GPR56, a Novel Secretin-like Human G-Protein-Coupled Receptor Gene

• Published in: Genomics (San Diego, Calif.) Vol. 55; no. 3; pp. 296 - 305
• Main Authors: Liu, Marjorie, Parker, Rachel M.C., Darby, Karen, Eyre, Helen J., Copeland, Neal G., Crawford, Joanna, Gilbert, Debra J., Sutherland, Grant R., Jenkins, Nancy A., Herzog, Herbert
• Format: Journal Article
• Language: English
• Published: San Diego, CA Elsevier Inc 01.02.1999; Elsevier
• Subjects: Amino Acid Sequence; Animals; Base Sequence; Biological and medical sciences; Blotting, Northern; Chromosome Mapping; Chromosomes, Human, Pair 16 - genetics; Crosses, Genetic; DNA Primers; Exons; Fundamental and applied biological sciences. Psychology; Gene Library; Genes. Genome; GTP-Binding Proteins - genetics; Humans; Hypothalamus - cytology; Hypothalamus - ultrastructure; In Situ Hybridization; In Situ Hybridization, Fluorescence; Introns; Metaphase; Mice; Mice, Inbred C57BL; Models, Biological; Molecular and cellular biology; Molecular genetics; Molecular Sequence Data; Myocardium - cytology; Myocardium - metabolism; Myocardium - ultrastructure; Rats; Receptors, Cell Surface - genetics; Receptors, G-Protein-Coupled; Secretin - genetics; Thyroid Gland - cytology; Thyroid Gland - metabolism; Tissue Distribution; Genetic mapping; Human; Nucleotide sequence; Rodentia; Tissue specificity; Homology; Gene organization; Secretin; Gene expression; Vertebrata; Membrane receptor; Mammalia; Chromosome E16; Complementary DNA; Mouse; Domain structure; Chromosome 8; G protein

A novel gene product, GPR56, with homology to the seven transmembrane-domain receptor superfamily, has been cloned by PCR amplification using degenerate oligonucleotide primers and subsequent screening of a human heart cDNA library. The isolated 2.8-kb cDNA clone encodes a protein of 693 amino acids...