Population pharmacokinetics of carvedilol enantiomers and their metabolites in healthy subjects and type-2 diabetes patients - Nardotto, Glauco H.B.; Lanchote, Vera L.; Coelho, Eduardo B.; Della Pasqua, Oscar (European journal of pharmaceutical sciences, 2017)
Keywords: Adrenergic beta-Antagonists - administration & dosage; Adrenergic beta-Antagonists - metabolism; Adrenergic beta-Antagonists - pharmacokinetics; Adult; Blood Glucose - drug effects; Blood Glucose - metabolism; Carbazoles - administration & dosage; Carbazoles - metabolism; Carbazoles - pharmacokinetics; Carvedilol; Cytochrome P-450 CYP2C9 - metabolism; Cytochrome P-450 CYP2C9 Inhibitors - administration & dosage; Cytochrome P-450 CYP2D6 - metabolism; Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - metabolism; Enantiomers; Female; Glyburide - administration & dosage; Healthy Volunteers; Humans; Hypoglycemic Agents - administration & dosage; Male; Metformin - administration & dosage; Middle Aged; Population pharmacokinetics; Propanolamines - administration & dosage; Propanolamines - metabolism; Propanolamines - pharmacokinetics; Stereoisomerism; Stereoselective metabolism; Type 2 diabetes; Type 2 diabetes; Population pharmacokinetics; Stereoselective metabolism; Enantiomers; Carvedilol