Ionic silver-infused peroxidase-like metal-organic frameworks as versatile "antibiotic" for enhanced bacterial elimination
The fabrication of multiple antibacterial modalities for combating bacterial pathogens and treating infected wounds is of vital importance. Accordingly, nanozymes have emerged as a new generation of "antibiotics" with broad-spectrum antibacterial potency and high stability; however, the fu...
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| Published in | Nanoscale Vol. 12; no. 3; pp. 1633 - 16338 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Royal Society of Chemistry
14.08.2020
|
| Subjects | |
| Online Access | Get full text |
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| Abstract | The fabrication of multiple antibacterial modalities for combating bacterial pathogens and treating infected wounds is of vital importance. Accordingly, nanozymes have emerged as a new generation of "antibiotics" with broad-spectrum antibacterial potency and high stability; however, the further application of nanozymes in clinical medicine is still limited by their single-modal antibacterial process, which cannot eradicate bacteria totally. Herein, we infused the NH
2
-MIL-88B(Fe) peroxidase-like nanomaterial with a small amount of Ag(
i
) to construct NH
2
-MIL-88B(Fe)-Ag, a potent and benign "antibiotic" with the ability to eliminate bacteria completely. This versatile system could efficiently convert H
2
O
2
into the more toxic &z.rad;OH and release Ag(
i
) simultaneously, making pathogenic bacteria more vulnerable to be eliminated, which decreased the requirement for the toxic H
2
O
2
and high concentration of Ag(
i
). More importantly, the
in vivo
results indicated that the synergistic germicidal system could be used for wound disinfection successfully with excellent antibacterial efficacy and negligible biotoxicity. This strategy paves the way for the development of integrated antibacterial agents with enhanced antibacterial function and alternative antibiotics.
A biocompatible ionic silver-metal organic framework composite with intrinsic peroxidase-like activity is successfully constructed for combating bacterial infection. |
|---|---|
| AbstractList | The fabrication of multiple antibacterial modalities for combating bacterial pathogens and treating infected wounds is of vital importance. Accordingly, nanozymes have emerged as a new generation of "antibiotics" with broad-spectrum antibacterial potency and high stability; however, the further application of nanozymes in clinical medicine is still limited by their single-modal antibacterial process, which cannot eradicate bacteria totally. Herein, we infused the NH2-MIL-88B(Fe) peroxidase-like nanomaterial with a small amount of Ag(i) to construct NH2-MIL-88B(Fe)-Ag, a potent and benign "antibiotic" with the ability to eliminate bacteria completely. This versatile system could efficiently convert H2O2 into the more toxic ˙OH and release Ag(i) simultaneously, making pathogenic bacteria more vulnerable to be eliminated, which decreased the requirement for the toxic H2O2 and high concentration of Ag(i). More importantly, the in vivo results indicated that the synergistic germicidal system could be used for wound disinfection successfully with excellent antibacterial efficacy and negligible biotoxicity. This strategy paves the way for the development of integrated antibacterial agents with enhanced antibacterial function and alternative antibiotics.The fabrication of multiple antibacterial modalities for combating bacterial pathogens and treating infected wounds is of vital importance. Accordingly, nanozymes have emerged as a new generation of "antibiotics" with broad-spectrum antibacterial potency and high stability; however, the further application of nanozymes in clinical medicine is still limited by their single-modal antibacterial process, which cannot eradicate bacteria totally. Herein, we infused the NH2-MIL-88B(Fe) peroxidase-like nanomaterial with a small amount of Ag(i) to construct NH2-MIL-88B(Fe)-Ag, a potent and benign "antibiotic" with the ability to eliminate bacteria completely. This versatile system could efficiently convert H2O2 into the more toxic ˙OH and release Ag(i) simultaneously, making pathogenic bacteria more vulnerable to be eliminated, which decreased the requirement for the toxic H2O2 and high concentration of Ag(i). More importantly, the in vivo results indicated that the synergistic germicidal system could be used for wound disinfection successfully with excellent antibacterial efficacy and negligible biotoxicity. This strategy paves the way for the development of integrated antibacterial agents with enhanced antibacterial function and alternative antibiotics. The fabrication of multiple antibacterial modalities for combating bacterial pathogens and treating infected wounds is of vital importance. Accordingly, nanozymes have emerged as a new generation of "antibiotics" with broad-spectrum antibacterial potency and high stability; however, the further application of nanozymes in clinical medicine is still limited by their single-modal antibacterial process, which cannot eradicate bacteria totally. Herein, we infused the NH -MIL-88B(Fe) peroxidase-like nanomaterial with a small amount of Ag(i) to construct NH -MIL-88B(Fe)-Ag, a potent and benign "antibiotic" with the ability to eliminate bacteria completely. This versatile system could efficiently convert H O into the more toxic ˙OH and release Ag(i) simultaneously, making pathogenic bacteria more vulnerable to be eliminated, which decreased the requirement for the toxic H O and high concentration of Ag(i). More importantly, the in vivo results indicated that the synergistic germicidal system could be used for wound disinfection successfully with excellent antibacterial efficacy and negligible biotoxicity. This strategy paves the way for the development of integrated antibacterial agents with enhanced antibacterial function and alternative antibiotics. The fabrication of multiple antibacterial modalities for combating bacterial pathogens and treating infected wounds is of vital