Association of Qi-stagnation constitution and subjective sleep characteristics with mild cognitive impairment among elderly in community: A cross-sectional study
Depression and sleep disturbance are commonly reported in patients with mild cognitive impairment (MCI). However, it remains unclear whether Qi-stagnation constitution is a risk factor for MCI before older adults suffer from depression. Subjects were recruited from 34 community elderly day care cent...
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| Published in | European journal of integrative medicine Vol. 59; p. 102232 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Elsevier GmbH
01.04.2023
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1876-3820 1876-3839 |
| DOI | 10.1016/j.eujim.2023.102232 |
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| Abstract | Depression and sleep disturbance are commonly reported in patients with mild cognitive impairment (MCI). However, it remains unclear whether Qi-stagnation constitution is a risk factor for MCI before older adults suffer from depression.
Subjects were recruited from 34 community elderly day care centers in China. Intensive face-to-face interviews were conducted using Montreal cognitive function assessment, AD8 dementia screening questionnaire, Pittsburgh Sleep Quality Index (PSQI), and Traditional Chinese medicine constitution assessment scale. Multi-factor logistical regression was employed to analyze the association among subjective sleep quality, TCM constitution, and MCI.
A total of 1,071 cases were analyzed in this study, including 314 patients with MCI. The probability of those with Qi-deficiency and Qi-stagnation suffering from MCI was 1.559 times and 1.706 times higher than that of the older adults without Qi-deficiency and Qi-stagnation, respectively (P<0.05). In the PSQI scale, individuals with MCI had poorer subjective sleep quality, longer sleep latency, shorter sleep duration, and aggravated daytime dysfunction (P<0.05) compared with those without MCI. The results of multi-factor logistical regression showed that sleep latency (OR=1.168), daytime dysfunction (OR=1.261), and Qi-stagnation (OR=1.449) were risk factors for MCI; the OR of suffering from MCI in the elderly with sleep disturbance and Qi-stagnation was 2.581. (all P<0.05).
MCI patients have a higher prevalence of sleep disorders and Qi-stagnation, and may show specific changes in their daytime and nighttime sleep characteristics, with the specific manifestations such as difficulty in falling asleep, easily waking up at night/ early morning, and daytime dysfunction, among others.
Chinese Clinical Trial Registry ChiCTR2000039411 |
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| AbstractList | Depression and sleep disturbance are commonly reported in patients with mild cognitive impairment (MCI). However, it remains unclear whether Qi-stagnation constitution is a risk factor for MCI before older adults suffer from depression.
Subjects were recruited from 34 community elderly day care centers in China. Intensive face-to-face interviews were conducted using Montreal cognitive function assessment, AD8 dementia screening questionnaire, Pittsburgh Sleep Quality Index (PSQI), and Traditional Chinese medicine constitution assessment scale. Multi-factor logistical regression was employed to analyze the association among subjective sleep quality, TCM constitution, and MCI.
A total of 1,071 cases were analyzed in this study, including 314 patients with MCI. The probability of those with Qi-deficiency and Qi-stagnation suffering from MCI was 1.559 times and 1.706 times higher than that of the older adults without Qi-deficiency and Qi-stagnation, respectively (P<0.05). In the PSQI scale, individuals with MCI had poorer subjective sleep quality, longer sleep latency, shorter sleep duration, and aggravated daytime dysfunction (P<0.05) compared with those without MCI. The results of multi-factor logistical regression showed that sleep latency (OR=1.168), daytime dysfunction (OR=1.261), and Qi-stagnation (OR=1.449) were risk factors for MCI; the OR of suffering from MCI in the elderly with sleep disturbance and Qi-stagnation was 2.581. (all P<0.05).
MCI patients have a higher prevalence of sleep disorders and Qi-stagnation, and may show specific changes in their daytime and nighttime sleep characteristics, with the specific manifestations such as difficulty in falling asleep, easily waking up at night/ early morning, and daytime dysfunction, among others.
Chinese Clinical Trial Registry ChiCTR2000039411 |
| ArticleNumber | 102232 |
| Author | Wu, Jingsong Tu, Jingnan He, Youze Liu, Zhizhen Cao, Lei Tao, Jing Chen, Lidian Huang, Jia |
| Author_xml | – sequence: 1 givenname: Zhizhen orcidid: 0000-0002-4594-0325 surname: Liu fullname: Liu, Zhizhen email: lzz@fjtcm.edu.cn organization: National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China – sequence: 2 givenname: Lei surname: Cao fullname: Cao, Lei organization: College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China – sequence: 3 givenname: Jingsong surname: Wu fullname: Wu, Jingsong organization: College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China – sequence: 4 givenname: Youze surname: He fullname: He, Youze organization: College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China – sequence: 5 givenname: Jingnan surname: Tu fullname: Tu, Jingnan organization: College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China – sequence: 6 givenname: Jia surname: Huang fullname: Huang, Jia organization: College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China – sequence: 7 givenname: Jing surname: Tao fullname: Tao, Jing email: taojing01@fjtcm.edu.cn organization: National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China – sequence: 8 givenname: Lidian surname: Chen fullname: Chen, Lidian email: cld@fjtcm.edu.cn organization: National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China |
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| Keywords | Traditional chinese medicine constitution MCI Sleep AD MoCA GDS-15 Aged Cognitive dysfunction PSQI TCM |
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