Surface activation of medical grade polyurethane for the covalent immobilization of an anti-adhesive biopolymeric coating

Hospital-acquired infections are still a major concern worldwide, being frequently related to bacterial biofilm formation on medical devices, and thus difficult to eradicate with conventional antimicrobial treatments. Therefore, infection-preventive solutions based on natural polymers are being inve...

Full description

Saved in:
Bibliographic Details
Published inJournal of materials chemistry. B, Materials for biology and medicine Vol. 9; no. 17; pp. 375 - 3715
Main Authors Matinha-Cardoso, Jorge, Mota, Rita, Gomes, Luciana C, Gomes, Marisa, Mergulhão, Filipe J, Tamagnini, Paula, Martins, M. Cristina L, Costa, Fabíola
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 05.05.2021
Subjects
Antibiotics
Antiinfectives and antibacterials
Argon
Bacteria
Biodegradation
Biofilms
Coatings
Contact angle
E coli
Etiology
Immobilization
Industrial applications
Infections
Medical equipment
Natural polymers
Nitrogen plasma
Nosocomial infections
Ozone
Photomicrographs
Polymer coatings
Polymers
Polyurethane
Polyurethane resins
Public health
Substrates
Surface activation
Urinary tract
Urogenital system
Online AccessGet full text

Cover

Abstract Hospital-acquired infections are still a major concern worldwide, being frequently related to bacterial biofilm formation on medical devices, and thus difficult to eradicate with conventional antimicrobial treatments. Therefore, infection-preventive solutions based on natural polymers are being investigated. Recently, a marine cyanobacterium-derived polymeric coating (CyanoCoating) has demonstrated great anti-adhesive potential when immobilized onto gold model substrates. In this work, we took this technology a step closer to an industrial application by covalently immobilizing CyanoCoating onto medical grade polyurethane (PU). This immobilization was developed through the introduction of linkable moieties onto a PU inert surface using different pre-treatments. Besides the application of the polydopamine (pDA) linker layer, other processes frequently found in industrial settings, such as atmospheric plasma (using O 2 or N 2 as reactive gases) and ozone surface activations, were evaluated. From all the pre-treatments tested, the ozone activation was the most promising since the obtained coating not only revealed a homogeneous distribution, but also significantly reduced the adhesion of two relevant etiological bacteria in static conditions (the Gram-positive Staphylococcus aureus and the Gram-negative Escherichia coli ). Moreover, it also impaired E. coli biofilm formation under simulated urinary tract dynamic conditions, reinforcing the potential of CyanoCoating as an antibiotic-free alternative to mitigate medical device-associated infections, particularly in the urinary tract. Evaluation of the surface activation of medical grade polyurethane through different processes towards the covalent immobilization of an anti-adhesive biopolymeric coating.
AbstractList Hospital-acquired infections are still a major concern worldwide, being frequently related to bacterial biofilm formation on medical devices, and thus difficult to eradicate with conventional antimicrobial treatments. Therefore, infection-preventive solutions based on natural polymers are being investigated. Recently, a marine cyanobacterium-derived polymeric coating (CyanoCoating) has demonstrated great anti-adhesive potential when immobilized onto gold model substrates. In this work, we took this technology a step closer to an industrial application by covalently immobilizing CyanoCoating onto medical grade polyurethane (PU). This immobilization was developed through the introduction of linkable moieties onto a PU inert surface using different pre-treatments. Besides the application of the polydopamine (pDA) linker layer, other processes frequently found in industrial settings, such as atmospheric plasma (using O 2 or N 2 as reactive gases) and ozone surface activations, were evaluated. From all the pre-treatments tested, the ozone activation was the most promising since the obtained coating not only revealed a homogeneous distribution, but also significantly reduced the adhesion of two relevant etiological bacteria in static conditions (the Gram-positive Staphylococcus aureus and the Gram-negative Escherichia coli ). Moreover, it also impaired E. coli biofilm formation under simulated urinary tract dynamic conditions, reinforcing the potential of CyanoCoating as an antibiotic-free alternative to mitigate medical device-associated infections, particularly in the urinary tract.
