpEvEagxxXifILnia8modJgrebsf1dbVE5zNa6iHBRA2knKjzNJeotBqDKW0g0OUB4gwG1-xMAZcY7Goy3WRvi19uoT4krHKohgglwuLkHjE-XZLTEaaE756_F-Tu29fbqx_Vza_vP6--3FRGMpYrNHIYea9qy_oWeqV4Df3AZCMkcmyZVBKFUEPPuRobgEGp1rTNOMh6ZNDZ-oJ8POaWf_u9Ysp6dsngNIHHsCYtGsm6UmnbFPTDM7oOM1pdSpghPumXLgugjoCJIaWIozYu_6swl7dNmjO9zaYPeptNb7Pp42xFFf-pL-mvSp-PEpaCHh1GnYzDMqJ1EU3WNrjX9L_JIrJd |
| CitedBy_id | crossref_primary_10_3390_app122010585 crossref_primary_10_1080_02786826_2024_2394593 crossref_primary_10_3389_fmedt_2022_924501 crossref_primary_10_1016_j_curtheres_2023_100714 crossref_primary_10_1021_acsami_4c16024 crossref_primary_10_1021_acs_molpharmaceut_3c00639 crossref_primary_10_1080_17425247_2024_2336494 crossref_primary_10_1021_acsnano_4c08279 crossref_primary_10_1016_j_jmsy_2025_02_017 crossref_primary_10_1080_17425247_2025_2454476 crossref_primary_10_1002_adfm_202419914 crossref_primary_10_1016_j_addr_2022_114485 crossref_primary_10_3390_ph14080711 crossref_primary_10_1016_j_ijpharm_2024_123896 crossref_primary_10_35414_akufemubid_1332603 crossref_primary_10_1016_j_ijbiomac_2025_140024 crossref_primary_10_1080_17425247_2024_2339335 crossref_primary_10_1208_s12248_025_01045_6 crossref_primary_10_3389_fddev_2022_995489 crossref_primary_10_1016_j_heliyon_2024_e38179 crossref_primary_10_1016_j_ijpharm_2022_121720 crossref_primary_10_2147_IJN_S397650 crossref_primary_10_3390_pharmaceutics15122661 crossref_primary_10_3390_pharmaceutics14050956 crossref_primary_10_3390_pharmaceutics15030892 crossref_primary_10_1016_j_ijpharm_2023_123345 crossref_primary_10_2147_IJN_S497480 crossref_primary_10_1016_j_ijpharm_2024_124851 crossref_primary_10_1080_17425247_2023_2274902 crossref_primary_10_3390_pharmaceutics14071353 crossref_primary_10_3390_pharmaceutics15061660 crossref_primary_10_1080_17425247_2025_2467784 crossref_primary_10_3390_pharmaceutics15061641 |
| Cites_doi | 10.3390/pharmaceutics11080367 10.1021/acs.chemrev.7b00074 10.1109/JPROC.2016.2625098 10.1002/alr.21199 10.1021/acs.molpharmaceut.0c00170 10.1051/matecconf/202032801006 10.1016/j.ijpharm.2017.04.077 10.1152/japplphysiol.90376.2008 10.1016/j.ijpharm.2020.120040 10.1016/j.jddst.2019.06.014 10.1080/17425247.2018.1429401 10.1080/10717544.2018.1428242 10.1016/j.msec.2019.03.101 10.1016/j.ijpharm.2013.03.034 10.1080/03639045.2018.1425426 10.4193/Rhin19.314 10.1007/s11095-019-2662-z 10.1208/s12249-016-0581-4 10.1021/acs.molpharmaceut.7b00702 10.3109/03639045.2015.1052081 10.1016/j.powtec.2016.01.042 10.1016/j.ijpharm.2010.03.017 10.1016/j.ijpharm.2019.01.030 10.3390/ijms21145016 10.1080/027868290883432 10.1088/1748-605X/ab09c4 10.1111/jphp.13316 10.1016/j.ijpharm.2020.119341 10.1021/acs.molpharmaceut.0c00672 10.1002/jps.22742 10.1021/acsomega.8b03445 10.1111/jopr.12928 10.1007/s00405-009-1073-x 10.1016/j.jconrel.2016.05.034 10.1007/s11095-009-9871-9 10.1089/jamp.2019.1549 10.1177/0194599811427519 10.1080/17425247.2020.1714589 10.4193/Rhin09.133 10.1007/s13233-013-1029-2 10.3109/1061186X.2015.1020809 10.1080/10837450.2019.1567762 10.1586/erd.12.58 10.1183/09031936.93.04030311 10.2147/IJN.S210876 10.1016/j.jddst.2015.12.004 10.1007/s11095-016-1896-2 10.1016/j.apsb.2016.04.001 10.1108/RPJ-03-2017-0048 10.1002/jbm.a.36251 10.1002/jps.2600680829 10.1016/j.ijpharm.2020.119148 10.1016/j.matpr.2019.09.156 10.1016/j.jconrel.2018.05.011 10.1016/j.jpba.2020.113257 10.1211/0022357022539 10.1007/s11095-010-0303-7 10.1016/j.xphs.2015.12.016 10.1038/s41598-019-56350-w 10.22159/ijap.2020v12i2.36812 10.3233/JAD-141791 10.1089/08942680152484199 10.1055/s-0029-1242032 10.2500/aap.2015.36.3817 10.1186/s12903-020-01362-6 10.4103/1673-5374.241458 10.1016/j.ijom.2019.03.962 10.1016/j.precisioneng.2020.12.022 10.1007/s11095-013-1157-6 10.1016/j.jconrel.2008.11.009 10.1016/j.ejps.2020.105698 10.1089/jam.2007.0638 10.1007/s00170-019-03965-y 10.5530/ijpi.2020.3.61 10.1016/j.mne.2018.12.004 10.2147/COPD.S141976 10.1016/j.ijpharm.2020.119046 10.1016/S0169-409X(97)00059-8 10.1016/S0928-0987(00)00087-7 10.1007/s11095-011-0417-6 10.1021/mp100029t 10.1016/j.apgeochem.2018.08.012 10.1016/j.ifacol.2019.10.071 10.3109/10717544.2011.644349 10.1007/s13346-020-00747-y 10.1016/j.jbiomech.2012.11.022 10.2174/1567201815666181011121750 10.1016/j.jaerosci.2007.02.002 10.1016/j.ijpharm.2018.06.058 10.1016/j.ejpb.2018.06.011 10.3390/pharmaceutics11010008 10.1016/S0378-5173(96)04817-X 10.1016/j.jconrel.2020.07.044 10.15171/apb.2019.023 10.1016/S1359-6446(02)02529-1 10.1038/s41541-020-0172-y 10.1186/s41747-019-0113-6 10.1016/B978-0-12-819712-7.00015-2 10.3390/pharmaceutics11030113 10.1016/j.addr.2008.09.008 10.1016/0378-5173(94)00238-Z 10.1371/journal.pone.0198370 10.1080/17452759.2013.778175 10.1016/j.jconrel.2012.06.014 10.1089/jamp.2013.1084 10.1186/s13068-016-0451-z 10.1016/j.jconrel.2017.09.001 10.1016/S0021-8502(02)00044-7 10.3390/ph13110356 10.1016/B978-0-12-814487-9.00007-7 10.1016/j.jaerosci.2010.11.008 10.1002/alr.21105 10.1016/j.xphs.2016.03.033 10.1016/j.jddst.2015.05.002 10.1016/j.compbiomed.2019.02.013 10.1016/j.compbiomed.2008.03.008 10.1016/j.addr.2021.01.016 10.1016/j.ijpharm.2018.08.036 10.3233/BIR-1987-24606 10.1016/j.cirp.2007.10.004 10.1016/j.jaerosci.2010.11.002 10.3390/pharmaceutics12070599 10.1007/s11517-008-0384-1 10.1080/17425247.2020.1762563 10.1208/s12249-011-9727-6 10.1016/j.ijpharm.2019.118911 10.1016/j.powtec.2020.10.061 10.1080/10826076.2019.1571508 10.1007/s13346-012-0108-9 10.1016/j.ijpharm.2019.118635 10.1016/j.ijpharm.2017.06.085 10.1016/j.msec.2019.110070 10.5530/ijpi.2020.3.51 10.3109/1061186X.2010.523787 10.1108/13552549610732034 10.1016/j.jconrel.2019.06.021 10.1016/j.brainres.2019.146503 10.1038/164799b0 10.1016/j.ijpharm.2015.12.071 10.1080/02786826.2014.931566 10.1002/jps.2600760709 10.1046/j.1365-2273.2000.00420.x 10.1517/17425247.2012.636801 10.3348/kjr.2016.17.2.182 10.1080/02652048.2018.1487473 10.1016/j.drudis.2019.10.005 10.1016/j.jconrel.2018.10.020 10.1016/j.ejpb.2019.12.014 10.1016/j.compbiomed.2017.04.018 10.1016/j.jconrel.2019.03.032 10.1089/jamp.2011.0924 10.2133/dmpk.22.206 10.1080/1061186X.2019.1574300 10.1002/jps.21939 10.1080/21645515.2016.1239668 10.1089/jamp.2012.1011 10.1016/j.ejps.2017.09.027 10.1007/978-1-4614-7978-9_5 10.1016/S1359-6446(02)02452-2 10.1002/lary.28524 10.1016/S0378-5173(00)00668-2 10.1016/j.ijpharm.2018.01.024 10.1089/jamp.2014.1205 10.1371/journal.pone.0221330 10.1111/jmi.12179 10.1080/10667857.2019.1575535 10.1080/08982104.2018.1552703 10.1007/s11095-018-2385-6 10.1016/j.xphs.2020.04.007 10.1016/j.compbiomed.2016.08.002 10.1016/j.addr.2017.09.023 10.30534/ijeter/2020/10812020 10.4155/tde-2020-0054 10.1007/s10973-017-6393-2 10.2165/00003088-200342130-00003 10.1016/j.compbiomed.2020.103600 10.1055/a-1193-4781 10.2147/IJN.S261855 10.1016/j.jddst.2021.102377 10.5599/admet.3.2.182 10.1016/j.jconrel.2006.12.014 10.1243/09544119JEIM423 10.1002/lary.20585 10.1007/s41810-020-00068-0 10.1002/cnm.2968 10.1016/j.ijpharm.2011.12.040 10.3109/08958378.2015.1066904 10.17925/USN.2020.16.1.25 10.3390/mi9030115 10.1080/10837450.2020.1740257 |
| ContentType | Journal Article |
| Copyright | 2021 Elsevier B.V. Copyright © 2021 Elsevier B.V. All rights reserved. |
| Copyright_xml | – notice: 2021 Elsevier B.V. – notice: Copyright © 2021 Elsevier B.V. All rights reserved. |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1016/j.addr.2021.113826 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology Pharmacy, Therapeutics, & Pharmacology |
| EISSN | 1872-8294 |
| ExternalDocumentID | 34119575 10_1016_j_addr_2021_113826 S0169409X21002167 |
| Genre | Journal Article Review |
| GroupedDBID | --- --K --M .~1 0R~ 1B1 1RT 1~. 1~5 23M 4.4 457 4G. 53G 5GY 5VS 7-5 71M 8P~ 9JM AABNK AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AATCM AAXUO ABFNM ABGSF ABJNI ABMAC ABUDA ABXDB ABYKQ ABZDS ACDAQ ACGFS ACIUM ACRLP ADBBV ADEZE ADMUD ADUVX AEBSH AEHWI AEKER AENEX AFKWA AFTJW AFXIZ AGHFR AGRDE AGUBO AGYEJ AHHHB AIEXJ AIKHN AITUG AJBFU AJOXV ALCLG ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC C45 CS3 DOVZS EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HMT HVGLF HX~ HZ~ IHE J1W KOM M34 M41 MO0 N9A O-L O9- OAUVE OGGZJ OVD OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SCC SDF SDG SDP SES SEW SPCBC SPT SSP SSU SSZ T5K TEORI WUQ Y6R ~G- AATTM AAXKI AAYWO AAYXX ABWVN ACRPL ACVFH ADCNI ADNMO ADVLN AEIPS AEUPX AFJKZ AFPUW AGCQF AGQPQ AGRNS AIGII AIIUN AKBMS AKRWK AKYEP ANKPU APXCP BNPGV CITATION SSH CGR CUY CVF ECM EIF NPM 7X8 |
| ID | FETCH-LOGICAL-c400t-ec4bf1983d096a98813a9b04524e1e60484e228b9118f5aab886c65fb43f0a7d3 |
| IEDL.DBID | .~1 |
| ISSN | 0169-409X 1872-8294 |
| IngestDate | Thu Jul 10 17:23:37 EDT 2025 Wed Feb 19 02:26:27 EST 2025 Tue Jul 01 03:36:06 EDT 2025 Thu Apr 24 23:07:22 EDT 2025 Fri Feb 23 02:38:07 EST 2024 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | Nasal casts Formulation properties Treatment effectiveness Administration devices Pre-formulation studies Olfactory region Nose-to-brain 3D printing |
| Language | English |
| License | Copyright © 2021 Elsevier B.V. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c400t-ec4bf1983d096a98813a9b04524e1e60484e228b9118f5aab886c65fb43f0a7d3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
| ORCID | 0000-0001-7604-0584 0000-0003-4999-8601 |
| OpenAccessLink | https://dipot.ulb.ac.be/dspace/bitstream/2013/325273/3/Review_preprint.pdf |
| PMID | 34119575 |
| PQID | 2540718765 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_2540718765 pubmed_primary_34119575 crossref_citationtrail_10_1016_j_addr_2021_113826 crossref_primary_10_1016_j_addr_2021_113826 elsevier_sciencedirect_doi_10_1016_j_addr_2021_113826 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2021-08-01 |
| PublicationDateYYYYMMDD | 2021-08-01 |
| PublicationDate_xml | – month: 08 year: 2021 text: 2021-08-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | Netherlands |
| PublicationPlace_xml | – name: Netherlands |
| PublicationTitle | Advanced drug delivery reviews |
| PublicationTitleAlternate | Adv Drug Deliv Rev |
| PublicationYear | 2021 |
| Publisher | Elsevier B.V |
| Publisher_xml | – name: Elsevier B.V |
| References | Verma, Mishra (b0140) 2016; 5 Borhade, Pathak, Sharma, Patravale (b0165) 2012; 431 Homer, Dowley, Condon, El-Jassar, Sood (b0390) 2000; 25 Wingrove, Swedrowska, Scherließ, Parry, Ramjeeawon, Taylor, Gauthier, Brown, Amiel, Zelaya, Forbes (b0125) 2019; 302 Sultan, Allaf-Akbari, Ashgriz (b0700) 2020; 4 Moinuddin, Hasan Razvi, Fazil, Mustaneer Akmal, Syed Moinuddin, Shanawaz Uddin, Shahidulla (b0015) 2019; 8 Keustermans, Huysmans, Schmelzer, Sijbers, Dirckx (b0835) 2020; 117 Popescu, Ghica, Dinu-Pîrvu, Anuța, Lupuliasa, Popa (b0575) 2020; 21 Tan, Parekh, Pandey, Siskind, Falconer (b0185) 2020; 17 Illum (b0530) 2010; 56 Patel, Chavhan, Soni, Babbar, Mathur, Mishra, Sawant (b0345) 2011; 19 Zhang, Huang, Si, Xu (b0710) 2012; 9 Bunea, Jakobsen, Engay, Bañas, Glückstad (b1065) 2019; 2 Patel, Padhye, Nagarsenker (b0170) 2012; 13 Lafforgue, Seyssiecq, Poncet, Favier (b1055) 2018; 106 Puchelle, Zahm, Quemada (b1060) 1987; 24 J.D. Ehrick, S.A. Shah, C. Shaw, V.S. Kulkarni, I. Coowanitwong, S. De, J.D. Suman, Considerations for the Development of Nasal Dosage Forms, in: 2013: pp. 99–144. https://doi.org/10.1007/978-1-4614-7978-9_5. Di, Zhang, Liu, Tong, Sun, Tang, Chen, Wu (b0500) 2021; 379 Warnken, Smyth, Davis, Weitman, Kuhn, Williams (b0120) 2018; 15 Frank, Kimbell, Pawar, Rhee (b0705) 2012; 146 Kotz, Risch, Helmer, Rapp (b0920) 2018; 9 Jassim, Al-akkam (b0085) 2018; 10 Xi, Wang, Nevorski, White, Zhou (b0725) 2017; 30 Altundag, Temirbekov, Haci, Yildirim, Cayonu (b0975) 2021; 131 Cometa, Bonifacio, Trapani, Di Gioia, Dazzi, De Giglio, Trapani (b0270) 2020; 185 Huber, Streng, Tan (b0250) 1979; 68 Olivier, Djilani, Fahmy, Couet (b0385) 2001; 213 Goldstein, Soroka, Frušić-Zlotkin, Popov, Kohen (b0510) 2014; 256 El Moumen, Tarfaoui, Lafdi (b0880) 2019; 104 Bansil, Turner (b0960) 2018; 124 Salade, Wauthoz, Vermeersch, Amighi, Goole (b0155) 2018; 129 Chen, Kiaee, Martin, Finlay (b0820) 2020; 582 Ligon, Liska, Stampfl, Gurr, Mülhaupt (b0890) 2017; 117 Yusuf, Kett (b0620) 2017; 13 Ghadiri, Young, Traini (b0075) 2019; 11 Goyanes, Det-Amornrat, Wang, Basit, Gaisford (b0855) 2016; 234 Xi, Yuan, Zhang, Nevorski, Wang, Zhou (b0130) 2016; 33 Cunha, Costa, Loureiro, Alves, Peixoto, Forbes, Lobo, Silva (b0650) 2020; 12 Sawant, Donovan (b0110) 2018; 35 Illum (b0180) 2002; 7 Moraga-Espinoza, Warnken, Moore, Williams, Smyth (b0440) 2018; 548 Singh, Gothwal, Rani, Rana, Sharma, Yadav, Gupta (b0280) 2019; 4 Sartoretti, Mannil, Biendl, Froehlich, Alkadhi, Zadory (b1005) 2019; 3 Belgamwar, Khan, Yeole (b0275) 2019; 52 Mukai, Mukai, Santos-Junior, Shibli, Faveri, Giro (b0915) 2021; 21 Agrawal, Saraf, Saraf, Dubey, Puri, Gupta, Kesharwani, Ravichandiran, Kumar, Naidu, Murty, Ajazuddin (b0625) 2020; 327 Bhattamisra, Shak, Xi, Safian, Choudhury, Lim, Shahzad, Alhakamy, Anwer, Radhakrishnan, Md (b0360) 2020; 579 Gungor (b0825) 2013; 3 FDA, Inactive Ingredients Database Download, (2021). https://www.fda.gov/drugs/drug-approvals-and-databases/inactive-ingredients-database-download (accessed February 16, 2021). Gopinath, Naidu (b0150) 2011; 2 Hatz, Msallem, Aghlmandi, Brantner, Thieringer (b0935) 2020; 49 Misik, Maly, Cejpek, Lizal (b0730) 2020; 328 Cheng, Holmes, Gao, Guilmette, Li, Surakitbanharn, Rowlings (b0790) 2001; 14 Kiaee, Wachtel, Noga, Martin, Finlay (b0770) 2019; 107 Ranade (b0160) 2010 Arora, Sharma, Garg (b0195) 2002; 7 Lafforgue, Seyssiecq, Poncet, Favier (b1040) 2018; 106 Khan, Liu, Khan, Zhai (b0745) 2017; 268 S.T. Charlton, S.S. Davis, L. Illum, Evaluation of bioadhesive polymers as delivery systems for nose to brain delivery : In vitro characterisation studies, 118 (2007) 225–234. https://doi.org/10.1016/j.jconrel.2006.12.014. Kundoor, Dalby (b1020) 2011; 28 Migliore, Vyas, Campbell, Amiji, Waszczak (b0475) 2010; 99 Schroeter, Tewksbury, Wong, Kimbell (b0055) 2015; 28 Prajapati, Patel (b0265) 2021 Akel, Ismail, Csóka, Tan, Parekh, Pandey, Siskind, Falconer, Musumeci, Bonaccorso, Puglisi, Akel, Ismail, Csóka, Patel, Patel, Bhatt, Patel, Gaikwad, Delivery, Alhakamy, Aldawsari, Asfour (b0640) 2020; 148 Quatela, Pearson (b0840) 2009; 25 Kulkarni, Bari, Surana, Pardeshi (b0405) 2016; 31 Rassu, Soddu, Cossu, Gavini, Giunchedi, Dalpiaz (b0545) 2016; 32 Keyhan shokouh, Faghihi, Darabi, Mirmoeini, Vatanara (b0505) 2021; 62 Kaye, Purewal, Alpar (b0780) 2009; 135 Kim, Lee, Kim, Yang, Kim, Kyung, Kim, Choi, Kim, Ha, Kwon, Kim (b0870) 2016; 17 Erokhin, Gordeev, Ananikov (b0895) 2019; 9 Takeuchi, Imamura, Ji, Tsukita, Enami, Takao, Miyakawa, Hasegawa, Sahara, Iwata, Inoue, Hara, Tabira, Ono, Trojanowski, Lee, Takahashi, Suhara, Higuchi, Inoue (b0480) 2020; 5 Qureshi, Aqil, Imam, Ahad, Sultana (b0295) 2018; 16 Foo, Cheng, Su, Donovan (b0765) 2007; 20 Strege, Huang, Risley (b0590) 2019; 42 Xiong, Zhan, Zuo, Li, Rong, Xu (b0815) 2008; 46 Johnson, Hanson, Frey (b0060) 2010; 7 Forbes, Bommer, Goole, Hellfritzsch, De Kruijf, Lambert, Caivano, Regard, Schiaretti, Trenkel, Vecellio, Williams, Sonvico, Scherließ (b0045) 2020; 17 Sosnowski, Rapiejko, Sova, Dobrowolska (b0785) 2020; 574 Masjedi, Azadi, Heidari, Mohammadi-Samani (b0305) 2020; 72 Wang, Kirwan, Abraham, Staats, Hickey (b0320) 2012; 101 Calignano, Manfredi, Ambrosio, Biamino, Lombardi, Atzeni, Salmi, Minetola, Iuliano, Fino (b0850) 2017; 105 von Halling Laier, Gibson, van de Weert, Boyd, Rades, Boisen, Hook, Nielsen (b0340) 2018; 550 Escada, Lima, Da Silva (b0540) 2009; 266 Schroeter, Garcia, Kimbell (b0965) 2011; 42 Illum, Jordan, Lewis (b0600) 2012; 162 Le Corre (b0095) 2001; 15 Dua, Zia, Needham (b0380) 1997; 147 Pilcer, Amighi (b0485) 2010; 392 Ledeti, Bolintineanu, Vlase, Circioban, Ledeti, Vlase, Suta, Caunii, Murariu (b0300) 2017; 130 Preston, Randolph (b0330) 2021 Alexander, Agrawal, Uddin, Siddique, Shehata, Shaker (b0090) 2019; 14 Gordeev, Galushko, Ananikov (b0900) 2018; 13 Muwaffak, Goyanes, Clark, Basit, Hilton, Gaisford (b0990) 2017; 527 Padalkar, Madgulkar, Bhalekar (b0660) 2020; 10 Furubayashi, Inoue, Kamaguchi, Higashi, Sakane (b0430) 2007; 22 Md, Mustafa, Baboota, Ali (b0215) 2015; 41 Tiozzo Fasiolo, Manniello, Bortolotti, Buttini, Rossi, Sonvico, Colombo, Valsami, Colombo, Russo (b0495) 2019; 27 Calmet, Inthavong, Eguzkitza, Lehmkuhl, Houzeaux, Vázquez (b0455) 2019; 14 Claxton, Baker, Hanson, Trittschuh, Cholerton, Morgan, Callaghan, Arbuckle, Behl, Craft (b0735) 2015; 44 Hosny (b0670) 2020; 15 Shah, Dickens, Ward, Banaszek, George, Horodnik (b0115) 2014; 27 Chandra (b0940) 2020; 8 