Serum- and Glucocorticoid-Inducible Kinase 1 Sensitive NF-κB Signaling in Dendritic Cells

• Published in: Cellular physiology and biochemistry Vol. 34; no. 3; pp. 943 - 954
• Main Authors: Schmid, Evi, Xuan, Nguyen Thi, Zahir, Naima, Russo, Antonella, Yang, Wenting, Kuhl, Dietmar, Faggio, Caterina, Shumilina, Ekaterina, Lang, Florian
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland Cell Physiol Biochem Press GmbH & Co KG 01.01.2014
• Subjects: Animals; Base Sequence; Cell Cycle Proteins - metabolism; Cell Differentiation; Dendritic Cells - enzymology; Dendritic Cells - immunology; Dendritic Cells - metabolism; DNA Primers; IKKα/β; Immediate-Early Proteins - metabolism; Intracellular Signaling Peptides and Proteins - metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; NDRG1; NF-kappa B - metabolism; NF-κB; Original Paper; Phagocytosis; Phosphorylation; PI3 kinase; Protein-Serine-Threonine Kinases - metabolism; Real-Time Polymerase Chain Reaction; Up-Regulation; NF-κB; IKKα/β; PI3 kinase; NDRG1; Phagocytosis

Background/Aims: Dendritic cells (DCs), antigen-presenting cells linking innate and adaptive immunity, are required for initiation of specific T cell-driven immune responses. Phosphoinositide-3-kinase (PI3K) suppresses proinflammatory cytokine production in DCs, which limits T helper (Th1) polarizat...