Metformin pharmacokinetics in nondiabetic pregnant women with polycystic ovary syndrome

• Published in: European journal of clinical pharmacology Vol. 67; no. 10; pp. 1027 - 1033
• Main Authors: de Oliveira Baraldi, Cláudia, Lanchote, Vera Lucia, de Jesus Antunes, Natalícia, de Jesus Ponte Carvalho, Teresa Maria, Dantes Moisés, Elaine Christine, Duarte, Geraldo, Cavalli, Ricardo Carvalho
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.10.2011; Springer; Springer Nature B.V
• Subjects: Adolescent; Adult; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Drug therapy; Female; Female genital diseases; Fetal Blood; Gynecology. Andrology. Obstetrics; Humans; Hypoglycemic Agents - adverse effects; Hypoglycemic Agents - blood; Hypoglycemic Agents - pharmacokinetics; Hypoglycemic Agents - therapeutic use; Maternal-Fetal Exchange - drug effects; Medical sciences; Metformin - adverse effects; Metformin - blood; Metformin - pharmacokinetics; Metformin - therapeutic use; Non tumoral diseases; Pharmacokinetics and Disposition; Pharmacology; Pharmacology. Drug treatments; Pharmacology/Toxicology; Polycystic ovary syndrome; Polycystic Ovary Syndrome - drug therapy; Polycystic Ovary Syndrome - metabolism; Pregnancy; Pregnancy Complications, Neoplastic - drug therapy; Pregnancy Complications, Neoplastic - metabolism; Pregnancy Trimester, Third - drug effects; Young Adult; Pregnancy; Polycystic ovary syndrome; Metformin; Pharmacokinetics; Human; Female sterility; Polycystic ovary; Female genital diseases; Ovarian diseases; Hypoglycemic agent; Biguanides; Cyst; Adult; Female; Benign neoplasm; Woman

Background The use of metformin throughout gestation by pregnant women with polycystic ovary syndrome (PCOS) significantly reduces the number of first trimester spontaneous abortions and the rate of occurrence of gestational diabetes. Objective The objective of this study was to investigate the phar...