Ngan, O’Connell, Blanchard, Boyd-Moss, Williams, Bourke, Quigley, McKelvie, Kapsa, Choong (b0950) 2019; 14 Gayer, Ritter, Bullemer, Grom, Jauer, Meiners, Pfister, Reinauer, Vučak, Wissenbach, Fischer, Poprawe, Schleifenbaum (b0945) 2019; 101 Wang, Yang, Liu, Tao, Li, Wu, Gui (b0400) 2020; 577 Djupesland (b0750) 2013; 3 Wang, Zuo, Cheung, Leung (b0635) 2019; 559 Leong, Chen, Lee, Wang (b0515) 2010; 48 Hoekman, Ray, Aurora, Shrewsbury (b0740) 2020; 16 Illum (b0065) 2000; 11 Kabiri, Bolourian, Dehghan, Tafaghodi (b0560) 2020; 24 Manta, Papakyriakopoulou, Chountoulesi, Diamantis, Spaneas, Vakali, Naziris, Chatziathanasiadou, Andreadelis, Moschovou, Athanasiadou, Dallas, Rekkas, Demetzos, Colombo, Banella, Javornik, Plavec, Mavromoustakos, Tzakos, Valsami (b0580) 2020; 17 Inthavong, Tian, Tu, Yang, Xue (b0680) 2008; 38 Kulkarni, Vanjari, Sancheti, Belgamwar, Surana, Pardeshi (b0030) 2015; 23 Agrawal, Saraf, Saraf, Antimisiaris, Chougule, Shoyele, Alexander (b0035) 2018; 281 Rygg, Hindle, Longest (b0245) 2016; 105 Pujara, Shao, Duncan, Mitra (b0375) 1995; 114 Chen, Lee, Hin Chong, Wang (b0100) 2009; 119 Keeler, Patki, Woodard, Frank-Ito (b0830) 2016; 29 Inthavong, Ge, Se, Yang, Tu (b0685) 2011; 42 Shah, Berger, McDermott, Gupta, Monteith, Connor, Lin (b0460) 2015; 36 Alexander, Saraf (b0040) 2018; 13 Yang, Li, Li, Zhang, Gao, Sun, Yin, Zheng (b0585) 2018; 44 Xiang, Long, Yang, Zheng, Cui, Ci, Lv, Li, Zhang (b0655) 2020; 1726 Fransén, Bredenberg, Björk (b0610) 2009; 26 Pires, Santos, Rodrigues, Alves, Santos (b0435) 2021; 592 Gross, Zhao, Mascarenhas, Wen (b1070) 2016; 9 Yarragudi, Kumar, Jain, Tawhai, Rizwan (b0050) 2020; 33 McMartin, Hutchinson, Hyde, Peters (b0240) 1987; 76 Arisoy, Sayiner, Comoglu, Onal, Atalay, Pehlivanoglu (b0310) 2020; 25 Vaezi, Chianrabutra, Mellor, Yang (b0905) 2013; 8 Hussein, Omer, Ismael, Albed Alhnan, Elhissi, Ahmed (b0260) 2020; 25 Jüptner, Scherließ (b0520) 2020; 12 Kim, Na, Kim, Chung (b0810) 2013; 46 Wang, Zuo, Cheung, Leung, Aderibigbe, Wang, Zuo, Cheung, Leung (b0630) 2019; 559 Kim, Lin, Tseng (b0865) 2018; 24 Löffler, Koch (b0875) 2019; 52 Sara Assadpour, Akhtari (b0365) 2021; 8 Jin, Kim, Kim, Kim (b0955) 2019; 28 Kelly, Asgharian, Kimbell, Wong (b0910) 2004; 38 Geng, Bidanda (b0885) 2021; 69 Lin, Liu, He, Shin, Moon, Yang, Huang (b0230) 2016; 6 Lin, Chen, Li, Chen, Lee, Huang, Chuang, Harn, Yang, Lin, Tai, Chiou (b0420) 2020; 21 Chen, Katz, Pichelin, Zhu, Caillibotte, Noga, Finlay, Martin (b0970) 2017; 12 Pu, Goodey, Fang, Jacob (b0445) 2014; 48 Khaled, Alexander, Wildman, Wallace, Sharpe, Yoo, Roberts (b0995) 2018; 538 Kim, Sung, Kim, Kong, Kim, Hahn (b0410) 2019; 307 Battaglia, Panciani, Muntoni, Capucchio, Biasibetti, De Bonis, Mioletti, Fontanella, Swaminathan (b0645) 2018; 15 V. Pandey, A. Gadeval, S. Asati, P. Jain, N. Jain, R.K. Roy, M. Tekade, V. Soni, R.K. Tekade, Formulation strategies for nose-to-brain delivery of therapeutic molecules, Elsevier Inc., 2019. https://doi.org/10.1016/B978-0-12-814487-9.00007-7. García Esteban, Cózar-Bernal, Rabasco Álvarez, González-Rodríguez (b0335) 2018; 35 Djupesland, Skretting (b0760) 2012; 25 Ç.Y.A. et C.J. M., Fluid mechanics: fundamentals and applications, 3e edition, 2014, New York, n.d. H.W. C., Aerosol technology: properties, behavior, and measurement of airborne particles, 2e edition, 1999, New York, n.d. Giuliani, Balducci, Zironi, Colombo, Bortolotti, Lorenzini, Galligioni, Pagliuca, Scagliarini, Calzà, Sonvico (b0210) 2018; 25 Patil, Pawara, Gudewar, Tekade (b0370) 2019; 29 Le Guellec, Le Pennec, Gatier, Leclerc, Cabrera, Pourchez, Diot, Reychler, Pitance, Durand, Jamar, Vecellio (b1000) 2014; 31 Zhao, Kim, Craig, Palmer (b0930) 2020 Vasa, Buckner, Cavanaugh, Wildfo Sullivan (10.1016/j.addr.2021.113826_b0720) 2011 Le Corre (10.1016/j.addr.2021.113826_b0095) 2001; 15 Rajarajan (10.1016/j.addr.2021.113826_b0285) 2020; 10 Illum (10.1016/j.addr.2021.113826_b0600) 2012; 162 Pilcer (10.1016/j.addr.2021.113826_b0485) 2010; 392 Chen (10.1016/j.addr.2021.113826_b0820) 2020; 582 Gross (10.1016/j.addr.2021.113826_b1070) 2016; 9 Xi (10.1016/j.addr.2021.113826_b0130) 2016; 33 Prajapati (10.1016/j.addr.2021.113826_b0265) 2021 Borhade (10.1016/j.addr.2021.113826_b0165) 2012; 431 Le Guellec (10.1016/j.addr.2021.113826_b0135) 2020 Hussain (10.1016/j.addr.2021.113826_b0350) 2016; 8 Ladel (10.1016/j.addr.2021.113826_b0535) 2019; 11 Fransén (10.1016/j.addr.2021.113826_b0610) 2009; 26 Ledeti (10.1016/j.addr.2021.113826_b0300) 2017; 130 Zham (10.1016/j.addr.2021.113826_b1050) 1991; 4 Moraga-Espinoza (10.1016/j.addr.2021.113826_b0440) 2018; 548 Masjedi (10.1016/j.addr.2021.113826_b0305) 2020; 72 Lafforgue (10.1016/j.addr.2021.113826_b1040) 2018; 106 Calignano (10.1016/j.addr.2021.113826_b0850) 2017; 105 Akel (10.1016/j.addr.2021.113826_b0640) 2020; 148 Cone (10.1016/j.addr.2021.113826_b1045) 2009; 61 Kabiri (10.1016/j.addr.2021.113826_b0560) 2020; 24 Agrawal (10.1016/j.addr.2021.113826_b0035) 2018; 281 Ranade (10.1016/j.addr.2021.113826_b0160) 2010 Sawant (10.1016/j.addr.2021.113826_b0110) 2018; 35 Keustermans (10.1016/j.addr.2021.113826_b0835) 2020; 117 Salem (10.1016/j.addr.2021.113826_b0220) 2020; 109 Keeler (10.1016/j.addr.2021.113826_b0830) 2016; 29 Khalid (10.1016/j.addr.2021.113826_b0980) 2020; 20 Qureshi (10.1016/j.addr.2021.113826_b0295) 2018; 16 Vaezi (10.1016/j.addr.2021.113826_b0905) 2013; 8 Kushwaha (10.1016/j.addr.2021.113826_b0190) 2011; 1 Shete (10.1016/j.addr.2021.113826_b0175) 2013; 454 Khan (10.1016/j.addr.2021.113826_b0745) 2017; 268 de Oliveira Junior (10.1016/j.addr.2021.113826_b0550) 2019; 36 Wang (10.1016/j.addr.2021.113826_b0400) 2020; 577 Goldstein (10.1016/j.addr.2021.113826_b0510) 2014; 256 Hosny (10.1016/j.addr.2021.113826_b0670) 2020; 15 Escada (10.1016/j.addr.2021.113826_b0540) 2009; 266 Keyhan shokouh (10.1016/j.addr.2021.113826_b0505) 2021; 62 Kundoor (10.1016/j.addr.2021.113826_b1020) 2011; 28 Trows (10.1016/j.addr.2021.113826_b0775) 2016; 292 Ahmed (10.1016/j.addr.2021.113826_b0675) 2020; 13 Shah (10.1016/j.addr.2021.113826_b0115) 2014; 27 Liu (10.1016/j.addr.2021.113826_b0200) 2011; 28 Johnson (10.1016/j.addr.2021.113826_b0060) 2010; 7 10.1016/j.addr.2021.113826_b0425 Bhattamisra (10.1016/j.addr.2021.113826_b0360) 2020; 579 Foo (10.1016/j.addr.2021.113826_b0765) 2007; 20 Kim (10.1016/j.addr.2021.113826_b1025) 2017; 86 Lin (10.1016/j.addr.2021.113826_b0420) 2020; 21 Moinuddin (10.1016/j.addr.2021.113826_b0015) 2019; 8 Zhao (10.1016/j.addr.2021.113826_b0930) 2020 Sultan (10.1016/j.addr.2021.113826_b0700) 2020; 4 Yarragudi (10.1016/j.addr.2021.113826_b0050) 2020; 33 Wang (10.1016/j.addr.2021.113826_b0320) 2012; 101 Sabir (10.1016/j.addr.2021.113826_b0020) 2020; 25 Mostafa (10.1016/j.addr.2021.113826_b0415) 2020; 12 Kumar (10.1016/j.addr.2021.113826_b0080) 2017; 5 Pu (10.1016/j.addr.2021.113826_b0445) 2014; 48 Pires (10.1016/j.addr.2021.113826_b0435) 2021; 592 Yusuf (10.1016/j.addr.2021.113826_b0620) 2017; 13 Lungare (10.1016/j.addr.2021.113826_b0805) 2016; 105 Alexander (10.1016/j.addr.2021.113826_b0090) 2019; 14 Kletetschka (10.1016/j.addr.2021.113826_b0925) 2018; 98 Kulkarni (10.1016/j.addr.2021.113826_b0405) 2016; 31 Lin (10.1016/j.addr.2021.113826_b0230) 2016; 6 Matarazzo (10.1016/j.addr.2021.113826_b0290) 2021; 159 Popescu (10.1016/j.addr.2021.113826_b0575) 2020; 21 Chen (10.1016/j.addr.2021.113826_b0100) 2009; 119 Xiang (10.1016/j.addr.2021.113826_b0655) 2020; 1726 Frank (10.1016/j.addr.2021.113826_b0705) 2012; 146 Kim (10.1016/j.addr.2021.113826_b0865) 2018; 24 Preston (10.1016/j.addr.2021.113826_b0330) 2021 Pandey (10.1016/j.addr.2021.113826_b0555) 2020; 70 Khaled (10.1016/j.addr.2021.113826_b0995) 2018; 538 Lafforgue (10.1016/j.addr.2021.113826_b1055) 2018; 106 Davis (10.1016/j.addr.2021.113826_b0595) 2003; 42 Pujara (10.1016/j.addr.2021.113826_b0375) 1995; 114 Djupesland (10.1016/j.addr.2021.113826_b1030) 2020; 11 Yan (10.1016/j.addr.2021.113826_b0235) 2013; 21 Jassim (10.1016/j.addr.2021.113826_b0085) 2018; 10 Garcia (10.1016/j.addr.2021.113826_b0615) 2015; 27 Takeuchi (10.1016/j.addr.2021.113826_b0480) 2020; 5 Liu (10.1016/j.addr.2021.113826_b0845) 2009; 106 Tiozzo Fasiolo (10.1016/j.addr.2021.113826_b0605) 2018; 113 Goole (10.1016/j.addr.2021.113826_b0860) 2016; 499 Löffler (10.1016/j.addr.2021.113826_b0875) 2019; 52 Patel (10.1016/j.addr.2021.113826_b0345) 2011; 19 Huber (10.1016/j.addr.2021.113826_b0250) 1979; 68 Gopinath (10.1016/j.addr.2021.113826_b0150) 2011; 2 Steipel (10.1016/j.addr.2021.113826_b0695) 2019; 105 Bahadur (10.1016/j.addr.2021.113826_b0205) 2012; 9 Md (10.1016/j.addr.2021.113826_b0215) 2015; 41 Clark (10.1016/j.addr.2021.113826_b0985) 2017; 529 Djupesland (10.1016/j.addr.2021.113826_b0760) 2012; 25 Illum (10.1016/j.addr.2021.113826_b0530) 2010; 56 Dhaliwal (10.1016/j.addr.2021.113826_b0665) 2020; 17 Puchelle (10.1016/j.addr.2021.113826_b1060) 1987; 24 Quatela (10.1016/j.addr.2021.113826_b0840) 2009; 25 Samia (10.1016/j.addr.2021.113826_b0470) 2012; 19 Ngan (10.1016/j.addr.2021.113826_b0950) 2019; 14 Grunberg (10.1016/j.addr.2021.113826_b1035) 1949; 164 Xiong (10.1016/j.addr.2021.113826_b0815) 2008; 46 Inthavong (10.1016/j.addr.2021.113826_b0680) 2008; 38 Patil (10.1016/j.addr.2021.113826_b0370) 2019; 29 El Moumen (10.1016/j.addr.2021.113826_b0880) 2019; 104 Geng (10.1016/j.addr.2021.113826_b0885) 2021; 69 10.1016/j.addr.2021.113826_b0715 Goyanes (10.1016/j.addr.2021.113826_b0855) 2016; 234 Erokhin (10.1016/j.addr.2021.113826_b0895) 2019; 9 Rassu (10.1016/j.addr.2021.113826_b0545) 2016; 32 Arisoy (10.1016/j.addr.2021.113826_b0310) 2020; 25 Djupesland (10.1016/j.addr.2021.113826_b0750) 2013; 3 Sosnowski (10.1016/j.addr.2021.113826_b0785) 2020; 574 Hatz (10.1016/j.addr.2021.113826_b0935) 2020; 49 10.1016/j.addr.2021.113826_b1010 Strege (10.1016/j.addr.2021.113826_b0590) 2019; 42 Shi (10.1016/j.addr.2021.113826_b0450) 2007; 38 Butcher (10.1016/j.addr.2021.113826_b0225) 2015; 3 Dua (10.1016/j.addr.2021.113826_b0380) 1997; 147 Kim (10.1016/j.addr.2021.113826_b0870) 2016; 17 Hughes (10.1016/j.addr.2021.113826_b0105) 2008; 222 Kelly (10.1016/j.addr.2021.113826_b0910) 2004; 38 Marttin (10.1016/j.addr.2021.113826_b0525) 1998; 29 Khalili (10.1016/j.addr.2021.113826_b0755) 2013; 3 Xi (10.1016/j.addr.2021.113826_b0725) 2017; 30 Schroeter (10.1016/j.addr.2021.113826_b0055) 2015; 28 Bansil (10.1016/j.addr.2021.113826_b0960) 2018; 124 Tong (10.1016/j.addr.2021.113826_b0690) 2016; 77 Vilegave (10.1016/j.addr.2021.113826_b0145) 2013; 1 Bunea (10.1016/j.addr.2021.113826_b1065) 2019; 2 Manta (10.1016/j.addr.2021.113826_b0580) 2020; 17 Yang (10.1016/j.addr.2021.113826_b0585) 2018; 44 Inthavong (10.1016/j.addr.2021.113826_b0685) 2011; 42 Mukai (10.1016/j.addr.2021.113826_b0915) 2021; 21 Kruth (10.1016/j.addr.2021.113826_b0800) 2007; 56 Singh (10.1016/j.addr.2021.113826_b0280) 2019; 4 Wingrove (10.1016/j.addr.2021.113826_b0125) 2019; 302 Jüptner (10.1016/j.addr.2021.113826_b0520) 2020; 12 10.1016/j.addr.2021.113826_b0255 Leong (10.1016/j.addr.2021.113826_b0515) 2010; 48 McMartin (10.1016/j.addr.2021.113826_b0240) 1987; 76 Migliore (10.1016/j.addr.2021.113826_b0475) 2010; 99 Cunha (10.1016/j.addr.2021.113826_b0650) 2020; 12 Cheng (10.1016/j.addr.2021.113826_b0790) 2001; 14 Upadhaya (10.1016/j.addr.2021.113826_b0025) 2020; 10 Agarwala (10.1016/j.addr.2021.113826_b0795) 1996; 2 Misik (10.1016/j.addr.2021.113826_b0730) 2020; 328 Wang (10.1016/j.addr.2021.113826_b0635) 2019; 559 Calmet (10.1016/j.addr.2021.113826_b0455) 2019; 14 Garg (10.1016/j.addr.2021.113826_b0565) 2019; 9 Illum (10.1016/j.addr.2021.113826_b0065) 2000; 11 Vasa (10.1016/j.addr.2021.113826_b0315) 2017; 18 Gordeev (10.1016/j.addr.2021.113826_b0900) 2018; 13 Schroeter (10.1016/j.addr.2021.113826_b0965) 2011; 42 10.1016/j.addr.2021.113826_b0395 Olivier (10.1016/j.addr.2021.113826_b0385) 2001; 213 García Esteban (10.1016/j.addr.2021.113826_b0335) 2018; 35 Hussein (10.1016/j.addr.2021.113826_b0260) 2020; 25 Forbes (10.1016/j.addr.2021.113826_b0045) 2020; 17 Furubayashi (10.1016/j.addr.2021.113826_b0430) 2007; 22 Padalkar (10.1016/j.addr.2021.113826_b0660) 2020; 10 Martins (10.1016/j.addr.2021.113826_b0070) 2019; 570 Kiaee (10.1016/j.addr.2021.113826_b0465) 2018; 34 Kaye (10.1016/j.addr.2021.113826_b0780) 2009; 135 Patel (10.1016/j.addr.2021.113826_b0170) 2012; 13 Cometa (10.1016/j.addr.2021.113826_b0270) 2020; 185 Ligon (10.1016/j.addr.2021.113826_b0890) 2017; 117 Gayer (10.1016/j.addr.2021.113826_b0945) 2019; 101 Claxton (10.1016/j.addr.2021.113826_b0735) 2015; 44 Altundag (10.1016/j.addr.2021.113826_b0975) 2021; 131 Sartoretti (10.1016/j.addr.2021.113826_b1005) 2019; 3 Kulkarni (10.1016/j.addr.2021.113826_b0030) 2015; 23 Belgamwar (10.1016/j.addr.2021.113826_b0275) 2019; 52 Chandra (10.1016/j.addr.2021.113826_b0940) 2020; 8 Verma (10.1016/j.addr.2021.113826_b0140) 2016; 5 Jin (10.1016/j.addr.2021.113826_b0955) 2019; 28 10.1016/j.addr.2021.113826_b0005 Tiozzo Fasiolo (10.1016/j.addr.2021.113826_b0495) 2019; 27 Kotz (10.1016/j.addr.2021.113826_b0920) 2018; 9 10.1016/j.addr.2021.113826_b0490 Kiaee (10.1016/j.addr.2021.113826_b0770) 2019; 107 10.1016/j.addr.2021.113826_b0010 Ghadiri (10.1016/j.addr.2021.113826_b0075) 2019; 11 Chen (10.1016/j.addr.2021.113826_b0970) 2017; 12 Keshari (10.1016/j.addr.2021.113826_b0355) 2019; 34 Shah (10.1016/j.addr.2021.113826_b0460) 2015; 36 Agrawal (10.1016/j.addr.2021.113826_b0625) 2020; 327 Gungor (10.1016/j.addr.2021.113826_b0825) 2013; 3 Le Guellec (10.1016/j.addr.2021.113826_b1000) 2014; 31 Rassu (10.1016/j.addr.2021.113826_b0570) 2018; 10 Wang (10.1016/j.addr.2021.113826_b0630) 2019; 559 Battaglia (10.1016/j.addr.2021.113826_b0645) 2018; 15 Warnken (10.1016/j.addr.2021.113826_b0120) 2018; 15 Muwaffak (10.1016/j.addr.2021.113826_b0990) 2017; 527 Tan (10.1016/j.addr.2021.113826_b0185) 2020; 17 Alexander (10.1016/j.addr.2021.113826_b0040) 2018; 13 Häußermann (10.1016/j.addr.2021.113826_b1015) 2002; 33 von Halling Laier (10.1016/j.addr.2021.113826_b0340) 20 |
| References_xml | – volume: 256 start-page: 237 year: 2014 end-page: 247 ident: b0510 article-title: High resolution SEM imaging of gold nanoparticles in cells and tissues publication-title: J. Microsc. – volume: 3 start-page: 32 year: 2019 ident: b1005 article-title: In vitro qualitative and quantitative CT assessment of iodinated aerosol nasal deposition using a 3D-printed nasal replica publication-title: Eur. Radiol. Exp. – volume: 268 start-page: 364 year: 2017 end-page: 389 ident: b0745 article-title: Progress in brain targeting drug delivery system by nasal route publication-title: J. Control. Release. – volume: 22 start-page: 206 year: 2007 end-page: 211 ident: b0430 article-title: Influence of formulation viscosity on drug absorption following nasal application in rats publication-title: Drug Metab. Pharmacokinet. – volume: 38 start-page: 398 year: 2007 end-page: 419 ident: b0450 article-title: Modeling of inertial particle transport and deposition in human nasal cavities with wall roughness publication-title: J. Aerosol Sci. – volume: 41 start-page: 1922 year: 2015 end-page: 1934 ident: b0215 article-title: Nanoneurotherapeutics approach intended for direct nose to brain delivery publication-title: Drug Dev. Ind. Pharm. – volume: 559 start-page: 86 year: 2019 end-page: 101 ident: b0630 article-title: Updates on thermosensitive hydrogel for nasal, ocular and cutaneous delivery publication-title: Pharmaceutics. – volume: 38 start-page: 713 year: 2008 end-page: 726 ident: b0680 article-title: Optimising nasal spray parameters for efficient drug delivery using computational fluid dynamics publication-title: Comput. Biol. Med. – volume: 33 start-page: 923 year: 2002 end-page: 933 ident: b1015 article-title: The influence of breathing patterns on particle deposition in a nasal replicate cast publication-title: J. Aerosol Sci. – volume: 36 start-page: 48 year: 2015 end-page: 57 ident: b0460 article-title: Regional deposition of mometasone furoate nasal spray suspension in humans publication-title: Allergy Asthma Proc. – volume: 86 start-page: 18 year: 2017 end-page: 30 ident: b1025 article-title: Numerical study on the air conditioning characteristics of the human nasal cavity publication-title: Comput. Biol. Med. – year: 2011 ident: b0720 article-title: Novel advances in rapid manufacturing, deployment, and delivery of intranasally administered drugs and biologics publication-title: ONdrugDelivery. – volume: 20 start-page: 408 year: 2020 end-page: 413 ident: b0980 article-title: Material response characterization of three poly jet printed materials used in a high fidelity human infant skull publication-title: Mater. Today Proc. – volume: 135 