Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease

• Published in: Cell metabolism Vol. 33; no. 11; pp. 2260 - 2276.e7
• Main Authors: Erny, Daniel, Dokalis, Nikolaos, Mezö, Charlotte, Castoldi, Angela, Mossad, Omar, Staszewski, Ori, Frosch, Maximilian, Villa, Matteo, Fuchs, Vidmante, Mayer, Arun, Neuber, Jana, Sosat, Janika, Tholen, Stefan, Schilling, Oliver, Vlachos, Andreas, Blank, Thomas, Gomez de Agüero, Mercedes, Macpherson, Andrew J., Pearce, Edward J., Prinz, Marco
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 02.11.2021
• Subjects: acetate; Acetates - pharmacology; Alzheimer’s disease; Animals; Brain - metabolism; Fatty Acids, Volatile - metabolism; germ-free; Immune System - metabolism; metabolism; Mice; microbiota; Microbiota - physiology; microglia; mitochondria; respiratory chain; SCFA; germ-free; microbiota; acetate; Alzheimer’s disease; mitochondria; metabolism; microglia; SCFA; respiratory chain

As tissue macrophages of the central nervous system (CNS), microglia constitute the pivotal immune cells of this organ. Microglial features are strongly dependent on environmental cues such as commensal microbiota. Gut bacteria are known to continuously modulate microglia maturation and function by...