Hospital-acquired infections are still a major concern worldwide, being frequently related to bacterial biofilm formation on medical devices, and thus difficult to eradicate with conventional antimicrobial treatments. Therefore, infection-preventive solutions based on natural polymers are being investigated. Recently, a marine cyanobacterium-derived polymeric coating (CyanoCoating) has demonstrated great anti-adhesive potential when immobilized onto gold model substrates. In this work, we took this technology a step closer to an industrial application by covalently immobilizing CyanoCoating onto medical grade polyurethane (PU). This immobilization was developed through the introduction of linkable moieties onto a PU inert surface using different pre-treatments. Besides the application of the polydopamine (pDA) linker layer, other processes frequently found in industrial settings, such as atmospheric plasma (using O2 or N2 as reactive gases) and ozone surface activations, were evaluated. From all the pre-treatments tested, the ozone activation was the most promising since the obtained coating not only revealed a homogeneous distribution, but also significantly reduced the adhesion of two relevant etiological bacteria in static conditions (the Gram-positive Staphylococcus aureus and the Gram-negative Escherichia coli). Moreover, it also impaired E. coli biofilm formation under simulated urinary tract dynamic conditions, reinforcing the potential of CyanoCoating as an antibiotic-free alternative to mitigate medical device-associated infections, particularly in the urinary tract.
Hospital-acquired infections are still a major concern worldwide, being frequently related to bacterial biofilm formation on medical devices, and thus difficult to eradicate with conventional antimicrobial treatments. Therefore, infection-preventive solutions based on natural polymers are being investigated. Recently, a marine cyanobacterium-derived polymeric coating (CyanoCoating) has demonstrated great anti-adhesive potential when immobilized onto gold model substrates. In this work, we took this technology a step closer to an industrial application by covalently immobilizing CyanoCoating onto medical grade polyurethane (PU). This immobilization was developed through the introduction of linkable moieties onto a PU inert surface using different pre-treatments. Besides the application of the polydopamine (pDA) linker layer, other processes frequently found in industrial settings, such as atmospheric plasma (using O 2 or N 2 as reactive gases) and ozone surface activations, were evaluated. From all the pre-treatments tested, the ozone activation was the most promising since the obtained coating not only revealed a homogeneous distribution, but also significantly reduced the adhesion of two relevant etiological bacteria in static conditions (the Gram-positive Staphylococcus aureus and the Gram-negative Escherichia coli ). Moreover, it also impaired E. coli biofilm formation under simulated urinary tract dynamic conditions, reinforcing the potential of CyanoCoating as an antibiotic-free alternative to mitigate medical device-associated infections, particularly in the urinary tract. Evaluation of the surface activation of medical grade polyurethane through different processes towards the covalent immobilization of an anti-adhesive biopolymeric coating.
