Locomotor Dysfunction and Pain: The Scylla and Charybdis of Fiber Sprouting After Spinal Cord Injury

• Published in: Molecular neurobiology Vol. 37; no. 1; pp. 52 - 63
• Main Authors: Deumens, Ronald, Joosten, Elbert A. J., Waxman, Stephen G., Hains, Bryan C.
• Format: Journal Article
• Language: English
• Published: New York Humana Press Inc 01.02.2008; Springer Nature B.V
• Subjects: Afferent Pathways - pathology; Afferent Pathways - physiopathology; Animals; Biomedical and Life Sciences; Biomedicine; Cell Biology; Charybdis; Chronic Disease; Gait Disorders, Neurologic - etiology; Gait Disorders, Neurologic - physiopathology; Humans; Nerve Regeneration; Neurobiology; Neurology; Neuronal Plasticity; Neurosciences; Nociceptors - pathology; Nociceptors - physiopathology; Pain; Pain - etiology; Pain - physiopathology; Recovery of Function; Scylla; Spinal cord injuries; Spinal Cord Injuries - complications; Spinal Cord Injuries - physiopathology; Spinal Nerve Roots - pathology; Spinal Nerve Roots - physiopathology; Studies; Primary afferents; Pain; Sprouting; Spinal cord injury; Hyperexcitability

Injury to the spinal cord (SCI) can produce a constellation of problems including chronic pain, autonomic dysreflexia, and motor dysfunction. Neuroplasticity in the form of fiber sprouting or the lack thereof is an important phenomenon that can contribute to the deleterious effects of SCI. Aberrant...