Methionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming

• Published in: Cell metabolism Vol. 31; no. 2; pp. 250 - 266.e9
• Main Authors: Roy, Dominic G., Chen, Jocelyn, Mamane, Victoria, Ma, Eric H., Muhire, Brejnev M., Sheldon, Ryan D., Shorstova, Tatiana, Koning, Rutger, Johnson, Radia M., Esaulova, Ekaterina, Williams, Kelsey S., Hayes, Sebastian, Steadman, Mya, Samborska, Bozena, Swain, Amanda, Daigneault, Audrey, Chubukov, Victor, Roddy, Thomas P., Foulkes, William, Pospisilik, J. Andrew, Bourgeois-Daigneault, Marie-Claude, Artyomov, Maxim N., Witcher, Michael, Krawczyk, Connie M., Larochelle, Catherine, Jones, Russell G.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 04.02.2020
• Subjects: Animals; Cell Proliferation; Cytokines - metabolism; Disease Models, Animal; EAE; Encephalomyelitis, Autoimmune, Experimental - drug therapy; Encephalomyelitis, Autoimmune, Experimental - metabolism; Epigenesis, Genetic - drug effects; HEK293 Cells; histone methylation; Histones - metabolism; Humans; inflammation; metabolism; methionine; Methionine - metabolism; Methionine - pharmacology; Methylation; Mice, Inbred C57BL; Mice, Knockout; Multiple Sclerosis - drug therapy; Multiple Sclerosis - metabolism; SAM; T cells; Th17 cells; Th17 Cells - cytology; Th17 Cells - metabolism; histone methylation; methionine; inflammation; EAE; metabolism; T cells; SAM; Th17 cells

Epigenetic modifications on DNA and histones regulate gene expression by modulating chromatin accessibility to transcription machinery. Here we identify methionine as a key nutrient affecting epigenetic reprogramming in CD4+ T helper (Th) cells. Using metabolomics, we showed that methionine is rapid...