Author Mota, Rita
Gomes, Marisa
Costa, Fabíola
Matinha-Cardoso, Jorge
Mergulhão, Filipe J
Gomes, Luciana C
Tamagnini, Paula
Martins, M. Cristina L
AuthorAffiliation Universidade do Porto
Departamento de Biologia
ICBAS - Instituto de Ciências Biomédicas Abel Salazar
Rua Jorge de Viterbo Ferreira 228
Faculty of Engineering
Faculdade de Ciências
University of Porto
i3S - Instituto de Investigação e Inovação em Saúde
LEPABE - Laboratory for Process Engineering, Environment, Biotechnology and Energy
INEB - Instituto de Engenharia Biomédica
IBMC - Instituto de Biologia Celular e Molecular
Rua do Campo Alegre
AuthorAffiliation_xml – name: Universidade do Porto
– name: Faculty of Engineering
– name: LEPABE - Laboratory for Process Engineering, Environment, Biotechnology and Energy
– name: University of Porto
– name: INEB - Instituto de Engenharia Biomédica
– name: i3S - Instituto de Investigação e Inovação em Saúde
– name: Faculdade de Ciências
– name: Rua Jorge de Viterbo Ferreira 228
– name: Departamento de Biologia
– name: Rua do Campo Alegre
– name: IBMC - Instituto de Biologia Celular e Molecular
– name: ICBAS - Instituto de Ciências Biomédicas Abel Salazar
Author_xml – sequence: 1
  givenname: Jorge
  surname: Matinha-Cardoso
  fullname: Matinha-Cardoso, Jorge
– sequence: 2
  givenname: Rita
  surname: Mota
  fullname: Mota, Rita
– sequence: 3
  givenname: Luciana C
  surname: Gomes
  fullname: Gomes, Luciana C
– sequence: 4
  givenname: Marisa
  surname: Gomes
  fullname: Gomes, Marisa
– sequence: 5
  givenname: Filipe J
  surname: Mergulhão
  fullname: Mergulhão, Filipe J
– sequence: 6
  givenname: Paula
  surname: Tamagnini
  fullname: Tamagnini, Paula
– sequence: 7
  givenname: M. Cristina L
  surname: Martins
  fullname: Martins, M. Cristina L
– sequence: 8
  givenname: Fabíola
  surname: Costa
  fullname: Costa, Fabíola
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33871523$$D View this record in MEDLINE/PubMed
BookMark eNpdkU1LxDAQhoMofqxevCsBLyKsJk3TtEddP0HwoIK3kiYTN9I2a5IurL_e6OoKDsNkIM-8ZPLuoPXe9YDQPiWnlLDqTNPYEJKJUq2h7YxwMhacluurnrxsob0Q3kiKkhYlyzfRFmOloDxj22jxOHgjFWCpop3LaF2PncEdaKtki1-91IBnrl0MHuJU9oCN8zhOASs3ly30Eduuc41t7cdqWvYpox1LPYVg54Ab6740OvBWpcEE9q-7aMPINsDezzlCz9dXT5Pb8f3Dzd3k_H6sckJiqhURJdesAaGhklwXOldNDqWhwsimkFRok1HOecWqqgKqBBiadtIKiixnI3S81J159z5AiHVng4K2Tcu4IdQZp5wIXhU8oUf_0Dc3-D69LlFZRmgiSaJOlpTyLgQPpp5520m_qCmpvzypL-nTxbcnkwQf_kgOTfrUFfrrQAIOloAPanX7Zyr7BANDlJk
CitedBy_id crossref_primary_10_1016_j_compositesb_2022_109623
crossref_primary_10_1016_j_ijbiomac_2022_10_134
crossref_primary_10_1016_j_cobme_2022_100394
crossref_primary_10_1016_j_fbp_2022_11_003
crossref_primary_10_1007_s44174_022_00055_8
crossref_primary_10_3390_microorganisms9091993
crossref_primary_10_1016_j_algal_2022_102939
crossref_primary_10_1016_j_carbpol_2023_121575
Cites_doi 10.1099/00222615-47-12-1081
10.1007/978-3-319-09782-4_7
10.1016/j.actbio.2015.11.010