importance. Accordingly, nanozymes have emerged as a new generation of "antibiotics" with broad-spectrum antibacterial potency and high stability; however, the further application of nanozymes in clinical medicine is still limited by their single-modal antibacterial process, which cannot eradicate bacteria totally. Herein, we infused the NH 2 -MIL-88B(Fe) peroxidase-like nanomaterial with a small amount of Ag( i ) to construct NH 2 -MIL-88B(Fe)-Ag, a potent and benign "antibiotic" with the ability to eliminate bacteria completely. This versatile system could efficiently convert H 2 O 2 into the more toxic &z.rad;OH and release Ag( i ) simultaneously, making pathogenic bacteria more vulnerable to be eliminated, which decreased the requirement for the toxic H 2 O 2 and high concentration of Ag( i ). More importantly, the in vivo results indicated that the synergistic germicidal system could be used for wound disinfection successfully with excellent antibacterial efficacy and negligible biotoxicity. This strategy paves the way for the development of integrated antibacterial agents with enhanced antibacterial function and alternative antibiotics. A biocompatible ionic silver-metal organic framework composite with intrinsic peroxidase-like activity is successfully constructed for combating bacterial infection. The fabrication of multiple antibacterial modalities for combating bacterial pathogens and treating infected wounds is of vital importance. Accordingly, nanozymes have emerged as a new generation of “antibiotics” with broad-spectrum antibacterial potency and high stability; however, the further application of nanozymes in clinical medicine is still limited by their single-modal antibacterial process, which cannot eradicate bacteria totally. Herein, we infused the NH2-MIL-88B(Fe) peroxidase-like nanomaterial with a small amount of Ag(i) to construct NH2-MIL-88B(Fe)-Ag, a potent and benign “antibiotic” with the ability to eliminate bacteria completely. This versatile system could efficiently convert H2O2 into the more toxic ·OH and release Ag(i) simultaneously, making pathogenic bacteria more vulnerable to be eliminated, which decreased the requirement for the toxic H2O2 and high concentration of Ag(i). More importantly, the in vivo results indicated that the synergistic germicidal system could be used for wound disinfection successfully with excellent antibacterial efficacy and negligible biotoxicity. This strategy paves the way for the development of integrated antibacterial agents with enhanced antibacterial function and alternative antibiotics. The fabrication of multiple antibacterial modalities for combating bacterial pathogens and treating infected wounds is of vital importance. Accordingly, nanozymes have emerged as a new generation of “antibiotics” with broad-spectrum antibacterial potency and high stability; however, the further application of nanozymes in clinical medicine is still limited by their single-modal antibacterial process, which cannot eradicate bacteria totally. Herein, we infused the NH 2 -MIL-88B(Fe) peroxidase-like nanomaterial with a small amount of Ag( i ) to construct NH 2 -MIL-88B(Fe)-Ag, a potent and benign “antibiotic” with the ability to eliminate bacteria completely. This versatile system could efficiently convert H 2 O 2 into the more toxic ˙OH and release Ag( i ) simultaneously, making pathogenic bacteria more vulnerable to be eliminated, which decreased the requirement for the toxic H 2 O 2 and high concentration of Ag( i ). More importantly, the in vivo results indicated that the synergistic germicidal system could be used for wound disinfection successfully with excellent antibacterial efficacy and negligible biotoxicity. This strategy paves the way for the development of integrated antibacterial agents with enhanced antibacterial function and alternative antibiotics. |
| Author | Ren, Xinyi Li, Min Liu, Lizhi Yue, Tianli Wang, Jianlong Han, Ximei Sun, Jing Zhang, Wentao Shi, Shuo Zhu, Wenxin |
| AuthorAffiliation | Chinese Academy of Sciences University of Eastern Finland Qinghai Provincial Key Laboratory of Qinghai-Tibet Plateau Biological Resources College of Food Science and Engineering Department of Applied Physics Northwest A&F University Northwest Institute of Plateau Biology |
| AuthorAffiliation_xml | – name: Northwest Institute of Plateau Biology – name: Northwest A&F University – name: University of Eastern Finland – name: Department of Applied Physics – name: Chinese Academy of Sciences – name: Qinghai Provincial Key Laboratory of Qinghai-Tibet Plateau Biological Resources – name: College of Food Science and Engineering |
| Author_xml | – sequence: 1 givenname: Wentao surname: Zhang fullname: Zhang, Wentao – sequence: 2 givenname: Xinyi surname: Ren fullname: Ren, Xinyi – sequence: 3 givenname: Shuo surname: Shi fullname: Shi, Shuo – sequence: 4 givenname: Min surname: Li fullname: Li, Min – sequence: 5 givenname: Lizhi surname: Liu fullname: Liu, Lizhi – sequence: 6 givenname: Ximei surname: Han fullname: Han, Ximei – sequence: 7 givenname: Wenxin surname: Zhu fullname: Zhu, Wenxin – sequence: 8 givenname: Tianli surname: Yue fullname: Yue, Tianli – sequence: 9 givenname: Jing surname: Sun fullname: Sun, Jing – sequence: 10 givenname: Jianlong surname: Wang fullname: Wang, Jianlong |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32724949$$D View this record in MEDLINE/PubMed |
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| Notes | Electronic supplementary information (ESI) available: Supporting figures (Fig. S1-S9) and Tables (S1 and S2). See DOI 10.1039/d0nr01471k ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
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| SubjectTerms | Anti-Bacterial Agents - pharmacology Antibiotics Antiinfectives and antibacterials Bacteria Biocompatibility Clinical medicine Hydrogen Peroxide Metal-Organic Frameworks Nanomaterials Peroxidase Peroxidases Silver |
| Title | Ionic silver-infused peroxidase-like metal-organic frameworks as versatile "antibiotic" for enhanced bacterial elimination |
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