start-page: 127 year: 2009 end-page: 135 ident: b0780 article-title: Development and testing of particulate formulations for the nasal delivery of antibodies publication-title: J. Control. Release. – volume: 14 year: 2019 ident: b0455 article-title: Nasal sprayed particle deposition in a human nasal cavity under different inhalation conditions publication-title: PLoS ONE – volume: 25 start-page: 376 year: 2018 end-page: 387 ident: b0210 article-title: In vivo nose-to-brain delivery of the hydrophilic antiviral ribavirin by microparticle agglomerates publication-title: Drug Deliv. – volume: 25 start-page: 280 year: 2012 end-page: 289 ident: b0760 article-title: Nasal deposition and clearance in man: Comparison of a bidirectional powder device and a traditional liquid spray pump publication-title: J. Aerosol Med. Pulm. Drug Deliv. – volume: 109 start-page: 2237 year: 2020 end-page: 2251 ident: b0220 article-title: Coated Lipidic Nanoparticles as a New Strategy for Enhancing Nose-to-Brain Delivery of a Hydrophilic Drug Molecule publication-title: J. Pharm. Sci. – volume: 13 start-page: 125 year: 2012 end-page: 133 ident: b0170 article-title: Duloxetine HCl lipid nanoparticles: Preparation, characterization, and dosage form design publication-title: AAPS PharmSciTech. – volume: 27 start-page: 394 year: 2015 end-page: 403 ident: b0615 article-title: Olfactory deposition of inhaled nanoparticles in humans publication-title: Inhal. Toxicol. – volume: 17 start-page: 4241 year: 2020 end-page: 4255 ident: b0580 article-title: Preparation and Biophysical Characterization of Quercetin Inclusion Complexes with β-Cyclodextrin Derivatives to be Formulated as Possible Nose-to-Brain Quercetin Delivery Systems publication-title: Mol. Pharm. – volume: 21 start-page: 435 year: 2013 end-page: 441 ident: b0235 article-title: Cell-penetrating peptide-modified PLGA nanoparticles for enhanced nose-to-brain macromolecular delivery publication-title: Macromol. Res. – year: 2020 ident: b0135 article-title: In vitro – in vivo correlation of intranasal drug deposition publication-title: Adv. Drug Deliv. Rev. – volume: 4 start-page: 210 year: 2020 end-page: 218 ident: b0700 article-title: Effects of a Coflowing Air on the Characteristics of an Electrospray publication-title: Aerosol Sci. Eng. – volume: 25 start-page: 735 year: 2020 end-page: 747 ident: b0310 article-title: In vitro and in vivo evaluation of levodopa-loaded nanoparticles for nose to brain delivery publication-title: Pharm. Dev. Technol. – volume: 17 start-page: 1996 year: 2020 end-page: 2005 ident: b0665 article-title: Intranasal Delivery and Transfection of mRNA Therapeutics in the Brain Using Cationic Liposomes publication-title: Mol. Pharm. – volume: 38 start-page: 1072 year: 2004 end-page: 1079 ident: b0910 article-title: Particle Deposition in Human Nasal Airway Replicas Manufactured by Different Methods. Part I: Inertial Regime Particles publication-title: Aerosol Sci. Technol. – volume: 30 start-page: 118 year: 2017 end-page: 131 ident: b0725 article-title: Nasal and Olfactory Deposition with Normal and Bidirectional Intranasal Delivery Techniques. In Vitro Tests and Numerical Simulations, J. Aerosol Med. Pulm publication-title: Drug Deliv. – volume: 527 start-page: 161 year: 2017 end-page: 170 ident: b0990 article-title: Patient-specific 3D scanned and 3D printed antimicrobial polycaprolactone wound dressings publication-title: Int. J. Pharm. – volume: 10 start-page: 279 year: 2020 end-page: 285 ident: b0285 article-title: Design and Development of Chitosan Beta-cyclodextrin based Nasal Mucoadhesive Microspheres of Clarithromycin publication-title: Int. J. Pharm. Investig. – volume: 529 start-page: 523 year: 2017 end-page: 530 ident: b0985 article-title: 3D printing of tablets using inkjet with UV photoinitiation publication-title: Int. J. Pharm. – volume: 107 start-page: 206 year: 2019 end-page: 217 ident: b0770 article-title: An idealized geometry that mimics average nasal spray deposition in adults: A computational study publication-title: Comput. Biol. Med. – volume: 9 start-page: 195 year: 2019 end-page: 204 ident: b0565 article-title: Current Advances in Chitosan Nanoparticles Based Drug Delivery and Targeting publication-title: Adv. Pharm. Bull. – volume: 11 start-page: 485 year: 2020 end-page: 495 ident: b1030 article-title: Role of nasal casts for in vitro evaluation of nasal drug delivery and quantitative evaluation of various nasal casts publication-title: Ther. Deliv. – volume: 148 start-page: 38 year: 2020 end-page: 53 ident: b0640 article-title: Progress and perspectives of brain-targeting lipid-based nanosystems via the nasal route in Alzheimer’s disease publication-title: Eur. J. Pharm. Biopharm. – volume: 14 start-page: 5895 year: 2019 end-page: 5909 ident: b0090 article-title: S. Ata Ur Rahman, M.I.M. Abdul, M.A. Shaker, Recent expansions of novel strategies towards the drug targeting into the brain publication-title: Int. J. Nanomedicine. – volume: 15 start-page: 5113 year: 2020 end-page: 5129 ident: b0670 article-title: Nanosized cubosomal thermogelling dispersion loaded with saquinavir mesylate to improve its bioavailability: Preparation, optimization, in vitro and in vivo evaluation publication-title: Int. J. Nanomedicine. – volume: 13 start-page: 2102 year: 2018 end-page: 2104 ident: b0040 article-title: Nose-to-brain drug delivery approach: A key to easily accessing the brain for the treatment of Alzheimer’s disease publication-title: Neural Regen. Res. – volume: 34 year: 2018 ident: b0465 article-title: Regional deposition of nasal sprays in adults: A wide ranging computational study publication-title: Int. j. Numer. Method. Biomed. Eng. – volume: 117 year: 2020 ident: b0835 article-title: The effect of nasal shape on the thermal conditioning of inhaled air: Using clinical tomographic data to build a large-scale statistical shape model publication-title: Comput. Biol. Med. – volume: 28 start-page: 20 year: 2015 end-page: 29 ident: b0055 article-title: Experimental Measurements and Computational Predictions of Regional Particle Deposition in a Sectional Nasal Model publication-title: J. Aerosol Med. Pulm. Drug Deliv. – volume: 44 start-page: 897 year: 2015 end-page: 906 ident: b0735 article-title: Long-Acting Intranasal Insulin Detemir Improves Cognition for Adults with Mild Cognitive Impairment or Early-Stage Alzheimer’s Disease Dementia publication-title: J. Alzheimer’s Dis. – reference: V. Pandey, A. Gadeval, S. Asati, P. Jain, N. Jain, R.K. Roy, M. Tekade, V. Soni, R.K. Tekade, Formulation strategies for nose-to-brain delivery of therapeutic molecules, Elsevier Inc., 2019. https://doi.org/10.1016/B978-0-12-814487-9.00007-7. – volume: 17 start-page: 839 year: 2020 end-page: 853 ident: b0185 article-title: Nose-to-brain delivery of antipsychotics using nanotechnology: a review publication-title: Expert Opin. Drug Deliv. – volume: 579 year: 2020 ident: b0360 article-title: Nose to brain delivery of rotigotine loaded chitosan nanoparticles in human SH-SY5Y neuroblastoma cells and animal model of Parkinson’s disease publication-title: Int. J. Pharm. – reference: FDA, Inactive Ingredients Database Download, (2021). https://www.fda.gov/drugs/drug-approvals-and-databases/inactive-ingredients-database-download (accessed February 16, 2021). – volume: 106 start-page: 386 year: 2018 end-page: 396 ident: b1055 article-title: Rheological properties of synthetic mucus for airway clearance: Rheological Properties of Synthetic Mucus publication-title: J. Biomed. Mater. Res. Part A. – volume: 15 start-page: 369 year: 2018 end-page: 378 ident: b0645 article-title: Lipid nanoparticles for intranasal administration: application to nose-to-brain delivery publication-title: Expert Opin. Drug Deliv. – volume: 582 year: 2020 ident: b0820 article-title: In vitro assessment of an idealized nose for nasal spray testing: Comparison with regional deposition in realistic nasal replicas publication-title: Int. J. Pharm. – volume: 14 start-page: 35007 year: 2019 ident: b0950 article-title: Optimising the biocompatibility of 3D printed photopolymer constructs in vitro and in vivo publication-title: Biomed. Mater. – volume: 8 start-page: 8 year: 2021 ident: b0365 article-title: Chitosan coating of anionic liposomes containing sumatriptan succinate : a candidate for nasal administration publication-title: Nanomed. J. – volume: 559 start-page: 86 year: 2019 end-page: 101 ident: b0635 article-title: Updates on thermosensitive hydrogel for nasal, ocular and cutaneous delivery publication-title: Int. J. Pharm. – volume: 36 year: 2019 ident: b0550 article-title: Increased Nose-to-Brain Delivery of Melatonin Mediated by Polycaprolactone Nanoparticles for the Treatment of Glioblastoma publication-title: Pharm. Res. – volume: 52 start-page: 1008 year: 2019 end-page: 1020 ident: b0275 article-title: Intranasal dolutegravir sodium loaded nanoparticles of hydroxypropyl-beta-cyclodextrin for brain delivery in Neuro-AIDS publication-title: J. Drug Deliv. Sci. Technol. – volume: 12 year: 2020 ident: b0520 article-title: Spray dried formulations for inhalation—meaningful characterisation of powder properties publication-title: Pharmaceutics. – volume: 42 start-page: 100 year: 2011 end-page: 113 ident: b0685 article-title: Simulation of sprayed particle deposition in a human nasal cavity including a nasal spray device publication-title: J. Aerosol Sci. – volume: 42 start-page: 52 year: 2011 end-page: 63 ident: b0965 article-title: Effects of surface smoothness on inertial particle deposition in human nasal models publication-title: J. Aerosol Sci. – volume: 13 year: 2018 ident: b0900 article-title: Improvement of quality of 3D printed objects by elimination of microscopic structural defects in fused deposition modeling publication-title: PLoS ONE – volume: 19 start-page: 58 year: 2012 end-page: 67 ident: b0470 article-title: Carbamazepine Mucoadhesive Nanoemulgel (MNEG) as brain targeting delivery system via the olfactory mucosa publication-title: Drug Deliv. – volume: 106 start-page: 386 year: 2018 end-page: 396 ident: b1040 article-title: Rheological properties of synthetic mucus for airway clearance publication-title: J. Biomed. Mater. Res. - Part A. – volume: 114 start-page: 197 year: 1995 end-page: 203 ident: b0375 article-title: Effects of formulation variables on nasal epithelial cell integrity: Biochemical evaluations publication-title: Int. J. Pharm. – volume: 8 start-page: 54 year: 2020 end-page: 59 ident: b0940 article-title: Trends in Selective Laser Sintering in Biomedical Engineering publication-title: Int. J. Emerg. Trends Eng. Res. – volume: 4 start-page: 4519 year: 2019 end-page: 4528 ident: b0280 article-title: Dendrimer donepezil conjugates for improved brain delivery and better in vivo pharmacokinetics publication-title: ACS Omega – volume: 10 start-page: 8 year: 2018 end-page: 10 ident: b0570 article-title: The role of combined penetration enhancers in nasal microspheres on in vivo drug bioavailability publication-title: Pharmaceutics. – volume: 56 start-page: 3 year: 2010 end-page: 17 ident: b0530 article-title: Is nose-to-brain transport of drugs in man a reality? publication-title: J. Pharm. Pharmacol. – volume: 62 year: 2021 ident: b0505 article-title: Formulation and evaluation of inhalable microparticles of Rizatriptan Benzoate processed by spray freeze-drying publication-title: J. Drug Deliv Sci. Technol. – volume: 5 start-page: 12 year: 2016 end-page: 20 ident: b0140 article-title: Pharmaceutical Preformulation Studies in Formulation and Development of New Dosage Form: A Review publication-title: Int. J. Pharma Res. Rev. – volume: 3 start-page: 131 year: 2015 end-page: 140 ident: b0225 article-title: pKa-critical interpretations of solubility-pH Profiles: PG-300995 and NSC-639829 case studies publication-title: ADMET DMPK. – volume: 570 year: 2019 ident: b0070 article-title: Strategies to facilitate or block nose-to-brain drug delivery publication-title: Int. J. Pharm. – volume: 222 start-page: 1013 year: 2008 end-page: 1022 ident: b0105 article-title: Development of a nasal cast model to test medicinal nasal devices publication-title: Proc. Inst. Mech. Eng. Part H J. Eng. Med. – volume: 6 start-page: 352 year: 2016 end-page: 358 ident: b0230 article-title: Nose-to-brain delivery of macromolecules mediated by cell-penetrating peptides publication-title: Acta Pharm. Sin. B. – year: 2021 ident: b0330 article-title: Stability of lyophilized and spray dried vaccine formulations publication-title: Adv. Drug Deliv. Rev. – volume: 9 start-page: 595 year: 2012 end-page: 612 ident: b0710 article-title: Coaxial electrospray of microparticles and nanoparticles for biomedical applications publication-title: Expert Rev. Med. Devices. – volume: 13 start-page: 1 year: 2020 end-page: 15 ident: b0675 article-title: Liquid crystalline nanoparticles for nasal delivery of rosuvastatin: Implications on therapeutic efficacy in management of epilepsy publication-title: Pharmaceuticals. – volume: 2 start-page: 41 year: 2019 end-page: 47 ident: b1065 article-title: Optimization of 3D-printed microstructures for investigating the properties of the mucus biobarrier publication-title: Micro Nano Eng. – reference: J. Xi, T. Demski, Y. Fallatah, K. Mcdonnell, SM Gr up SM Journal of Biomedical Engineering Experimental Test of Olfactory Deposition of Charged Particles under Electric Field Guidance and Bi- directional Breathing Conditions, 2 (2016) 1–7. – volume: 499 start-page: 376 year: 2016 end-page: 394 ident: b0860 article-title: 3D printing in pharmaceutics: A new tool for designing customized drug delivery systems publication-title: Int. J. Pharm. – volume: 25 start-page: 185 year: 2020 end-page: 194 ident: b0020 article-title: Nose-to-brain delivery of antiglioblastoma drugs embedded into lipid nanocarrier systems: status quo and outlook publication-title: Drug Discov. Today. – volume: 68 start-page: 1028 year: 1979 end-page: 1032 ident: b0250 article-title: Osmolality of parenteral solutions publication-title: J. Pharm. Sci. – volume: 70 start-page: 367 year: 2020 end-page: 375 ident: b0555 article-title: Development of Nasal Mucoadhesive Microspheres of Granisetron: A Potential Drug publication-title: Drug Res. (Stuttg) – volume: 17 start-page: 182 year: 2016 ident: b0870 article-title: Three-Dimensional Printing: Basic Principles and Applications in Medicine and Radiology publication-title: Korean J. Radiol. – volume: 31 start-page: 228 year: 2014 end-page: 237 ident: b1000 article-title: Validation of anatomical models to study aerosol deposition in human nasal cavities publication-title: Pharm. Res. – volume: 25 start-page: 558 year: 2000 end-page: 560 ident: b0390 article-title: The effect of hypertonicity on nasal mucociliary clearance publication-title: Clin. Otolaryngol. Allied Sci. – volume: 4 start-page: 311 year: 1991 end-page: 315 ident: b1050 article-title: Role of simulated repetitive coughing in mucus clearance publication-title: Eur. Respir. – volume: 8 start-page: 297 year: 2016 end-page: 308 ident: b0350 article-title: Preparation, characterisation and colloidal stability of chitosan-tripolyphosphate nanoparticles: Optimisation of formulation and process parameters publication-title: Int. J. Pharm. Pharm. Sci. – volume: 113 start-page: 2 year: 2018 end-page: 17 ident: b0605 article-title: Opportunity and challenges of nasal powders: Drug formulation and delivery publication-title: Eur. J. Pharm. Sci. – volume: 1 start-page: 1 year: 2013 end-page: 20 ident: b0145 article-title: Preformulation Studies of Pharmaceutical New Drug Molecule & Products: An Overview publication-title: Am. J. Pharm. Heal. Res. – volume: 18 start-page: 904 year: 2017 end-page: 912 ident: b0315 article-title: Improved Flux of Levodopa via Direct Deposition of Solid Microparticles on Nasal Tissue publication-title: AAPS PharmSciTech. – volume: 9 year: 2019 ident: b0895 article-title: Revealing interactions of layered polymeric materials at solid-liquid interface for building solvent compatibility charts for 3D printing applications publication-title: Sci. Rep. – volume: 592 year: 2021 ident: b0435 article-title: Intranasal fosphenytoin: The promise of phosphate esters in nose-to-brain delivery of poorly soluble drugs publication-title: Int. J. Pharm. – volume: 117 start-page: 10212 year: 2017 end-page: 10290 ident: b0890 article-title: Polymers for 3D Printing and Customized Additive Manufacturing publication-title: Chem. Rev. – volume: 12 start-page: 86 