10.1007/BF02931648
10.1016/j.urology.2006.06.008
10.1016/0143-7496(91)90035-G
10.1002/mabi.201000313
10.1016/j.carbpol.2019.115525
10.1016/j.fbp.2017.03.008
10.1046/j.1472-765X.1997.00378.x
10.1016/j.bej.2016.11.013
10.1002/bit.21838
10.1002/app.31499
10.1016/j.surfcoat.2019.125322
10.1016/j.colsurfb.2020.110976
10.1089/ten.tea.2007.0415
10.1016/j.surfcoat.2006.08.050
10.1073/pnas.1707572114
10.1111/lam.13144
10.1021/acsmacrolett.7b00879
10.1016/S0142-9612(03)00002-4
10.1016/j.actbio.2016.11.070
10.3390/md17040243
10.1016/j.biomaterials.2013.08.043
10.1126/science.1147241
10.1016/j.ijfoodmicro.2010.09.012
10.1039/c3tb21300e
10.1080/1040841X.2016.1240656
10.1016/j.ijpharm.2016.09.074
10.1099/jmm.0.000032
10.1016/j.colsurfb.2005.05.015
10.1002/app.26250
10.1002/pola.1993.080310426
10.1039/c3ib40130h
10.1002/mabi.201800384
10.1038/198799a0
10.1007/s11090-012-9394-8
10.3390/antibiotics9050216
10.1016/j.jhin.2013.06.015
10.1016/j.carbpol.2012.10.070
10.1021/acs.iecr.9b04828
10.1016/j.heliyon.2018.e01067
10.1016/j.polymertesting.2007.09.002
10.1111/j.1751-7915.2012.00359.x
10.1099/00221287-146-10-2395
10.1016/j.powtec.2018.11.079
10.1002/jbm.a.35245
10.1111/j.1574-695X.2007.00248.x
10.1016/j.procbio.2017.03.018
10.1163/156856195X01012
10.1163/156856299X00711
10.1007/s11595-014-0892-9
10.1111/jpy.12853
10.1002/1096-9918(200012)29:12<829::AID-SIA936>3.0.CO;2-M
10.1016/j.apsusc.2018.09.015
10.3390/ijms140918488
10.1002/app.32712
10.1016/j.colsurfb.2013.07.061
10.1021/bm900186s
10.1016/j.progpolymsci.2017.03.001
10.1002/mabi.201600206
10.1016/j.jcis.2011.03.066
10.1186/s40824-016-0064-4
10.1002/bit.23342
10.3390/md18060279
ContentType Journal Article
Copyright Copyright Royal Society of Chemistry 2021
Copyright_xml – notice: Copyright Royal Society of Chemistry 2021
DBID NPM
AAYXX
CITATION
7QF
7QO
7QQ
7SC
7SE
7SP
7SR
7TA
7TB
7U5
8BQ
8FD
F28
FR3
H8D
H8G
JG9
JQ2
KR7
L7M
L~C
L~D
P64
7X8
DOI 10.1039/d1tb00278c
DatabaseName PubMed
CrossRef
Aluminium Industry Abstracts
Biotechnology Research Abstracts
Ceramic Abstracts
Computer and Information Systems Abstracts
Corrosion Abstracts
Electronics & Communications Abstracts
Engineered Materials Abstracts
Materials Business File
Mechanical & Transportation Engineering Abstracts
Solid State and Superconductivity Abstracts
METADEX
Technology Research Database
ANTE: Abstracts in New Technology & Engineering
Engineering Research Database
Aerospace Database
Copper Technical Reference Library
Materials Research Database
ProQuest Computer Science Collection
Civil Engineering Abstracts
Advanced Technologies Database with Aerospace
Computer and Information Systems Abstracts – Academic
Computer and Information Systems Abstracts Professional
Biotechnology and BioEngineering Abstracts
MEDLINE - Academic
DatabaseTitle PubMed
CrossRef
Materials Research Database
Civil Engineering Abstracts
Aluminium Industry Abstracts
Technology Research Database
Computer and Information Systems Abstracts – Academic
Mechanical & Transportation Engineering Abstracts
Electronics & Communications Abstracts
ProQuest Computer Science Collection
Computer and Information Systems Abstracts
Ceramic Abstracts
