Attenuation of histamine-induced airway effects by intranasal application of levocetirizine in mice

• Published in: Immunopharmacology and immunotoxicology Vol. 35; no. 5; pp. 545 - 548
• Main Authors: Kitayama-Sugiyama, Chie, Mochizuki, Naoko, Murata, Hitomi, Katsura, Masashi, Kamei, Chiaki
• Format: Journal Article
• Language: English
• Published: England Informa Healthcare USA, Inc 01.10.2013; Taylor & Francis
• Subjects: Administration, Intranasal; Animals; Cetirizine; Cetirizine - pharmacology; Dose-Response Relationship, Drug; histamine; Histamine - adverse effects; Histamine - pharmacology; Histamine H1 Antagonists, Non-Sedating - pharmacology; Humans; levocetirizine; Male; Mice; nasal rubbing; Receptors, Histamine H1 - metabolism; sneezing; Sneezing - drug effects

Abstract The present study was performed to investigate the histamine-induced airway effect of levocetirizine, an active enantiomer of cetirizine, by intranasal application using ddY mice. Nasal rubbing and sneezing after histamine application into the nasal cavity were used as an index of histamine...