year: 2020 end-page: 93 ident: b0415 article-title: Zolmitriptan brain targeting via intranasal route using solid lipid nanoparticles for migraine therapy: Formulation, characterization, in-vitro and in-vivo assessment publication-title: Int. J. Appl. Pharm. – volume: 46 start-page: 299 year: 2013 end-page: 306 ident: b0810 article-title: Patient specific CFD models of nasal airflow: Overview of methods and challenges publication-title: J. Biomech. – volume: 7 start-page: 884 year: 2010 end-page: 893 ident: b0060 article-title: Trigeminal Pathways Deliver a Low Molecular Weight Drug from the Nose to the Brain and Orofacial Structures publication-title: Mol. Pharm. – volume: 292 start-page: 223 year: 2016 end-page: 231 ident: b0775 article-title: Carrier-based dry powder formulation for nasal delivery of vaccines utilizing BSA as model drug publication-title: Powder Technol. – volume: 101 start-page: 660 year: 2019 end-page: 673 ident: b0945 article-title: Development of a solvent-free polylactide/calcium carbonate composite for selective laser sintering of bone tissue engineering scaffolds publication-title: Mater. Sci. Eng. C. – volume: 2 start-page: 1391 year: 2011 end-page: 1400 ident: b0150 article-title: Pharmaceutical Preformulation Studies – Current Review publication-title: Int. J. Pharm. Biol. Arch. – volume: 147 start-page: 233 year: 1997 end-page: 242 ident: b0380 article-title: The influence of tonicity and viscosity on the intranasal absorption of salmon calcitonin in rabbits publication-title: Int. J. Pharm. – reference: N.R. Hussein, H.K. Omer, A.M.A. Elhissi, W. Ahmed, Advances in nasal drug delivery systems, Elsevier Inc., 2020. https://doi.org/10.1016/b978-0-12-819712-7.00015-2. – volume: 131 start-page: 5 year: 2021 end-page: 9 ident: b0975 article-title: Olfactory Cleft Width and Volume: Possible Risk Factors for Postinfectious Olfactory Dysfunction publication-title: Laryngoscope. – volume: 5 start-page: 28 year: 2020 ident: b0480 article-title: Nasal vaccine delivery attenuates brain pathology and cognitive impairment in tauopathy model mice publication-title: npj Vaccines – reference: S.T. Charlton, S.S. Davis, L. Illum, Evaluation of bioadhesive polymers as delivery systems for nose to brain delivery : In vitro characterisation studies, 118 (2007) 225–234. https://doi.org/10.1016/j.jconrel.2006.12.014. – volume: 72 start-page: 1341 year: 2020 end-page: 1351 ident: b0305 article-title: Nose-to-brain delivery of sumatriptan-loaded nanostructured lipid carriers: preparation, optimization, characterization and pharmacokinetic evaluation publication-title: J. Pharm. Pharmacol. – volume: 29 start-page: 264 year: 2019 end-page: 273 ident: b0370 article-title: Nanostructured cubosomes in an in situ nasal gel system: an alternative approach for the controlled delivery of donepezil HCl to brain publication-title: J. Liposome Res. – volume: 7 start-page: 967 year: 2002 end-page: 975 ident: b0195 article-title: Permeability issues in nasal drug delivery publication-title: Drug Discov. Today. – volume: 185 year: 2020 ident: b0270 article-title: In vitro investigations on dopamine loaded Solid Lipid Nanoparticles publication-title: J. Pharm. Biomed. Anal. – volume: 44 start-page: 953 year: 2018 end-page: 960 ident: b0585 article-title: Preparation and evaluation of carfentanil nasal spray employing cyclodextrin inclusion technology publication-title: Drug Dev. Ind. Pharm. – volume: 101 start-page: 31 year: 2012 end-page: 47 ident: b0320 article-title: Stable dry powder formulation for nasal delivery of anthrax vaccine publication-title: J. Pharm. Sci. – volume: 8 start-page: 19 year: 2013 end-page: 50 ident: b0905 article-title: Multiple material additive manufacturing – Part 1: a review publication-title: Virtual Phys. Prototyp. – volume: 33 start-page: 258 year: 2020 end-page: 270 ident: b0050 article-title: Olfactory Targeting of Microparticles through Inhalation and Bi-directional Airflow: Effect of Particle Size and Nasal Anatomy publication-title: J. Aerosol Med. Pulm. Drug Deliv. – volume: 146 start-page: 313 year: 2012 end-page: 319 ident: b0705 article-title: Effects of anatomy and particle size on nasal sprays and nebulizers publication-title: Otolaryngol. - Head Neck Surg. – volume: 28 start-page: e557 year: 2019 end-page: e562 ident: b0955 article-title: Accuracy of Dental Replica Models Using Photopolymer Materials in Additive Manufacturing. In Vitro Three-Dimensional Evaluation publication-title: J. Prosthodont. – volume: 327 start-page: 235 year: 2020 end-page: 265 ident: b0625 article-title: Stimuli-responsive In situ gelling system for nose-to-brain drug delivery publication-title: J. Control. Release. – volume: 48 year: 2010 ident: b0515 article-title: A review of the implications of computational fluid dynamic studies on nasal airflow and physiology publication-title: Rhinol. J. – volume: 302 start-page: 140 year: 2019 end-page: 147 ident: b0125 article-title: Characterisation of nasal devices for delivery of insulin to the brain and evaluation in humans using functional magnetic resonance imaging publication-title: J. Control. Release. – volume: 21 start-page: 1 year: 2020 end-page: 17 ident: b0420 article-title: Liposome consolidated with cyclodextrin provides prolonged drug retention resulting in increased drug bioavailability in brain publication-title: Int. J. Mol. Sci. – volume: 292 start-page: 111 year: 2018 end-page: 118 ident: b0325 article-title: Intranasal immunization with aluminum salt-adjuvanted dry powder vaccine publication-title: J. Control. Release. – volume: 27 start-page: 21 year: 2014 end-page: 29 ident: b0115 article-title: Design of Experiments to Optimize an In Vitro Cast to Predict Human Nasal Drug Deposition publication-title: J. Aerosol Med. Pulm. Drug Deliv. – volume: 266 start-page: 1675 year: 2009 end-page: 1680 ident: b0540 article-title: The human olfactory mucosa publication-title: Eur. Arch. Oto-Rhino-Laryngology. – volume: 49 start-page: 143 year: 2020 end-page: 148 ident: b0935 article-title: Can an entry-level 3D printer create high-quality anatomical models? Accuracy assessment of mandibular models printed by a desktop 3D printer and a professional device publication-title: Int. J. Oral Maxillofac. Surg. – volume: 29 start-page: 153 year: 2016 end-page: 166 ident: b0830 article-title: A Computational Study of Nasal Spray Deposition Pattern in Four Ethnic Groups publication-title: J. Aerosol Med. Pulm. Drug Deliv. – volume: 15 start-page: 1392 year: 2018 end-page: 1402 ident: b0120 article-title: Personalized Medicine in Nasal Delivery: The Use of Patient-Specific Administration Parameters To Improve Nasal Drug Targeting Using 3D-Printed Nasal Replica Casts publication-title: Mol. Pharm. – year: 2020 ident: b0930 article-title: Using 3D printed sinonasal models to visualize and optimize personalized sinonasal sinus irrigation strategies publication-title: Rhinol. J. – volume: 24 start-page: 116 year: 2020 end-page: 122 ident: b0560 article-title: The dry powder formulation of mixed cross-linked dextran microspheres and tetanus toxoid-loaded trimethyl chitosan nanospheres as a potent adjuvant for nasal delivery system publication-title: Iran. J. Basic Med. Sci. – volume: 10 start-page: 1 year: 2018 end-page: 9 ident: b0085 article-title: A review on strategies for improving nasal drug delivery systems publication-title: Drug Invent. Today. – volume: 7 start-page: 1184 year: 2002 end-page: 1189 ident: b0180 article-title: Nasal drug delivery: New developments and strategies publication-title: Drug Discov. Today. – volume: 104 start-page: 1661 year: 2019 end-page: 1676 ident: b0880 article-title: Modelling of the temperature and residual stress fields during 3D printing of polymer composites publication-title: Int. J. Adv. Manuf. Technol. – volume: 25 start-page: 215 year: 2009 end-page: 221 ident: b0840 article-title: Management of the Aging Nose publication-title: Facial Plast. Surg. – volume: 9 start-page: 1 year: 2016 end-page: 14 ident: b1070 article-title: Effects of the surface physico-chemical properties and the surface textures on the initial colonization and the attached growth in algal biofilm publication-title: Biotechnol. Biofuels. – volume: 19 start-page: 468 year: 2011 end-page: 474 ident: b0345 article-title: Brain targeting of risperidone-loaded solid lipid nanoparticles by intranasal route publication-title: J. Drug Target. – volume: 10 start-page: 1044 year: 2020 end-page: 1056 ident: b0025 article-title: Nose-to-brain delivery: exploring newer domains for glioblastoma multiforme management publication-title: Drug Deliv. Transl. Res. – volume: 24 start-page: 645 year: 2018 end-page: 669 ident: b0865 article-title: A review on quality control in additive manufacturing publication-title: Rapid Prototyp. J. – volume: 21 start-page: 1 year: 2020 end-page: 23 ident: b0575 article-title: New opportunity to formulate intranasal vaccines and drug delivery systems based on chitosan publication-title: Int. J. Mol. Sci. – volume: 105 start-page: 593 year: 2017 end-page: 612 ident: b0850 article-title: Overview on Additive Manufacturing Technologies publication-title: Proc. IEEE. – volume: 11 start-page: 1 year: 2000 end-page: 18 ident: b0065 article-title: Transport of drugs from the nasal cavity to the central nervous system publication-title: Eur. J. Pharm. Sci. – volume: 124 start-page: 3 year: 2018 end-page: 15 ident: b0960 article-title: The biology of mucus: Composition, synthesis and organization publication-title: Adv. Drug Deliv. Rev. – reference: Ç.Y.A. et C.J. M., Fluid mechanics: fundamentals and applications, 3e edition, 2014, New York, n.d. – volume: 105 year: 2019 ident: b0695 article-title: Electrospray for generation of drug delivery and vaccine particles applied in vitro and in vivo publication-title: Mater. Sci. Eng. C. – volume: 577 start-page: 1 year: 2020 end-page: 9 ident: b0400 article-title: Facile nose-to-brain delivery of rotigotine-loaded polymer micelles thermosensitive hydrogels: In vitro characterization and in vivo behavior study publication-title: Int. J. Pharm. – volume: 328 start-page: 01006 year: 2020 ident: b0730 article-title: Characterization of Aerosol Nebulized by Aerogen Solo Mesh Nebulizer publication-title: MATEC Web Conf. – volume: 42 start-page: 1107 year: 2003 end-page: 1128 ident: b0595 article-title: Absorption Enhancers for Nasal Drug Delivery publication-title: Clin. Pharmacokinet. – volume: 9 year: 2018 ident: b0920 article-title: Highly fluorinated methacrylates for optical 3D printing of microfluidic devices publication-title: Micromachines. – volume: 12 start-page: 1 year: 2020 end-page: 27 ident: b0650 article-title: Double optimization of rivastigmine-loaded nanostructured lipid carriers (NLC) for nose-to-brain delivery using the quality by design (QbD) approach: Formulation variables and instrumental parameters publication-title: Pharmaceutics. – volume: 26 start-page: 1618 year: 2009 end-page: 1625 ident: b0610 article-title: Clinical study shows improved absorption of desmopressin with novel formulation publication-title: Pharm. Res. – volume: 31 start-page: 108 year: 2016 end-page: 117 ident: b0405 article-title: In vitro, ex vivo and in vivo performance of chitosan-based spray-dried nasal mucoadhesive microspheres of diltiazem hydrochloride publication-title: J. Drug Deliv. Sci. Technol. – volume: 32 start-page: 77 year: 2016 end-page: 87 ident: b0545 article-title: Particulate formulations based on chitosan for nose-to-brain delivery of drugs. A review publication-title: J. Drug Deliv Sci. Technol. – volume: 35 year: 2018 ident: b0110 article-title: In Vitro Assessment of Spray Deposition Patterns in a Pediatric (12 Year-Old) Nasal Cavity Model publication-title: Pharm. Res. – volume: 28 start-page: 962 year: 2011 end-page: 977 ident: b0200 article-title: Lipophilicity and its relationship with passive drug permeation publication-title: Pharm. Res. – volume: 15 start-page: 167 year: 2001 end-page: 174 ident: b0095 article-title: Administration intranasale des médicaments pour une action systémique publication-title: La Lett. Du Pharmacol. – volume: 3 start-page: 299 year: 2013 end-page: 306 ident: b0825 article-title: The aerodynamics of the sinonasal interface: the nose takes wing-a paradigm shift for our time publication-title: Int. Forum Allergy Rhinol. – volume: 29 start-page: 13 year: 1998 end-page: 38 ident: b0525 article-title: Nasal mucociliary clearance as a factor in nasal drug delivery publication-title: Adv. Drug Deliv. Rev. – volume: 431 start-page: 138 year: 2012 end-page: 148 ident: b0165 article-title: Clotrimazole nanoemulsion for malaria chemotherapy. Part I: Preformulation studies, formulation design and physicochemical evaluation publication-title: Int. J. Pharm. – year: 2021 ident: b0265 article-title: Nose to brain delivery of Rotigotine loaded solid lipid nanoparticles: Quality by Design based optimization and characterization publication-title: J. Drug Deliv Sci. Technol. – volume: 16 start-page: 25 year: 2020 ident: b0740 article-title: The Upper Nasal Space—A Novel Delivery Route Ideal for Central Nervous System Drugs publication-title: US Neurol. – volume: 379 start-page: 144 year: 2021 end-page: 153 ident: b0500 article-title: Microfluidic spray dried and spray freeze dried uniform microparticles potentially for intranasal drug delivery and controlled release publication-title: Powder Technol. – volume: 16 start-page: 123 year: 2018 end-page: 135 ident: b0295 article-title: Formulation and Evaluation of Neuroactive Drug Loaded Chitosan Nanoparticle for Nose to Brain Delivery: In-vitro Characterization and In-vivo Behavior Study publication-title: Curr. Drug Deliv. – volume: 77 start-page: 40 year: 2016 end-page: 48 ident: b0690 article-title: Effects of nasal drug delivery device and its orientation on sprayed particle deposition in a realistic human nasal cavity publication-title: Comput. Biol. Med. – volume: 1726 year: 2020 ident: b0655 article-title: Pharmacokinetics, pharmacodynamics and toxicity of Baicalin liposome on cerebral ischemia reperfusion injury rats via intranasal administration publication-title: Brain Res. – volume: 234 start-page: 41 year: 2016 end-page: 48 ident: b0855 article-title: 3D scanning and 3D printing as innovative technologies for fabricating personalized topical drug delivery systems publication-title: J. Control. Release. – volume: 17 start-page: 127 year: 2020 end-page: 132 ident: b0045 article-title: A consensus research agenda for optimising nasal drug delivery publication-title: Expert Opin. Drug Deliv. – year: 2010 ident: b0160 publication-title: Biotechnology: Pharmaceutical Aspects – volume: 35 start-page: 357 year: 2018 end-page: 371 ident: b0335 article-title: A comparative study of stabilising effect and antioxidant activity of different antioxidants on levodopa-loaded liposomes publication-title: J. Microencapsul. – volume: 3 start-page: 905 year: 2013 end-page: 910 ident: b0755 article-title: A novel device for delivery of intranasal particulate medication: a pilot study: Novel device for nasal particulate delivery publication-title: Int. Forum Allergy & Rhinol. – volume: 33 start-page: 1527 year: 2016 end-page: 1541 ident: b0130 article-title: Visualization and Quantification of Nasal and Olfactory Deposition in a Sectional Adult Nasal Airway Cast publication-title: Pharm. Res. – volume: 28 start-page: 1895 year: 2011 end-page: 1904 ident: b1020 article-title: Effect of formulation- and administration-related variables on deposition pattern of nasal spray pumps evaluated using a nasal cast publication-title: Pharm. Res. – volume: 392 start-page: 1 year: 2010 end-page: 19 ident: b0485 article-title: Formulation strategy and use of excipients in pulmonary drug delivery publication-title: Int. J. Pharm. – volume: 105 start-page: 1995 year: 2016 end-page: 2004 ident: b0245 article-title: Linking Suspension Nasal Spray Drug Deposition Patterns to Pharmacokinetic Profiles: A Proof-of-Concept Study Using Computational Fluid Dynamics publication-title: J. Pharm. Sci. – volume: 56 start-page: 730 year: 2007 end-page: 759 ident: b0800 article-title: Consolidation phenomena in laser and powder-bed based layered manufacturing publication-title: CIRP Ann. - Manuf. Technol. – volume: 106 start-page: 784 year: 2009 end-page: 795 ident: b0845 article-title: Creation of a standardized geometry of the human nasal cavity publication-title: J. Appl. Physiol. – reference: H.W. C., Aerosol