Materials Business File
METADEX
Biotechnology and BioEngineering Abstracts
Computer and Information Systems Abstracts Professional
Aerospace Database
Copper Technical Reference Library
Engineered Materials Abstracts
Biotechnology Research Abstracts
Solid State and Superconductivity Abstracts
Engineering Research Database
Corrosion Abstracts
Advanced Technologies Database with Aerospace
ANTE: Abstracts in New Technology & Engineering
MEDLINE - Academic
DatabaseTitleList CrossRef
PubMed

Materials Research Database
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Engineering
Public Health
EISSN 2050-7518
EndPage 3715
ExternalDocumentID 10_1039_D1TB00278C
33871523
d1tb00278c
Genre Journal Article
GroupedDBID 0-7
0R
4.4
53G
705
AAEMU
AAGNR
AAIWI
AANOJ
ABASK
ABDVN
ABGFH
ABRYZ
ACGFS
ACIWK
ACLDK
ACPRK
ADMRA
ADSRN
AENEX
AFRAH
AFVBQ
AGRSR
AGSTE
AGSWI
ALMA_UNASSIGNED_HOLDINGS
ANUXI
ASKNT
AUDPV
BLAPV
BSQNT
C6K
CKLOX
D0L
EBS
ECGLT
EE0
EF-
GNO
HZ
H~N
J3I
JG
O-G
O9-
R7C
RCNCU
RIG
RNS
RPMJG
RRC
RSCEA
SKA
SKF
SLH
UCJ
-JG
0R~
AAJAE
AAWGC
AAXHV
ABEMK
ABJNI
ABPDG
ABXOH
AEFDR
AENGV
AESAV
AETIL
AFLYV
AFOGI
AFRDS
AGEGJ
AHGCF
APEMP
GGIMP
H13
HZ~
NPM
RAOCF
AAYXX
CITATION
7QF
7QO
7QQ
7SC
7SE
7SP
7SR
7TA
7TB
7U5
8BQ
8FD
F28
FR3
H8D
H8G
JG9
JQ2
KR7
L7M
L~C
L~D
P64
7X8
ID FETCH-LOGICAL-c400t-c490785d3be7de9a5d6d4cb4e8f17fab6a17df2155593999e1c7ef1facdce6243
ISSN 2050-750X
IngestDate Fri Oct 25 03:20:21 EDT 2024
Thu Oct 10 20:51:31 EDT 2024
Fri Aug 23 03:18:33 EDT 2024
Sat Sep 28 08:27:19 EDT 2024
Fri Apr 15 11:43:17 EDT 2022
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 17
Language English
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c400t-c490785d3be7de9a5d6d4cb4e8f17fab6a17df2155593999e1c7ef1facdce6243
Notes Electronic supplementary information (ESI) available: Contact angle (CA) measurements of PU surfaces subjected to different pDA incubation periods; CA measurements immediately after coating application and after 30 days storage in argon atmosphere; CA measurements of coatings exposed to accelerated degradation static conditions; XPS high resolution spectra of C1s of uncoated and activated PU; micrographs of bacterial cells adhered to uncoated and coated PU. See DOI
10.1039/d1tb00278c
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ORCID 0000-0003-4012-0069
0000-0002-2061-4697
0000-0001-8981-7049
OpenAccessLink http://hdl.handle.net/10216/133410
PMID 33871523
PQID 2522011500
PQPubID 2047522
PageCount 11
ParticipantIDs proquest_journals_2522011500
pubmed_primary_33871523
rsc_primary_d1tb00278c
proquest_miscellaneous_2515075965
crossref_primary_10_1039_D1TB00278C
PublicationCentury 2000
PublicationDate 20210505
PublicationDateYYYYMMDD 2021-05-05
PublicationDate_xml – month: 5
  year: 2021
  text: 20210505
  day: 5
PublicationDecade 2020
PublicationPlace England
PublicationPlace_xml – name: England
– name: Cambridge
PublicationTitle Journal of materials chemistry. B, Materials for biology and medicine
PublicationTitleAlternate J Mater Chem B
PublicationYear 2021
Publisher Royal Society of Chemistry
Publisher_xml – name: Royal Society of Chemistry
References Morra (D1TB00278C-(cit55)/*[position()=1]) 1999; 10
