The Cardiovascular Biology of Glucagon-like Peptide-1

• Published in: Cell metabolism Vol. 24; no. 1; pp. 15 - 30
• Main Author: Drucker, Daniel J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 12.07.2016
• Subjects: Animals; Cardiovascular System - metabolism; Clinical Trials as Topic; Glucagon-Like Peptide 1 - metabolism; Humans; Inflammation - metabolism; Inflammation - pathology; Models, Biological; Signal Transduction

Glucagon-like peptide-1, produced predominantly in enteroendocrine cells, controls glucose metabolism and energy homeostasis through regulation of islet hormone secretion, gastrointestinal motility, and food intake, enabling development of GLP-1 receptor (GLP-1R) agonists for the treatment of diabet...