technology: properties, behavior, and measurement of airborne particles, 2e edition, 1999, New York, n.d. – volume: 69 start-page: 68 year: 2021 end-page: 76 ident: b0885 article-title: Geometric precision analysis for Additive Manufacturing processes: A comparative study publication-title: Precis. Eng. – volume: 213 start-page: 187 year: 2001 end-page: 192 ident: b0385 article-title: In situ nasal absorption of midazolam in rats publication-title: Int. J. Pharm. – volume: 548 start-page: 305 year: 2018 end-page: 313 ident: b0440 article-title: A modified USP induction port to characterize nasal spray plume geometry and predict turbinate deposition under flow publication-title: Int. J. Pharm. – volume: 162 start-page: 194 year: 2012 end-page: 200 ident: b0600 article-title: CriticalSorb publication-title: J. Control. Release. – volume: 8 start-page: 169 year: 2019 end-page: 177 ident: b0015 article-title: Nasal drug delivery system: A innovative approach, ~ 169 ~ Pharma Innov publication-title: J. – volume: 14 start-page: 267 year: 2001 end-page: 280 ident: b0790 article-title: Characterization of Nasal Spray Pumps and Deposition Pattern in a Replica of the Human Nasal Airway publication-title: J. Aerosol Med. – volume: 2 start-page: 4 year: 1996 end-page: 19 ident: b0795 article-title: Structural quality of parts processed by fused deposition publication-title: Rapid Prototyp. J. – volume: 99 start-page: 1745 year: 2010 end-page: 1761 ident: b0475 article-title: Brain delivery of proteins by the intranasal route of administration: A comparison of cationic liposomes versus aqueous solution formulations publication-title: J. Pharm. Sci. – volume: 164 start-page: 799 year: 1949 end-page: 800 ident: b1035 article-title: Mixture law for viscosity [21] publication-title: Nature – volume: 11 year: 2019 ident: b0535 article-title: Improved in vitro model for intranasal mucosal drug delivery: Primary olfactory and respiratory epithelial cells compared with the permanent Nasal cell line RPMI 2650 publication-title: Pharmaceutics. – volume: 21 start-page: 1 year: 2021 ident: b0915 article-title: Assessment of the reproducibility and precision of milling and 3D printing surgical guides publication-title: BMC Oral Health. – volume: 119 start-page: 1730 year: 2009 end-page: 1736 ident: b0100 article-title: Assessment of septal deviation effects on nasal air flow: A computational fluid dynamics model: Nasal Air Flow with Septal Deviation publication-title: Laryngoscope. – volume: 454 start-page: 573 year: 2013 end-page: 583 ident: b0175 article-title: Long chain lipid based tamoxifen NLC. Part I: Preformulation studies, formulation development and physicochemical characterization publication-title: Int. J. Pharm. – volume: 11 start-page: 1 year: 2019 end-page: 20 ident: b0075 article-title: Strategies to enhance drug absorption via nasal and pulmonary routes publication-title: Pharmaceutics. – volume: 129 start-page: 257 year: 2018 end-page: 266 ident: b0155 article-title: Chitosan-coated liposome dry-powder formulations loaded with ghrelin for nose-to-brain delivery publication-title: Eur. J. Pharm. Biopharm. – volume: 130 start-page: 433 year: 2017 end-page: 441 ident: b0300 article-title: Compatibility study between antiparkinsonian drug Levodopa and excipients by FTIR spectroscopy, X-ray diffraction and thermal analysis publication-title: J. Therm. Anal. Calorim. – volume: 12 start-page: 2559 year: 2017 end-page: 2571 ident: b0970 article-title: Comparison of pulsed versus continuous oxygen delivery using realistic adult nasal airway replicas publication-title: Int. J. Chron. Obstruct. Pulmon. Dis. – volume: 281 start-page: 139 year: 2018 end-page: 177 ident: b0035 article-title: Nose-to-brain drug delivery: An update on clinical challenges and progress towards approval of anti-Alzheimer drugs publication-title: J. Control. Release. – volume: 13 start-page: 34 year: 2017 end-page: 45 ident: b0620 article-title: Current prospects and future challenges for nasal vaccine delivery publication-title: Hum. Vaccines Immunother. – volume: 20 start-page: 495 year: 2007 end-page: 508 ident: b0765 article-title: The Influence of Spray Properties on Intranasal Deposition publication-title: J. Aerosol Med. – volume: 307 start-page: 76 year: 2019 end-page: 89 ident: b0410 article-title: Nose-to-brain delivery of hyaluronate – FG loop peptide conjugate for non-invasive hypoxic-ischemic encephalopathy therapy publication-title: J. Control. Release. – volume: 23 start-page: 775 year: 2015 end-page: 788 ident: b0030 article-title: Nanotechnology-mediated nose to brain drug delivery for Parkinson’s disease: A mini review publication-title: J. Drug Target. – volume: 98 start-page: 121 year: 2018 end-page: 126 ident: b0925 article-title: Suitability of 3D-Printed devices for low-temperature geochemical experiments publication-title: Appl. Geochemistry. – volume: 3 start-page: 42 year: 2013 end-page: 62 ident: b0750 article-title: Nasal drug delivery devices: characteristics and performance in a clinical perspective—a review publication-title: Drug Deliv. Transl. Res. – volume: 159 year: 2021 ident: b0290 article-title: Mucoadhesive nanostructured lipid carriers as a cannabidiol nasal delivery system for the treatment of neuropathic pain publication-title: Eur. J. Pharm. Sci. – volume: 538 start-page: 223 year: 2018 end-page: 230 ident: b0995 article-title: 3D extrusion printing of high drug loading immediate release paracetamol tablets publication-title: Int. J. Pharm. – volume: 42 start-page: 74 year: 2019 end-page: 78 ident: b0590 article-title: Quantitative determination of beta-cyclodextrin in a powder insulin formulation for nasal delivery using hydrophilic interaction chromatography with evaporative light scattering detection publication-title: J. Liq. Chromatogr. Relat. Technol. – volume: 61 start-page: 75 year: 2009 end-page: 85 ident: b1045 article-title: Barrier properties of mucus publication-title: Adv. Drug Deliv. Rev. – volume: 27 start-page: 984 year: 2019 end-page: 994 ident: b0495 article-title: Anti-inflammatory flurbiprofen nasal powders for nose-to-brain delivery in Alzheimer’s disease publication-title: J. Drug Target. – volume: 10 start-page: 344 year: 2020 end-page: 350 ident: b0660 article-title: Brain Targeted Delivery of Rizatriptan using Glutathione Conjugated Liposomes through Transmucosal Nasal Route publication-title: Int. J. Pharm. Investig. – volume: 1 start-page: 21 year: 2011 end-page: 28 ident: b0190 article-title: Advances in nasal trans-mucosal drug delivery publication-title: J. Appl. Pharm. Sci. – volume: 24 start-page: 557 year: 1987 end-page: 563 ident: b1060 article-title: Rheological properties controlling mucociliary frequency and respiratory mucus transport publication-title: Biorheology. – volume: 46 start-page: 1161 year: 2008 end-page: 1167 ident: b0815 article-title: Numerical flow simulation in the post-endoscopic sinus surgery nasal cavity publication-title: Med. Biol. Eng. Comput. – volume: 9 start-page: 19 year: 2012 end-page: 31 ident: b0205 article-title: Physicochemical and physiological considerations for efficient nose-to-brain targeting publication-title: Expert Opin. Drug Deliv. – reference: J.D. Ehrick, S.A. Shah, C. Shaw, V.S. Kulkarni, I. Coowanitwong, S. De, J.D. Suman, Considerations for the Development of Nasal Dosage Forms, in: 2013: pp. 99–144. https://doi.org/10.1007/978-1-4614-7978-9_5. – volume: 105 start-page: 1209 year: 2016 end-page: 1220 ident: b0805 article-title: Development and Evaluation of a Novel Intranasal Spray for the Delivery of Amantadine publication-title: J. Pharm. Sci. – volume: 52 start-page: 242 year: 2019 end-page: 247 ident: b0875 article-title: Innovative Extruder Concept for Fast and Efficient Additive Manufacturing publication-title: IFAC-PapersOnLine. – volume: 550 start-page: 35 year: 2018 end-page: 44 ident: b0340 article-title: Spray dried cubosomes with ovalbumin and Quil-A as a nanoparticulate dry powder vaccine formulation publication-title: Int. J. Pharm. – volume: 48 start-page: 930 year: 2014 end-page: 938 ident: b0445 article-title: A Comparison of the Deposition Patterns of Different Nasal Spray Formulations Using a Nasal Cast publication-title: Aerosol Sci. Technol. – volume: 5 year: 2017 ident: b0080 article-title: Intranasal Drug Delivery: A Non-Invasive Approach for the Better Delivery of Neurotherapeutics publication-title: Pharm. Nanotechnol. – volume: 574 year: 2020 ident: b0785 article-title: Impact of physicochemical properties of nasal spray products on drug deposition and transport in the pediatric nasal cavity model publication-title: Int. J. Pharm. – volume: 25 start-page: 290 year: 2020 end-page: 299 ident: b0260 article-title: Spray-dried alginate microparticles for potential intranasal delivery of ropinirole hydrochloride: development, characterization and histopathological evaluation publication-title: Pharm. Dev. Technol. – volume: 76 start-page: 535 year: 1987 end-page: 540 ident: b0240 article-title: Analysis of Structural Requirements for the Absorption of Drugs and Macromolecules from the Nasal Cavity publication-title: J. Pharm. Sci. – volume: 34 start-page: 423 year: 2019 end-page: 432 ident: b0355 article-title: Curcumin loaded TPGS micelles for nose to brain drug delivery: in vitro and in vivo studies publication-title: Mater. Technol. – volume: 11 year: 2019 ident: 10.1016/j.addr.2021.113826_b0535 article-title: Improved in vitro model for intranasal mucosal drug delivery: Primary olfactory and respiratory epithelial cells compared with the permanent Nasal cell line RPMI 2650 publication-title: Pharmaceutics. doi: 10.3390/pharmaceutics11080367 – volume: 117 start-page: 10212 year: 2017 ident: 10.1016/j.addr.2021.113826_b0890 article-title: Polymers for 3D Printing and Customized Additive Manufacturing publication-title: Chem. Rev. doi: 10.1021/acs.chemrev.7b00074 – volume: 105 start-page: 593 year: 2017 ident: 10.1016/j.addr.2021.113826_b0850 article-title: Overview on Additive Manufacturing Technologies publication-title: Proc. IEEE. doi: 10.1109/JPROC.2016.2625098 – volume: 3 start-page: 905 year: 2013 ident: 10.1016/j.addr.2021.113826_b0755 article-title: A novel device for delivery of intranasal particulate medication: a pilot study: Novel device for nasal particulate delivery publication-title: Int. Forum Allergy & Rhinol. doi: 10.1002/alr.21199 – volume: 17 start-page: 1996 year: 2020 ident: 10.1016/j.addr.2021.113826_b0665 article-title: Intranasal Delivery and Transfection of mRNA Therapeutics in the Brain Using Cationic Liposomes publication-title: Mol. Pharm. doi: 10.1021/acs.molpharmaceut.0c00170 – volume: 328 start-page: 01006 year: 2020 ident: 10.1016/j.addr.2021.113826_b0730 article-title: Characterization of Aerosol Nebulized by Aerogen Solo Mesh Nebulizer publication-title: MATEC Web Conf. doi: 10.1051/matecconf/202032801006 – volume: 527 start-page: 161 year: 2017 ident: 10.1016/j.addr.2021.113826_b0990 article-title: Patient-specific 3D scanned and 3D printed antimicrobial polycaprolactone wound dressings publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2017.04.077 – volume: 106 start-page: 784 year: 2009 ident: 10.1016/j.addr.2021.113826_b0845 article-title: Creation of a standardized geometry of the human nasal cavity publication-title: J. Appl. Physiol. doi: 10.1152/japplphysiol.90376.2008 – volume: 592 year: 2021 ident: 10.1016/j.addr.2021.113826_b0435 article-title: Intranasal fosphenytoin: The promise of phosphate esters in nose-to-brain delivery of poorly soluble drugs publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2020.120040 – volume: 52 start-page: 1008 year: 2019 ident: 10.1016/j.addr.2021.113826_b0275 article-title: Intranasal dolutegravir sodium loaded nanoparticles of hydroxypropyl-beta-cyclodextrin for brain delivery in Neuro-AIDS publication-title: J. Drug Deliv. Sci. Technol. doi: 10.1016/j.jddst.2019.06.014 – volume: 15 start-page: 369 year: 2018 ident: 10.1016/j.addr.2021.113826_b0645 article-title: Lipid nanoparticles for intranasal administration: application to nose-to-brain delivery publication-title: Expert Opin. Drug Deliv. doi: 10.1080/17425247.2018.1429401 – volume: 25 start-page: 376 year: 2018 ident: 10.1016/j.addr.2021.113826_b0210 article-title: In vivo nose-to-brain delivery of the hydrophilic antiviral ribavirin by microparticle agglomerates publication-title: Drug Deliv. doi: 10.1080/10717544.2018.1428242 – year: 2011 ident: 10.1016/j.addr.2021.113826_b0720 article-title: Novel advances in rapid manufacturing, deployment, and delivery of intranasally administered drugs and biologics publication-title: ONdrugDelivery. – volume: 101 start-page: 660 year: 2019 ident: 10.1016/j.addr.2021.113826_b0945 article-title: Development of a solvent-free polylactide/calcium carbonate composite for selective laser sintering of bone tissue engineering scaffolds publication-title: Mater. Sci. Eng. C. doi: 10.1016/j.msec.2019.03.101 – volume: 454 start-page: 573 year: 2013 ident: 10.1016/j.addr.2021.113826_b0175 article-title: Long chain lipid based tamoxifen NLC. Part I: Preformulation studies, formulation development and physicochemical characterization publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2013.03.034 – volume: 44 start-page: 953 year: 2018 ident: 10.1016/j.addr.2021.113826_b0585 article-title: Preparation and evaluation of carfentanil nasal spray employing cyclodextrin inclusion technology publication-title: Drug Dev. Ind. Pharm. doi: 10.1080/03639045.2018.1425426 – year: 2020 ident: 10.1016/j.addr.2021.113826_b0930 article-title: Using 3D printed sinonasal models to visualize and optimize personalized sinonasal sinus irrigation strategies publication-title: Rhinol. J. doi: 10.4193/Rhin19.314 – ident: 10.1016/j.addr.2021.113826_b0255 – volume: 36 year: 2019 ident: 10.1016/j.addr.2021.113826_b0550 article-title: Increased Nose-to-Brain Delivery of Melatonin Mediated by Polycaprolactone Nanoparticles for the Treatment of Glioblastoma publication-title: Pharm. Res. doi: 10.1007/s11095-019-2662-z – volume: 18 start-page: 904 year: 2017 ident: 10.1016/j.addr.2021.113826_b0315 article-title: Improved Flux of Levodopa via Direct Deposition of Solid Microparticles on Nasal Tissue publication-title: AAPS PharmSciTech. doi: 10.1208/s12249-016-0581-4 – volume: 15 start-page: 1392 year: 2018 ident: 10.1016/j.addr.2021.113826_b0120 article-title: Personalized Medicine in Nasal Delivery: The Use of Patient-Specific Administration Parameters To Improve Nasal Drug Targeting Using 3D-Printed Nasal Replica Casts publication-title: Mol. Pharm. doi: 10.1021/acs.molpharmaceut.7b00702 – volume: 41 start-page: 1922 year: 2015 ident: 10.1016/j.addr.2021.113826_b0215 article-title: Nanoneurotherapeutics approach intended for direct nose to brain delivery publication-title: Drug Dev. Ind. Pharm. doi: 10.3109/03639045.2015.1052081 – volume: 292 start-page: 223 year: 2016 ident: 10.1016/j.addr.2021.113826_b0775 article-title: Carrier-based dry powder formulation for nasal delivery of vaccines utilizing BSA as model drug publication-title: Powder Technol. doi: 10.1016/j.powtec.2016.01.042 – ident: 10.1016/j.addr.2021.113826_b0490 – volume: 62 year: 2021 ident: 10.1016/j.addr.2021.113826_b0505 article-title: Formulation and evaluation of inhalable microparticles of Rizatriptan Benzoate processed by spray freeze-drying publication-title: J. Drug Deliv Sci. Technol. – volume: 392 start-page: 1 year: 2010 ident: 10.1016/j.addr.2021.113826_b0485 article-title: Formulation strategy and use of excipients in pulmonary drug delivery publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2010.03.017 – volume: 559 start-page: 86 year: 2019 ident: 10.1016/j.addr.2021.113826_b0630 article-title: Updates on thermosensitive hydrogel for nasal, ocular and cutaneous delivery publication-title: Pharmaceutics. doi: 10.1016/j.ijpharm.2019.01.030 – volume: 21 start-page: 1 year: 2020 ident: 10.1016/j.addr.2021.113826_b0575 article-title: New opportunity to formulate intranasal vaccines and drug delivery systems based on chitosan publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms21145016 – volume: 38 start-page: 1072 year: 2004 ident: 10.1016/j.addr.2021.113826_b0910 article-title: Particle Deposition in Human Nasal Airway Replicas Manufactured by Different Methods. Part I: Inertial Regime Particles publication-title: Aerosol Sci. Technol. doi: 10.1080/027868290883432 – volume: 14 start-page: 35007 year: 2019 ident: 