Antiprotease therapy in cancer: hot or not?

• Published in: Expert opinion on biological therapy Vol. 6; no. 3; p. 257
• Main Authors: Lah, Tamara T, Durán Alonso, María Beatriz, Van Noorden, Cornelis J F
• Format: Journal Article
• Language: English
• Published: England 01.03.2006
• Subjects: Animals; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Humans; Neoplasm Invasiveness - genetics; Neoplasm Invasiveness - prevention & control; Neoplasms - drug therapy; Neoplasms - genetics; Neoplasms - metabolism; Peptide Hydrolases - genetics; Peptide Hydrolases - metabolism; Protease Inhibitors - pharmacology; Protease Inhibitors - therapeutic use

The activity of a set of peptidases (proteases) involved in cancer progression is collectively known as the cancer 'degradome'. Invasion and metastasis were initially considered as late events in cancer development and the processes in which proteases were involved. However, recent studies...