10.1016/j.addr.2021.113826_b0950 article-title: Optimising the biocompatibility of 3D printed photopolymer constructs in vitro and in vivo publication-title: Biomed. Mater. doi: 10.1088/1748-605X/ab09c4 – volume: 72 start-page: 1341 year: 2020 ident: 10.1016/j.addr.2021.113826_b0305 article-title: Nose-to-brain delivery of sumatriptan-loaded nanostructured lipid carriers: preparation, optimization, characterization and pharmacokinetic evaluation publication-title: J. Pharm. Pharmacol. doi: 10.1111/jphp.13316 – volume: 582 year: 2020 ident: 10.1016/j.addr.2021.113826_b0820 article-title: In vitro assessment of an idealized nose for nasal spray testing: Comparison with regional deposition in realistic nasal replicas publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2020.119341 – volume: 17 start-page: 4241 year: 2020 ident: 10.1016/j.addr.2021.113826_b0580 article-title: Preparation and Biophysical Characterization of Quercetin Inclusion Complexes with β-Cyclodextrin Derivatives to be Formulated as Possible Nose-to-Brain Quercetin Delivery Systems publication-title: Mol. Pharm. doi: 10.1021/acs.molpharmaceut.0c00672 – volume: 101 start-page: 31 year: 2012 ident: 10.1016/j.addr.2021.113826_b0320 article-title: Stable dry powder formulation for nasal delivery of anthrax vaccine publication-title: J. Pharm. Sci. doi: 10.1002/jps.22742 – volume: 4 start-page: 4519 year: 2019 ident: 10.1016/j.addr.2021.113826_b0280 article-title: Dendrimer donepezil conjugates for improved brain delivery and better in vivo pharmacokinetics publication-title: ACS Omega doi: 10.1021/acsomega.8b03445 – volume: 1 start-page: 1 year: 2013 ident: 10.1016/j.addr.2021.113826_b0145 article-title: Preformulation Studies of Pharmaceutical New Drug Molecule & Products: An Overview publication-title: Am. J. Pharm. Heal. Res. – volume: 28 start-page: e557 year: 2019 ident: 10.1016/j.addr.2021.113826_b0955 article-title: Accuracy of Dental Replica Models Using Photopolymer Materials in Additive Manufacturing. In Vitro Three-Dimensional Evaluation publication-title: J. Prosthodont. doi: 10.1111/jopr.12928 – volume: 266 start-page: 1675 year: 2009 ident: 10.1016/j.addr.2021.113826_b0540 article-title: The human olfactory mucosa publication-title: Eur. Arch. Oto-Rhino-Laryngology. doi: 10.1007/s00405-009-1073-x – volume: 234 start-page: 41 year: 2016 ident: 10.1016/j.addr.2021.113826_b0855 article-title: 3D scanning and 3D printing as innovative technologies for fabricating personalized topical drug delivery systems publication-title: J. Control. Release. doi: 10.1016/j.jconrel.2016.05.034 – volume: 26 start-page: 1618 year: 2009 ident: 10.1016/j.addr.2021.113826_b0610 article-title: Clinical study shows improved absorption of desmopressin with novel formulation publication-title: Pharm. Res. doi: 10.1007/s11095-009-9871-9 – volume: 33 start-page: 258 year: 2020 ident: 10.1016/j.addr.2021.113826_b0050 article-title: Olfactory Targeting of Microparticles through Inhalation and Bi-directional Airflow: Effect of Particle Size and Nasal Anatomy publication-title: J. Aerosol Med. Pulm. Drug Deliv. doi: 10.1089/jamp.2019.1549 – volume: 8 start-page: 8 issue: 2 year: 2021 ident: 10.1016/j.addr.2021.113826_b0365 article-title: Chitosan coating of anionic liposomes containing sumatriptan succinate : a candidate for nasal administration publication-title: Nanomed. J. – volume: 146 start-page: 313 year: 2012 ident: 10.1016/j.addr.2021.113826_b0705 article-title: Effects of anatomy and particle size on nasal sprays and nebulizers publication-title: Otolaryngol. - Head Neck Surg. doi: 10.1177/0194599811427519 – volume: 17 start-page: 127 year: 2020 ident: 10.1016/j.addr.2021.113826_b0045 article-title: A consensus research agenda for optimising nasal drug delivery publication-title: Expert Opin. Drug Deliv. doi: 10.1080/17425247.2020.1714589 – volume: 48 year: 2010 ident: 10.1016/j.addr.2021.113826_b0515 article-title: A review of the implications of computational fluid dynamic studies on nasal airflow and physiology publication-title: Rhinol. J. doi: 10.4193/Rhin09.133 – volume: 21 start-page: 435 year: 2013 ident: 10.1016/j.addr.2021.113826_b0235 article-title: Cell-penetrating peptide-modified PLGA nanoparticles for enhanced nose-to-brain macromolecular delivery publication-title: Macromol. Res. doi: 10.1007/s13233-013-1029-2 – volume: 23 start-page: 775 year: 2015 ident: 10.1016/j.addr.2021.113826_b0030 article-title: Nanotechnology-mediated nose to brain drug delivery for Parkinson’s disease: A mini review publication-title: J. Drug Target. doi: 10.3109/1061186X.2015.1020809 – volume: 25 start-page: 290 year: 2020 ident: 10.1016/j.addr.2021.113826_b0260 article-title: Spray-dried alginate microparticles for potential intranasal delivery of ropinirole hydrochloride: development, characterization and histopathological evaluation publication-title: Pharm. Dev. Technol. doi: 10.1080/10837450.2019.1567762 – volume: 9 start-page: 595 year: 2012 ident: 10.1016/j.addr.2021.113826_b0710 article-title: Coaxial electrospray of microparticles and nanoparticles for biomedical applications publication-title: Expert Rev. Med. Devices. doi: 10.1586/erd.12.58 – volume: 4 start-page: 311 year: 1991 ident: 10.1016/j.addr.2021.113826_b1050 article-title: Role of simulated repetitive coughing in mucus clearance publication-title: Eur. Respir. doi: 10.1183/09031936.93.04030311 – volume: 14 start-page: 5895 year: 2019 ident: 10.1016/j.addr.2021.113826_b0090 article-title: S. Ata Ur Rahman, M.I.M. Abdul, M.A. Shaker, Recent expansions of novel strategies towards the drug targeting into the brain publication-title: Int. J. Nanomedicine. doi: 10.2147/IJN.S210876 – volume: 31 start-page: 108 year: 2016 ident: 10.1016/j.addr.2021.113826_b0405 article-title: In vitro, ex vivo and in vivo performance of chitosan-based spray-dried nasal mucoadhesive microspheres of diltiazem hydrochloride publication-title: J. Drug Deliv. Sci. Technol. doi: 10.1016/j.jddst.2015.12.004 – volume: 33 start-page: 1527 year: 2016 ident: 10.1016/j.addr.2021.113826_b0130 article-title: Visualization and Quantification of Nasal and Olfactory Deposition in a Sectional Adult Nasal Airway Cast publication-title: Pharm. Res. doi: 10.1007/s11095-016-1896-2 – volume: 6 start-page: 352 year: 2016 ident: 10.1016/j.addr.2021.113826_b0230 article-title: Nose-to-brain delivery of macromolecules mediated by cell-penetrating peptides publication-title: Acta Pharm. Sin. B. doi: 10.1016/j.apsb.2016.04.001 – volume: 24 start-page: 645 year: 2018 ident: 10.1016/j.addr.2021.113826_b0865 article-title: A review on quality control in additive manufacturing publication-title: Rapid Prototyp. J. doi: 10.1108/RPJ-03-2017-0048 – volume: 106 start-page: 386 year: 2018 ident: 10.1016/j.addr.2021.113826_b1055 article-title: Rheological properties of synthetic mucus for airway clearance: Rheological Properties of Synthetic Mucus publication-title: J. Biomed. Mater. Res. Part A. doi: 10.1002/jbm.a.36251 – volume: 68 start-page: 1028 year: 1979 ident: 10.1016/j.addr.2021.113826_b0250 article-title: Osmolality of parenteral solutions publication-title: J. Pharm. Sci. doi: 10.1002/jps.2600680829 – volume: 579 year: 2020 ident: 10.1016/j.addr.2021.113826_b0360 article-title: Nose to brain delivery of rotigotine loaded chitosan nanoparticles in human SH-SY5Y neuroblastoma cells and animal model of Parkinson’s disease publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2020.119148 – volume: 20 start-page: 408 year: 2020 ident: 10.1016/j.addr.2021.113826_b0980 article-title: Material response characterization of three poly jet printed materials used in a high fidelity human infant skull publication-title: Mater. Today Proc. doi: 10.1016/j.matpr.2019.09.156 – volume: 281 start-page: 139 year: 2018 ident: 10.1016/j.addr.2021.113826_b0035 article-title: Nose-to-brain drug delivery: An update on clinical challenges and progress towards approval of anti-Alzheimer drugs publication-title: J. Control. Release. doi: 10.1016/j.jconrel.2018.05.011 – volume: 185 year: 2020 ident: 10.1016/j.addr.2021.113826_b0270 article-title: In vitro investigations on dopamine loaded Solid Lipid Nanoparticles publication-title: J. Pharm. Biomed. Anal. doi: 10.1016/j.jpba.2020.113257 – volume: 56 start-page: 3 year: 2010 ident: 10.1016/j.addr.2021.113826_b0530 article-title: Is nose-to-brain transport of drugs in man a reality? publication-title: J. Pharm. Pharmacol. doi: 10.1211/0022357022539 – year: 2020 ident: 10.1016/j.addr.2021.113826_b0135 article-title: In vitro – in vivo correlation of intranasal drug deposition publication-title: Adv. Drug Deliv. Rev. – volume: 28 start-page: 962 year: 2011 ident: 10.1016/j.addr.2021.113826_b0200 article-title: Lipophilicity and its relationship with passive drug permeation publication-title: Pharm. Res. doi: 10.1007/s11095-010-0303-7 – volume: 105 start-page: 1209 year: 2016 ident: 10.1016/j.addr.2021.113826_b0805 article-title: Development and Evaluation of a Novel Intranasal Spray for the Delivery of Amantadine publication-title: J. Pharm. Sci. doi: 10.1016/j.xphs.2015.12.016 – volume: 9 year: 2019 ident: 10.1016/j.addr.2021.113826_b0895 article-title: Revealing interactions of layered polymeric materials at solid-liquid interface for building solvent compatibility charts for 3D printing applications publication-title: Sci. Rep. doi: 10.1038/s41598-019-56350-w – volume: 12 start-page: 86 year: 2020 ident: 10.1016/j.addr.2021.113826_b0415 article-title: Zolmitriptan brain targeting via intranasal route using solid lipid nanoparticles for migraine therapy: Formulation, characterization, in-vitro and in-vivo assessment publication-title: Int. J. Appl. Pharm. doi: 10.22159/ijap.2020v12i2.36812 – volume: 44 start-page: 897 year: 2015 ident: 10.1016/j.addr.2021.113826_b0735 article-title: Long-Acting Intranasal Insulin Detemir Improves Cognition for Adults with Mild Cognitive Impairment or Early-Stage Alzheimer’s Disease Dementia publication-title: J. Alzheimer’s Dis. doi: 10.3233/JAD-141791 – volume: 14 start-page: 267 year: 2001 ident: 10.1016/j.addr.2021.113826_b0790 article-title: Characterization of Nasal Spray Pumps and Deposition Pattern in a Replica of the Human Nasal Airway publication-title: J. Aerosol Med. doi: 10.1089/08942680152484199 – volume: 25 start-page: 215 year: 2009 ident: 10.1016/j.addr.2021.113826_b0840 article-title: Management of the Aging Nose publication-title: Facial Plast. Surg. doi: 10.1055/s-0029-1242032 – volume: 36 start-page: 48 year: 2015 ident: 10.1016/j.addr.2021.113826_b0460 article-title: Regional deposition of mometasone furoate nasal spray suspension in humans publication-title: Allergy Asthma Proc. doi: 10.2500/aap.2015.36.3817 – volume: 21 start-page: 1 year: 2021 ident: 10.1016/j.addr.2021.113826_b0915 article-title: Assessment of the reproducibility and precision of milling and 3D printing surgical guides publication-title: BMC Oral Health. doi: 10.1186/s12903-020-01362-6 – volume: 13 start-page: 2102 year: 2018 ident: 10.1016/j.addr.2021.113826_b0040 article-title: Nose-to-brain drug delivery approach: A key to easily accessing the brain for the treatment of Alzheimer’s disease publication-title: Neural Regen. Res. doi: 10.4103/1673-5374.241458 – volume: 49 start-page: 143 year: 2020 ident: 10.1016/j.addr.2021.113826_b0935 article-title: Can an entry-level 3D printer create high-quality anatomical models? Accuracy assessment of mandibular models printed by a desktop 3D printer and a professional device publication-title: Int. J. Oral Maxillofac. Surg. doi: 10.1016/j.ijom.2019.03.962 – volume: 69 start-page: 68 year: 2021 ident: 10.1016/j.addr.2021.113826_b0885 article-title: Geometric precision analysis for Additive Manufacturing processes: A comparative study publication-title: Precis. Eng. doi: 10.1016/j.precisioneng.2020.12.022 – volume: 31 start-page: 228 year: 2014 ident: 10.1016/j.addr.2021.113826_b1000 article-title: Validation of anatomical models to study aerosol deposition in human nasal cavities publication-title: Pharm. Res. doi: 10.1007/s11095-013-1157-6 – volume: 5 start-page: 12 year: 2016 ident: 10.1016/j.addr.2021.113826_b0140 article-title: Pharmaceutical Preformulation Studies in Formulation and Development of New Dosage Form: A Review publication-title: Int. J. Pharma Res. Rev. – volume: 135 start-page: 127 year: 2009 ident: 10.1016/j.addr.2021.113826_b0780 article-title: Development and testing of particulate formulations for the nasal delivery of antibodies publication-title: J. Control. Release. doi: 10.1016/j.jconrel.2008.11.009 – volume: 159 year: 2021 ident: 10.1016/j.addr.2021.113826_b0290 article-title: Mucoadhesive nanostructured lipid carriers as a cannabidiol nasal delivery system for the treatment of neuropathic pain publication-title: Eur. J. Pharm. Sci. doi: 10.1016/j.ejps.2020.105698 – volume: 20 start-page: 495 year: 2007 ident: 10.1016/j.addr.2021.113826_b0765 article-title: The Influence of Spray Properties on Intranasal Deposition publication-title: J. Aerosol Med. doi: 10.1089/jam.2007.0638 – volume: 104 start-page: 1661 year: 2019 ident: 10.1016/j.addr.2021.113826_b0880 article-title: Modelling of the temperature and residual stress fields during 3D printing of polymer composites publication-title: Int. J. Adv. Manuf. Technol. doi: 10.1007/s00170-019-03965-y – volume: 10 start-page: 344 year: 2020 ident: 10.1016/j.addr.2021.113826_b0660 article-title: Brain Targeted Delivery of Rizatriptan using Glutathione Conjugated Liposomes through Transmucosal Nasal Route publication-title: Int. J. Pharm. Investig. doi: 10.5530/ijpi.2020.3.61 – volume: 2 start-page: 41 year: 2019 ident: 10.1016/j.addr.2021.113826_b1065 article-title: Optimization of 3D-printed microstructures for investigating the properties of the mucus biobarrier publication-title: Micro Nano Eng. doi: 10.1016/j.mne.2018.12.004 – volume: 12 start-page: 2559 year: 2017 ident: 10.1016/j.addr.2021.113826_b0970 article-title: Comparison of pulsed versus continuous oxygen delivery using realistic adult nasal airway replicas publication-title: Int. J. Chron. Obstruct. Pulmon. Dis. doi: 10.2147/COPD.S141976 – volume: 577 start-page: 1 year: 2020 ident: 10.1016/j.addr.2021.113826_b0400 article-title: Facile nose-to-brain delivery of rotigotine-loaded polymer micelles thermosensitive hydrogels: In vitro characterization and in vivo behavior study publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2020.119046 – volume: 29 start-page: 13 year: 1998 ident: 10.1016/j.addr.2021.113826_b0525 article-title: Nasal mucociliary clearance as a factor in nasal drug delivery publication-title: Adv. Drug Deliv. Rev. doi: 10.1016/S0169-409X(97)00059-8 – volume: 11 start-page: 1 year: 2000 ident: 10.1016/j.addr.2021.113826_b0065 article-title: Transport of drugs from the nasal cavity to the central nervous system publication-title: Eur. J. Pharm. Sci. doi: 10.1016/S0928-0987(00)00087-7 – volume: 28 start-page: 1895 year: 2011 ident: 10.1016/j.addr.2021.113826_b1020 article-title: Effect of formulation- and administration-related variables on deposition pattern of nasal spray pumps evaluated using a nasal cast publication-title: Pharm. Res. doi: 10.1007/s11095-011-0417-6 – volume: 15 start-page: 167 year: 2001 ident: 10.1016/j.addr.2021.113826_b0095 article-title: Administration intranasale des médicaments pour une action systémique publication-title: La Lett. Du Pharmacol. – volume: 1 start-page: 21 year: 2011 ident: 10.1016/j.addr.2021.113826_b0190 article-title: Advances in nasal trans-mucosal drug delivery publication-title: J. Appl. Pharm. Sci. – volume: 7 start-page: 884 year: 2010 ident: 10.1016/j.addr.2021.113826_b0060 article-title: Trigeminal Pathways Deliver a Low Molecular Weight Drug from the Nose to the Brain and Orofacial Structures publication-title: Mol. Pharm. doi: 10.1021/mp100029t – volume: 98 start-page: 121 year: 2018 ident: 10.1016/j.addr.2021.113826_b0925 article-title: Suitability of 3D-Printed devices for low-temperature geochemical experiments publication-title: Appl. Geochemistry. doi: 10.1016/j.apgeochem.2018.08.012 – volume: 52 start-page: 242 year: 2019 ident: 10.1016/j.addr.2021.113826_b0875 article-title: Innovative Extruder Concept for Fast and Efficient Additive Manufacturing publication-title: IFAC-PapersOnLine. doi: 10.1016/j.ifacol.2019.10.071 – volume: 19 start-page: 58 year: 2012 ident: 10.1016/j.addr.2021.113826_b0470 article-title: Carbamazepine Mucoadhesive Nanoemulgel (MNEG) as brain targeting delivery system via the olfactory mucosa publication-title: Drug Deliv. doi: 10.3109/10717544.2011.644349 – volume: 10 start-page: 1044 year: 2020 ident: 10.1016/j.addr.2021.113826_b0025 article-title: Nose-to-brain delivery: exploring newer domains for glioblastoma multiforme management publication-title: Drug Deliv. Transl. Res. doi: 10.1007/s13346-020-00747-y – volume: 8 start-page: 297 year: 2016 ident: 10.1016/j.addr.2021.113826_b0350 article-title: Preparation, characterisation and colloidal stability of chitosan-tripolyphosphate nanoparticles: Optimisation of formulation and process parameters publication-title: Int. J. Pharm. Pharm. Sci. – volume: 5 year: 2017 ident: 10.1016/j.addr.2021.113826_b0080 article-title: Intranasal Drug Delivery: A Non-Invasive Approach for the Better Delivery of Neurotherapeutics publication-title: Pharm. Nanotechnol. – volume: 46 start-page: 299 year: 2013 ident: 10.1016/j.addr.2021.113826_b0810 article-title: Patient specific CFD models of nasal airflow: Overview of methods and challenges publication-title: J. Biomech. doi: 10.1016/j.jbiomech.2012.11.022 – volume: 16 start-page: 123 year: 2018 ident: 10.1016/j.addr.2021.113826_b0295 article-title: Formulation and Evaluation of Neuroactive Drug Loaded Chitosan Nanoparticle for Nose to Brain Delivery: In-vitro Characterization and In-vivo Behavior Study publication-title: Curr. Drug Deliv. doi: 10.2174/1567201815666181011121750 – volume: 38 start-page: 398 year: 2007 ident: 10.1016/j.addr.2021.113826_b0450 article-title: Modeling of inertial particle transport and deposition in human nasal cavities with wall roughness publication-title: J. Aerosol Sci. doi: 10.1016/j.jaerosci.2007.02.002 – volume: 548 start-page: 305 year: 2018 ident: 10.1016/j.addr.2021.113826_b0440 article-title: A modified USP induction port to characterize nasal spray plume geometry and predict turbinate deposition under flow publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2018.06.058 – volume: 129 start-page: 257 year: 2018 ident: 10.1016/j.addr.2021.113826_b0155 article-title: Chitosan-coated liposome dry-powder formulations loaded with ghrelin for nose-to-brain delivery publication-title: Eur. J. Pharm. Biopharm. doi: 10.1016/j.ejpb.2018.06.011 – volume: 10 start-page: 8 year: 2018 ident: 10.1016/j.addr.2021.113826_b0570 article-title: The role of combined penetration enhancers in nasal microspheres on in vivo drug bioavailability publication-title: Pharmaceutics. doi: 10.3390/pharmaceutics11010008 – volume: 147 start-page: 233 year: 1997 ident: 10.1016/j.addr.2021.113826_b0380 article-title: The influence of tonicity and viscosity on the intranasal absorption of salmon calcitonin in rabbits publication-title: Int. J. Pharm. doi: 10.1016/S0378-5173(96)04817-X – volume: 327 start-page: 235 year: 2020 ident: 10.1016/j.addr.2021.113826_b0625 article-title: Stimuli-responsive In situ gelling system for nose-to-brain drug delivery publication-title: J. Control. Release. doi: 10.1016/j.jconrel.2020.07.044 – volume: 9 start-page: 195 year: 2019 ident: 10.1016/j.addr.2021.113826_b0565 article-title: Current Advances in Chitosan Nanoparticles Based Drug Delivery and Targeting publication-title: Adv. Pharm. Bull. doi: 10.15171/apb.2019.023 – volume: 7 start-page: 1184 year: 2002 ident: 10.1016/j.addr.2021.113826_b0180 article-title: Nasal drug delivery: New developments and strategies publication-title: Drug Discov. Today. doi: 10.1016/S1359-6446(02)02529-1 – volume: 5 start-page: 28 year: 2020 ident: 10.1016/j.addr.2021.113826_b0480 article-title: Nasal vaccine delivery attenuates brain pathology and cognitive impairment in tauopathy model mice publication-title: npj Vaccines doi: 10.1038/s41541-020-0172-y – volume: 3 start-page: 32 year: 2019 ident: 10.1016/j.addr.2021.113826_b1005 article-title: In vitro qualitative and quantitative CT assessment of iodinated aerosol nasal deposition using a 3D-printed nasal replica publication-title: Eur. Radiol. Exp. doi: 10.1186/s41747-019-0113-6 – ident: 10.1016/j.addr.2021.113826_b0010 doi: 10.1016/B978-0-12-819712-7.00015-2 – volume: 11 start-page: 1 year: 2019 ident: 10.1016/j.addr.2021.113826_b0075 article-title: Strategies to enhance drug absorption via nasal and pulmonary routes publication-title: Pharmaceutics. doi: 10.3390/pharmaceutics11030113 – volume: 61 start-page: 75 year: 2009 ident: 10.1016/j.addr.2021.113826_b1045 article-title: Barrier properties of mucus publication-title: Adv. Drug Deliv. Rev. doi: 10.1016/j.addr.2008.09.008 – volume: 114 start-page: 197 year: 1995 ident: 10.1016/j.addr.2021.113826_b0375 article-title: Effects of formulation variables on nasal epithelial cell integrity: Biochemical evaluations publication-title: Int. J. Pharm. doi: 10.1016/0378-5173(94)00238-Z – volume: 21 start-page: 1 year: 2020 ident: 10.1016/j.addr.2021.113826_b0420 article-title: Liposome consolidated with cyclodextrin provides prolonged drug retention resulting in increased drug bioavailability in brain publication-title: Int. J. Mol. Sci. – volume: 13 year: 2018 ident: 10.1016/j.addr.2021.113826_b0900 article-title: Improvement of quality of 3D printed objects by elimination of microscopic structural defects in fused deposition modeling publication-title: PLoS ONE doi: 10.1371/journal.pone.0198370 – volume: 8 start-page: 19 year: 2013 ident: 10.1016/j.addr.2021.113826_b0905 article-title: Multiple material additive manufacturing – Part 1: a review publication-title: Virtual Phys. Prototyp. doi: 10.1080/17452759.2013.778175 – volume: 162 start-page: 194 year: 2012 ident: 10.1016/j.addr.2021.113826_b0600 article-title: CriticalSorbTM: A novel efficient nasal delivery system for human growth hormone based on Solutol HS15 publication-title: J. Control. Release. doi: 10.1016/j.jconrel.2012.06.014 – volume: 28 start-page: 20 year: 2015 ident: 10.1016/j.addr.2021.113826_b0055 article-title: Experimental Measurements and Computational Predictions of Regional Particle Deposition in a Sectional Nasal Model publication-title: J. Aerosol Med. Pulm. Drug Deliv. doi: 10.1089/jamp.2013.1084 – volume: 9 start-page: 1 year: 2016 ident: 10.1016/j.addr.2021.113826_b1070 article-title: Effects of the surface physico-chemical properties and the surface textures on the initial colonization and the attached growth in algal biofilm publication-title: Biotechnol. Biofuels. doi: 10.1186/s13068-016-0451-z – ident: 10.1016/j.addr.2021.113826_b1010 – volume: 268 start-page: 364 year: 2017 ident: 10.1016/j.addr.2021.113826_b0745 article-title: Progress in brain targeting drug delivery system by nasal route publication-title: J. Control. Release. doi: 10.1016/j.jconrel.2017.09.001 – volume: 33 start-page: 923 year: 2002 ident: 10.1016/j.addr.2021.113826_b1015 article-title: The influence of breathing patterns on particle deposition in a nasal replicate cast publication-title: J. Aerosol Sci. doi: 10.1016/S0021-8502(02)00044-7 – volume: 13 start-page: 1 year: 2020 ident: 10.1016/j.addr.2021.113826_b0675 article-title: Liquid crystalline nanoparticles for nasal delivery of rosuvastatin: Implications on therapeutic efficacy in management of epilepsy publication-title: Pharmaceuticals. doi: 10.3390/ph13110356 – ident: 10.1016/j.addr.2021.113826_b0005 doi: 10.1016/B978-0-12-814487-9.00007-7 – volume: 42 start-page: 100 year: 2011 ident: 10.1016/j.addr.2021.113826_b0685 article-title: Simulation of sprayed particle deposition in a human nasal cavity including a nasal spray device publication-title: J. Aerosol Sci. doi: 10.1016/j.jaerosci.2010.11.008 – volume: 3 start-page: 299 year: 2013 ident: 10.1016/j.addr.2021.113826_b0825 article-title: The aerodynamics of the sinonasal interface: the nose takes wing-a paradigm shift for our time publication-title: Int. Forum Allergy Rhinol. doi: 10.1002/alr.21105 – volume: 105 start-page: 1995 year: 2016 ident: 10.1016/j.addr.2021.113826_b0245 article-title: Linking Suspension Nasal Spray Drug Deposition Patterns to Pharmacokinetic Profiles: A Proof-of-Concept Study Using Computational Fluid Dynamics publication-title: J. Pharm. Sci. doi: 10.1016/j.xphs.2016.03.033 – volume: 32 start-page: 77 year: 2016 ident: 10.1016/j.addr.2021.113826_b0545 article-title: Particulate formulations based on chitosan for nose-to-brain delivery of drugs. A review publication-title: J. Drug Deliv Sci. Technol. doi: 10.1016/j.jddst.2015.05.002 – volume: 107 start-page: 206 year: 2019 ident: 10.1016/j.addr.2021.113826_b0770 article-title: An idealized geometry that mimics average nasal spray deposition in adults: A computational study publication-title: Comput. Biol. Med. doi: 10.1016/j.compbiomed.2019.02.013 – volume: 38 start-page: 713 year: 2008 ident: 10.1016/j.addr.2021.113826_b0680 article-title: Optimising nasal spray parameters for efficient drug delivery using computational fluid dynamics publication-title: Comput. Biol. Med. doi: 10.1016/j.compbiomed.2008.03.008 – year: 2021 ident: 10.1016/j.addr.2021.113826_b0330 article-title: Stability of lyophilized and spray dried vaccine formulations publication-title: Adv. Drug Deliv. Rev. doi: 10.1016/j.addr.2021.01.016 – volume: 550 start-page: 35 year: 2018 ident: 10.1016/j.addr.2021.113826_b0340 article-title: Spray dried cubosomes with ovalbumin and Quil-A as a nanoparticulate dry powder vaccine formulation publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2018.08.036 – volume: 24 start-page: 557 year: 1987 ident: 10.1016/j.addr.2021.113826_b1060 article-title: Rheological properties controlling mucociliary frequency and respiratory mucus transport publication-title: Biorheology. doi: 10.3233/BIR-1987-24606 – volume: 56 start-page: 730 year: 2007 ident: 10.1016/j.addr.2021.113826_b0800 article-title: Consolidation phenomena in laser and powder-bed based layered manufacturing publication-title: CIRP Ann. - Manuf. Technol. doi: 10.1016/j.cirp.2007.10.004 – volume: 42 start-page: 52 year: 2011 ident: 10.1016/j.addr.2021.113826_b0965 article-title: Effects of surface smoothness on inertial particle deposition in human nasal models publication-title: J. Aerosol Sci. doi: 10.1016/j.jaerosci.2010.11.002 – volume: 12 start-page: 1 year: 2020 ident: 10.1016/j.addr.2021.113826_b0650 article-title: Double optimization of rivastigmine-loaded nanostructured lipid carriers (NLC) for nose-to-brain delivery using the quality by design (QbD) approach: Formulation variables and instrumental parameters publication-title: Pharmaceutics. doi: 10.3390/pharmaceutics12070599 – volume: 46 start-page: 1161 year: 2008 ident: 10.1016/j.addr.2021.113826_b0815 article-title: Numerical flow simulation in the post-endoscopic sinus surgery nasal cavity publication-title: Med. Biol. Eng. Comput. doi: 10.1007/s11517-008-0384-1 – volume: 17 start-page: 839 year: 2020 ident: 10.1016/j.addr.2021.113826_b0185 article-title: Nose-to-brain delivery of antipsychotics using nanotechnology: a review publication-title: Expert Opin. Drug Deliv. doi: 10.1080/17425247.2020.1762563 – volume: 10 start-page: 1 year: 2018 ident: 10.1016/j.addr.2021.113826_b0085 article-title: A review on strategies for improving nasal drug delivery systems publication-title: Drug Invent. Today. – volume: 13 start-page: 125 year: 2012 ident: 10.1016/j.addr.2021.113826_b0170 article-title: Duloxetine HCl lipid nanoparticles: Preparation, characterization, and dosage form design publication-title: AAPS PharmSciTech. doi: 10.1208/s12249-011-9727-6 – ident: 10.1016/j.addr.2021.113826_b0395 – volume: 574 year: 2020 ident: 10.1016/j.addr.2021.113826_b0785 article-title: Impact of physicochemical properties of nasal spray products on drug deposition and transport in the pediatric nasal cavity model publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2019.118911 – volume: 379 start-page: 144 year: 2021 ident: 10.1016/j.addr.2021.113826_b0500 article-title: Microfluidic spray dried and spray freeze dried uniform microparticles potentially for intranasal drug delivery and controlled release publication-title: Powder Technol. doi: 10.1016/j.powtec.2020.10.061 – volume: 42 start-page: 74 year: 2019 ident: 10.1016/j.addr.2021.113826_b0590 article-title: Quantitative determination of beta-cyclodextrin in a powder insulin formulation for nasal delivery using hydrophilic interaction chromatography with evaporative light scattering detection publication-title: J. Liq. Chromatogr. Relat. Technol. doi: 10.1080/10826076.2019.1571508 – volume: 3 start-page: 42 year: 2013 ident: 10.1016/j.addr.2021.113826_b0750 article-title: Nasal drug delivery devices: characteristics and performance in a clinical perspective—a review publication-title: Drug Deliv. Transl. Res. doi: 10.1007/s13346-012-0108-9 – volume: 570 year: 2019 ident: 10.1016/j.addr.2021.113826_b0070 article-title: Strategies to facilitate or block nose-to-brain drug delivery publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2019.118635 – volume: 529 start-page: 523 year: 2017 ident: 10.1016/j.addr.2021.113826_b0985 article-title: 3D printing of tablets using inkjet with UV photoinitiation publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2017.06.085 – volume: 105 year: 2019 ident: 10.1016/j.addr.2021.113826_b0695 article-title: Electrospray for generation of drug delivery and vaccine particles applied in vitro and in vivo publication-title: Mater. Sci. Eng. C. doi: 10.1016/j.msec.2019.110070 – volume: 10 start-page: 279 year: 2020 ident: 10.1016/j.addr.2021.113826_b0285 article-title: Design and Development of Chitosan Beta-cyclodextrin based Nasal Mucoadhesive Microspheres of Clarithromycin publication-title: Int. J. Pharm. Investig. doi: 10.5530/ijpi.2020.3.51 – volume: 19 start-page: 468 year: 2011 ident: 10.1016/j.addr.2021.113826_b0345 article-title: Brain targeting of risperidone-loaded solid lipid nanoparticles by intranasal route publication-title: J. Drug Target. doi: 10.3109/1061186X.2010.523787 – volume: 2 start-page: 4 year: 1996 ident: 10.1016/j.addr.2021.113826_b0795 article-title: Structural quality of parts processed by fused deposition publication-title: Rapid Prototyp. J. doi: 10.1108/13552549610732034 – volume: 307 start-page: 76 year: 2019 ident: 10.1016/j.addr.2021.113826_b0410 article-title: Nose-to-brain delivery of hyaluronate – FG loop peptide conjugate for non-invasive hypoxic-ischemic encephalopathy therapy publication-title: J. Control. Release. doi: 10.1016/j.jconrel.2019.06.021 – volume: 1726 year: 2020 ident: 10.1016/j.addr.2021.113826_b0655 article-title: Pharmacokinetics, pharmacodynamics and toxicity of Baicalin liposome on cerebral ischemia reperfusion injury rats via intranasal administration publication-title: Brain Res. doi: 10.1016/j.brainres.2019.146503 – volume: 164 start-page: 799 year: 1949 ident: 10.1016/j.addr.2021.113826_b1035 article-title: Mixture law for viscosity [21] publication-title: Nature doi: 10.1038/164799b0 – volume: 499 start-page: 376 year: 2016 ident: 10.1016/j.addr.2021.113826_b0860 article-title: 3D printing in pharmaceutics: A new tool for designing customized drug delivery systems publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2015.12.071 – volume: 48 start-page: 930 year: 2014 ident: 10.1016/j.addr.2021.113826_b0445 article-title: A Comparison of the Deposition Patterns of Different Nasal Spray Formulations Using a Nasal Cast publication-title: Aerosol Sci. Technol. doi: 10.1080/02786826.2014.931566 – volume: 76 start-page: 535 year: 1987 ident: 10.1016/j.addr.2021.113826_b0240 article-title: Analysis of Structural Requirements for the Absorption of Drugs and Macromolecules from the Nasal Cavity publication-title: J. Pharm. Sci. doi: 10.1002/jps.2600760709 – volume: 25 start-page: 558 year: 2000 ident: 10.1016/j.addr.2021.113826_b0390 article-title: The effect of hypertonicity on nasal mucociliary clearance publication-title: Clin. Otolaryngol. Allied Sci. doi: 10.1046/j.1365-2273.2000.00420.x – volume: 9 start-page: 19 year: 2012 ident: 10.1016/j.addr.2021.113826_b0205 article-title: Physicochemical and physiological considerations for efficient nose-to-brain targeting publication-title: Expert Opin. Drug Deliv. doi: 10.1517/17425247.2012.636801 – volume: 17 start-page: 182 year: 2016 ident: 10.1016/j.addr.2021.113826_b0870 article-title: Three-Dimensional Printing: Basic Principles and Applications in Medicine and Radiology publication-title: Korean J. Radiol. doi: 10.3348/kjr.2016.17.2.182 – volume: 35 start-page: 357 year: 2018 ident: 10.1016/j.addr.2021.113826_b0335 article-title: A comparative study of stabilising effect and antioxidant activity of different antioxidants on levodopa-loaded liposomes publication-title: J. Microencapsul. doi: 10.1080/02652048.2018.1487473 – volume: 25 start-page: 185 year: 2020 ident: 10.1016/j.addr.2021.113826_b0020 article-title: Nose-to-brain delivery of antiglioblastoma drugs embedded into lipid nanocarrier systems: status quo and outlook publication-title: Drug Discov. Today. doi: 10.1016/j.drudis.2019.10.005 – volume: 292 start-page: 111 year: 2018 ident: 10.1016/j.addr.2021.113826_b0325 article-title: Intranasal immunization with aluminum salt-adjuvanted dry powder vaccine publication-title: J. Control. Release. doi: 10.1016/j.jconrel.2018.10.020 – volume: 148 start-page: 38 year: 2020 ident: 10.1016/j.addr.2021.113826_b0640 article-title: Progress and perspectives of brain-targeting lipid-based nanosystems via the nasal route in Alzheimer’s disease publication-title: Eur. J. Pharm. Biopharm. doi: 10.1016/j.ejpb.2019.12.014 – volume: 86 start-page: 18 year: 2017 ident: 10.1016/j.addr.2021.113826_b1025 article-title: Numerical study on the air conditioning characteristics of the human nasal cavity publication-title: Comput. Biol. Med. doi: 10.1016/j.compbiomed.2017.04.018 – volume: 302 start-page: 140 year: 2019 ident: 10.1016/j.addr.2021.113826_b0125 article-title: Characterisation of nasal devices for delivery of insulin to the brain and evaluation in humans using functional magnetic resonance imaging publication-title: J. Control. Release. doi: 10.1016/j.jconrel.2019.03.032 – volume: 25 start-page: 280 year: 2012 ident: 10.1016/j.addr.2021.113826_b0760 article-title: Nasal deposition and clearance in man: Comparison of a bidirectional powder device and a traditional liquid spray pump publication-title: J. Aerosol Med. Pulm. Drug Deliv. doi: 10.1089/jamp.2011.0924 – volume: 22 start-page: 206 year: 2007 ident: 10.1016/j.addr.2021.113826_b0430 article-title: Influence of formulation viscosity on drug absorption following nasal application in rats publication-title: Drug Metab. Pharmacokinet. doi: 10.2133/dmpk.22.206 – volume: 27 start-page: 984 year: 2019 ident: 10.1016/j.addr.2021.113826_b0495 article-title: Anti-inflammatory flurbiprofen nasal powders for nose-to-brain delivery in Alzheimer’s disease publication-title: J. Drug Target. doi: 10.1080/1061186X.2019.1574300 – volume: 30 start-page: 118 year: 2017 ident: 10.1016/j.addr.2021.113826_b0725 article-title: Nasal and Olfactory Deposition with Normal and Bidirectional Intranasal Delivery Techniques. In Vitro Tests and Numerical Simulations, J. Aerosol Med. Pulm publication-title: Drug Deliv. – volume: 99 start-page: 1745 year: 2010 ident: 10.1016/j.addr.2021.113826_b0475 article-title: Brain delivery of proteins by the intranasal route of administration: A comparison of cationic liposomes versus aqueous solution formulations publication-title: J. Pharm. Sci. doi: 10.1002/jps.21939 – volume: 13 start-page: 34 year: 2017 ident: 10.1016/j.addr.2021.113826_b0620 article-title: Current prospects and future challenges for nasal vaccine delivery publication-title: Hum. Vaccines Immunother. doi: 10.1080/21645515.2016.1239668 – volume: 27 start-page: 21 year: 2014 ident: 10.1016/j.addr.2021.113826_b0115 article-title: Design of Experiments to Optimize an In Vitro Cast to Predict Human Nasal Drug Deposition publication-title: J. Aerosol Med. Pulm. Drug Deliv. doi: 10.1089/jamp.2012.1011 – volume: 2 start-page: 1391 year: 2011 ident: 10.1016/j.addr.2021.113826_b0150 article-title: Pharmaceutical Preformulation Studies – Current Review publication-title: Int. J. Pharm. Biol. Arch. – volume: 113 start-page: 2 year: 2018 ident: 10.1016/j.addr.2021.113826_b0605 article-title: Opportunity and challenges of nasal powders: Drug formulation and delivery publication-title: Eur. J. Pharm. Sci. doi: 10.1016/j.ejps.2017.09.027 – ident: 10.1016/j.addr.2021.113826_b0715 doi: 10.1007/978-1-4614-7978-9_5 – volume: 7 start-page: 967 year: 2002 ident: 10.1016/j.addr.2021.113826_b0195 article-title: Permeability issues in nasal drug delivery publication-title: Drug Discov. Today. doi: 10.1016/S1359-6446(02)02452-2 – volume: 131 start-page: 5 year: 2021 ident: 10.1016/j.addr.2021.113826_b0975 article-title: Olfactory Cleft Width and Volume: Possible Risk Factors for Postinfectious Olfactory Dysfunction publication-title: Laryngoscope. doi: 10.1002/lary.28524 – volume: 213 start-page: 187 year: 2001 ident: 10.1016/j.addr.2021.113826_b0385 article-title: In situ nasal absorption of midazolam in rats publication-title: Int. J. Pharm. doi: 10.1016/S0378-5173(00)00668-2 – volume: 538 start-page: 223 year: 2018 ident: 10.1016/j.addr.2021.113826_b0995 article-title: 3D extrusion printing of high drug loading immediate release paracetamol tablets publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2018.01.024 – volume: 29 start-page: 153 year: 2016 ident: 10.1016/j.addr.2021.113826_b0830 article-title: A Computational Study of Nasal Spray Deposition Pattern in Four Ethnic Groups publication-title: J. Aerosol Med. Pulm. Drug Deliv. doi: 10.1089/jamp.2014.1205 – volume: 14 year: 2019 ident: 10.1016/j.addr.2021.113826_b0455 article-title: Nasal sprayed particle deposition in a human nasal cavity under different inhalation conditions publication-title: PLoS ONE doi: 10.1371/journal.pone.0221330 – volume: 256 start-page: 237 year: 2014 ident: 10.1016/j.addr.2021.113826_b0510 article-title: High resolution SEM imaging of gold nanoparticles in cells and tissues publication-title: J. Microsc. doi: 10.1111/jmi.12179 – volume: 34 start-page: 423 year: 2019 ident: 10.1016/j.addr.2021.113826_b0355 article-title: Curcumin loaded TPGS micelles for nose to brain drug delivery: in vitro and in vivo studies publication-title: Mater. Technol. doi: 10.1080/10667857.2019.1575535 – volume: 29 start-page: 264 year: 2019 ident: 10.1016/j.addr.2021.113826_b0370 article-title: Nanostructured cubosomes in an in situ nasal gel system: an alternative approach for the controlled delivery of donepezil HCl to brain publication-title: J. Liposome Res. doi: 10.1080/08982104.2018.1552703 – volume: 35 year: 2018 ident: 10.1016/j.addr.2021.113826_b0110 article-title: In Vitro Assessment of Spray Deposition Patterns in a Pediatric (12 Year-Old) Nasal Cavity Model publication-title: Pharm. Res. doi: 10.1007/s11095-018-2385-6 – volume: 109 start-page: 2237 year: 2020 ident: 10.1016/j.addr.2021.113826_b0220 article-title: Coated Lipidic Nanoparticles as a New Strategy for Enhancing Nose-to-Brain Delivery of a Hydrophilic Drug Molecule publication-title: J. Pharm. Sci. doi: 10.1016/j.xphs.2020.04.007 – volume: 77 start-page: 40 year: 2016 ident: 10.1016/j.addr.2021.113826_b0690 article-title: Effects of nasal drug delivery device and its orientation on sprayed particle deposition in a realistic human nasal cavity publication-title: Comput. Biol. Med. doi: 10.1016/j.compbiomed.2016.08.002 – volume: 124 start-page: 3 year: 2018 ident: 10.1016/j.addr.2021.113826_b0960 article-title: The biology of mucus: Composition, synthesis and organization publication-title: Adv. Drug Deliv. Rev. doi: 10.1016/j.addr.2017.09.023 – volume: 559 start-page: 86 year: 2019 ident: 10.1016/j.addr.2021.113826_b0635 article-title: Updates on thermosensitive hydrogel for nasal, ocular and cutaneous delivery publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2019.01.030 – volume: 8 start-page: 54 year: 2020 ident: 10.1016/j.addr.2021.113826_b0940 article-title: Trends in Selective Laser Sintering in Biomedical Engineering publication-title: Int. J. Emerg. Trends Eng. Res. doi: 10.30534/ijeter/2020/10812020 – volume: 11 start-page: 485 year: 2020 ident: 10.1016/j.addr.2021.113826_b1030 article-title: Role of nasal casts for in vitro evaluation of nasal drug delivery and quantitative evaluation of various nasal casts publication-title: Ther. Deliv. doi: 10.4155/tde-2020-0054 – year: 2010 ident: 10.1016/j.addr.2021.113826_b0160 publication-title: Biotechnology: Pharmaceutical Aspects – volume: 130 start-page: 433 year: 2017 ident: 10.1016/j.addr.2021.113826_b0300 article-title: Compatibility study between antiparkinsonian drug Levodopa and excipients by FTIR spectroscopy, X-ray diffraction and thermal analysis publication-title: J. Therm. Anal. Calorim. doi: 10.1007/s10973-017-6393-2 – volume: 42 start-page: 1107 year: 2003 ident: 10.1016/j.addr.2021.113826_b0595 article-title: Absorption Enhancers for Nasal Drug Delivery publication-title: Clin. Pharmacokinet. doi: 10.2165/00003088-200342130-00003 – volume: 117 year: 2020 ident: 10.1016/j.addr.2021.113826_b0835 article-title: The effect of nasal shape on the thermal conditioning of inhaled air: Using clinical tomographic data to build a large-scale statistical shape model publication-title: Comput. Biol. Med. doi: 10.1016/j.compbiomed.2020.103600 – volume: 24 start-page: 116 year: 2020 ident: 10.1016/j.addr.2021.113826_b0560 article-title: The dry powder formulation of mixed cross-linked dextran microspheres and tetanus toxoid-loaded trimethyl chitosan nanospheres as a potent adjuvant for nasal delivery system publication-title: Iran. J. Basic Med. Sci. – volume: 70 start-page: 367 year: 2020 ident: 10.1016/j.addr.2021.113826_b0555 article-title: Development of Nasal Mucoadhesive Microspheres of Granisetron: A Potential Drug publication-title: Drug Res. (Stuttg) doi: 10.1055/a-1193-4781 – volume: 106 start-page: 386 year: 2018 ident: 10.1016/j.addr.2021.113826_b1040 article-title: Rheological properties of synthetic mucus for airway clearance publication-title: J. Biomed. Mater. Res. - Part A. doi: 10.1002/jbm.a.36251 – volume: 15 start-page: 5113 year: 2020 ident: 10.1016/j.addr.2021.113826_b0670 article-title: Nanosized cubosomal thermogelling dispersion loaded with saquinavir mesylate to improve its bioavailability: Preparation, optimization, in vitro and in vivo evaluation publication-title: Int. J. Nanomedicine. doi: 10.2147/IJN.S261855 – year: 2021 ident: 10.1016/j.addr.2021.113826_b0265 article-title: Nose to brain delivery of Rotigotine loaded solid lipid nanoparticles: Quality by Design based optimization and characterization publication-title: J. Drug Deliv Sci. Technol. doi: 10.1016/j.jddst.2021.102377 – volume: 8 start-page: 169 year: 2019 ident: 10.1016/j.addr.2021.113826_b0015 article-title: Nasal drug delivery system: A innovative approach, ~ 169 ~ Pharma Innov publication-title: J. – volume: 3 start-page: 131 year: 2015 ident: 10.1016/j.addr.2021.113826_b0225 article-title: pKa-critical interpretations of solubility-pH Profiles: PG-300995 and NSC-639829 case studies publication-title: ADMET DMPK. doi: 10.5599/admet.3.2.182 – ident: 10.1016/j.addr.2021.113826_b0425 doi: 10.1016/j.jconrel.2006.12.014 – volume: 222 start-page: 1013 year: 2008 ident: 10.1016/j.addr.2021.113826_b0105 article-title: Development of a nasal cast model to test medicinal nasal devices publication-title: Proc. Inst. Mech. Eng. Part H J. Eng. Med. doi: 10.1243/09544119JEIM423 – volume: 119 start-page: 1730 year: 2009 ident: 10.1016/j.addr.2021.113826_b0100 article-title: Assessment of septal deviation effects on nasal air flow: A computational fluid dynamics model: Nasal Air Flow with Septal Deviation publication-title: Laryngoscope. doi: 10.1002/lary.20585 – volume: 4 start-page: 210 year: 2020 ident: 10.1016/j.addr.2021.113826_b0700 article-title: Effects of a Coflowing Air on the Characteristics of an Electrospray publication-title: Aerosol Sci. Eng. doi: 10.1007/s41810-020-00068-0 – volume: 12 year: 2020 ident: 10.1016/j.addr.2021.113826_b0520 article-title: Spray dried formulations for inhalation—meaningful characterisation of powder properties publication-title: Pharmaceutics. – volume: 34 year: 2018 ident: 10.1016/j.addr.2021.113826_b0465 article-title: Regional deposition of nasal sprays in adults: A wide ranging computational study publication-title: Int. j. Numer. Method. Biomed. Eng. doi: 10.1002/cnm.2968 – volume: 431 start-page: 138 year: 2012 ident: 10.1016/j.addr.2021.113826_b0165 article-title: Clotrimazole nanoemulsion for malaria chemotherapy. Part I: Preformulation studies, formulation design and physicochemical evaluation publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2011.12.040 – volume: 27 start-page: 394 year: 2015 ident: 10.1016/j.addr.2021.113826_b0615 article-title: Olfactory deposition of inhaled nanoparticles in humans publication-title: Inhal. Toxicol. doi: 10.3109/08958378.2015.1066904 – volume: 16 start-page: 25 year: 2020 ident: 10.1016/j.addr.2021.113826_b0740 article-title: The Upper Nasal Space—A Novel Delivery Route Ideal for Central Nervous System Drugs publication-title: US Neurol. doi: 10.17925/USN.2020.16.1.25 – volume: 9 year: 2018 ident: 10.1016/j.addr.2021.113826_b0920 article-title: Highly fluorinated methacrylates for optical 3D printing of microfluidic devices publication-title: Micromachines. doi: 10.3390/mi9030115 – volume: 25 start-page: 735 year: 2020 ident: 10.1016/j.addr.2021.113826_b0310 article-title: In vitro and in vivo evaluation of levodopa-loaded nanoparticles for nose to brain delivery publication-title: Pharm. Dev. Technol. doi: 10.1080/10837450.2020.1740257 |
| SSID | ssj0012760 |
| Score | 2.5241632 |
| SecondaryResourceType | review_article |
| Snippet | [Display omitted]
•A framework to develop nose-to-brain drugs combining pharmaceutics and engineering.•The importance of the pre-formulation for safe, stable... This review aims to cement three hot topics in drug delivery: (a) the pre-formulation of new products intended for nose-to-brain delivery; (b) the development... |
| SourceID | proquest pubmed crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 113826 |
| SubjectTerms | 3D printing Administration devices Administration, Intranasal - methods Animals Brain - drug effects Brain Diseases - drug therapy Drug Compounding - methods Formulation properties Humans Nasal casts Nasal Cavity - anatomy & histology Nose-to-brain Olfactory region Pre-formulation studies Printing, Three-Dimensional Treatment effectiveness |
| Title | The importance of pre-formulation studies and of 3D-printed nasal casts in the success of a pharmaceutical product intended for nose-to-brain delivery |
| URI | https://dx.doi.org/10.1016/j.addr.2021.113826 https://www.ncbi.nlm.nih.gov/pubmed/34119575 https://www.proquest.com/docview/2540718765 |
| Volume | 175 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELaqIiQuqJTX8qgGCfVCza4Tx3GOVaFaQFSVaKW9WXZii0UlWTXZw174GfxeZuJkCxL0wDHJWLEzTzsz3zD2Gu1droIIKLxCcZl4izpXSG4L4YW3uBGyVI38-UzNL-XHRbbYYSdjLQylVQ62P9r03loPd6bD15yulsvpF8IRwd3JIiEUUaGoolzKnKT87Y9tmodI8r5SmIg5UQ-FMzHHC5WbMEETQa1NNAEs_N05_Sv47J3Q6R67P0SPcBwn-IDt-Hqf3Y39JDf77PA8AlFvjuDipq6qPYJDOL-BqN48ZD_xMSy_97E3rhiaAJQOQgHs0M4L2phgCLau6HH6jtMRIManUNsW51DatmthWQNGkNCu-76LRGhh9fX3Y3JYRUxZoMF03A74Fqib1vOu4Y46VEDlryg9ZPOIXZ6-vziZ86FDAy9R9zvuS-mCKHRa4U7IFlqL1BaOUNolclqhdZA-SbRDi6pDZq3TWpUqC06mYWbzKn3Mduum9k8ZzJysnHah1BU6VhySzkKOsatOUqRWasLEyBpTDvDl1EXjyox5at8MsdMQO01k54S92Y5ZRfCOW6mzkePmDxE06F1uHfdqFA-Dukk_XGztm3Vrkh7dEP1NNmFPotxs54GLFAXGys_-863P2T26irmIL9hud732LzE-6txBrwAH7M7xh0_zs1-2Iw85 |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9swDCa6FMN6Gbbu0ax7cMDQy2ok8lM-Ft2KdG2DAkuB3ATJlrEUrR3MziF_ZL-3pGWnG7D1sGskwnIokp9k8iPAJ_J3SVyIgjaviL3Qt5psLg09nQorrKaDkOZq5ItpPLkKv82j-RYc97UwnFbZ-X7n01tv3f0y6v7N0XKxGH1nHhE6ncx9ZhEVcfIItpmdKhrA9tHp2WS6-ZjgJ22xMM_3WKCrnXFpXmTfTAvqC-5uIplj4e_x6V_4s41DJ8_gaQcg8cit8Tls2XIXHruWkutdOLh0XNTrQ5zdl1bVh3iAl_cs1esX8IuGcXHbwm96aawK5IwQxrBdRy-sXY4h6jLn4eCLx7eABFGx1DWtIdN1U-OiRAKRWK_a1os8UePyx-835bh0tLLIwnzjjvQULKvaek3lGW5Sgbm94QyR9Uu4Ovk6O554XZMGLyPzbzybhaYQqQxyOgzpVEoR6NQwUXtIyo7JQYTW96UhpyqLSGsjZZzFUWHCoBjrJA9ewaCsSrsHODZhbqQpMplTbCWRYFwkBF-lH9DsOB6C6FWjso7BnBtp3Kg-Ve1asToVq1M5dQ7h80Zm6fg7Hpwd9RpXf-xCRQHmQbmP_fZQZJ78zUWXtlrVym8JDinkREN47fbNZh30kiIluPzmP5_6AZ5MZhfn6vx0erYPOzziUhPfwqD5ubLvCC415n1nDnf0xBHq |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+importance+of+pre-formulation+studies+and+of+3D-printed+nasal+casts+in+the+success+of+a+pharmaceutical+product+intended+for+nose-to-brain+delivery&rft.jtitle=Advanced+drug+delivery+reviews&rft.au=Deruyver%2C+Laura&rft.au=Rigaut%2C+Cl%C3%A9ment&rft.au=Lambert%2C+Pierre&rft.au=Haut%2C+Beno%C3%AEt&rft.date=2021-08-01&rft.issn=0169-409X&rft.volume=175&rft.spage=113826&rft_id=info:doi/10.1016%2Fj.addr.2021.113826&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_j_addr_2021_113826 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0169-409X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0169-409X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0169-409X&client=summon |