Heydorn (D1TB00278C-(cit46)/*[position()=1]) 2000; 146
Mareš (D1TB00278C-(cit35)/*[position()=1]) 2019; 55
Damodaran (D1TB00278C-(cit14)/*[position()=1]) 2016; 20
Kaplan (D1TB00278C-(cit29)/*[position()=1]) 1991; 11
Vladkova (D1TB00278C-(cit44)/*[position()=1]) 2020; 384
Costa (D1TB00278C-(cit20)/*[position()=1]) 2020; 18
Grainger (D1TB00278C-(cit8)/*[position()=1]) 2013; 34
Bernal (D1TB00278C-(cit68)/*[position()=1]) 2012; 5
Hebbar (D1TB00278C-(cit38)/*[position()=1]) 2017
Desrousseaux (D1TB00278C-(cit15)/*[position()=1]) 2013; 85
Junter (D1TB00278C-(cit16)/*[position()=1]) 2016; 30
Shi (D1TB00278C-(cit54)/*[position()=1]) 2009; 15
Huang (D1TB00278C-(cit9)/*[position()=1]) 2016; 17
Velraeds (D1TB00278C-(cit45)/*[position()=1]) 1998; 47
Weibel (D1TB00278C-(cit50)/*[position()=1]) 2006; 201
Mota (D1TB00278C-(cit26)/*[position()=1]) 2020; 229
Moreira (D1TB00278C-(cit63)/*[position()=1]) 2017; 104
Jiao (D1TB00278C-(cit71)/*[position()=1]) 2017; 71
Gomes (D1TB00278C-(cit43)/*[position()=1]) 2017; 57
Gadenne (D1TB00278C-(cit22)/*[position()=1]) 2013; 112
Lee (D1TB00278C-(cit34)/*[position()=1]) 2007; 318
Kong (D1TB00278C-(cit19)/*[position()=1]) 2010; 144
Khatoon (D1TB00278C-(cit7)/*[position()=1]) 2018; 4
Walzak (D1TB00278C-(cit49)/*[position()=1]) 1995; 9
Abourayana (D1TB00278C-(cit28)/*[position()=1]) 2015
Xu (D1TB00278C-(cit57)/*[position()=1]) 2011; 11
Lorite (D1TB00278C-(cit3)/*[position()=1]) 2011; 359
Loke (D1TB00278C-(cit21)/*[position()=1]) 2007; 50
Zander (D1TB00278C-(cit4)/*[position()=1]) 2018; 7
Jacobs (D1TB00278C-(cit51)/*[position()=1]) 2012; 35
Mishra (D1TB00278C-(cit69)/*[position()=1]) 2014; 2
Fujimoto (D1TB00278C-(cit32)/*[position()=1]) 1993; 118
Brooks (D1TB00278C-(cit40)/*[position()=1]) 1997; 24
Estevinho (D1TB00278C-(cit17)/*[position()=1]) 2019; 343
Pontes (D1TB00278C-(cit59)/*[position()=1]) 2016; 513
Singha (D1TB00278C-(cit64)/*[position()=1]) 2017; 50
Saeki (D1TB00278C-(cit23)/*[position()=1]) 1996; 37
Wang (D1TB00278C-(cit70)/*[position()=1]) 2020; 59
Ascencio (D1TB00278C-(cit24)/*[position()=1]) 2004; 49
Wang (D1TB00278C-(cit56)/*[position()=1]) 2012; 109
Yamada (D1TB00278C-(cit39)/*[position()=1]) 1963; 198
Haack (D1TB00278C-(cit48)/*[position()=1]) 2000; 29
Azevedo (D1TB00278C-(cit61)/*[position()=1]) 2017; 43
Alves (D1TB00278C-(cit66)/*[position()=1]) 2020; 191
Costa (D1TB00278C-(cit13)/*[position()=1]) 2019; 17
Gadenne (D1TB00278C-(cit65)/*[position()=1]) 2015; 103
Martins (D1TB00278C-(cit37)/*[position()=1]) 2003; 24
Percival (D1TB00278C-(cit2)/*[position()=1]) 2015; 64
Chen (D1TB00278C-(cit5)/*[position()=1]) 2013; 14
Francolini (D1TB00278C-(cit6)/*[position()=1]) 2015; 831
Sanchis (D1TB00278C-(cit52)/*[position()=1]) 2008; 27
Bračič (D1TB00278C-(cit58)/*[position()=1]) 2019; 463
Sanchis (D1TB00278C-(cit30)/*[position()=1]) 2007; 105
Alves (D1TB00278C-(cit67)/*[position()=1]) 2020; 9
Lin (D1TB00278C-(cit53)/*[position()=1]) 2005; 44
Zhou (D1TB00278C-(cit10)/*[position()=1]) 2010; 116
Mota (D1TB00278C-(cit25)/*[position()=1]) 2013; 92
Ramstedt (D1TB00278C-(cit11)/*[position()=1]) 2019; 19
Rippka (D1TB00278C-(cit36)/*[position()=1]) 1979; 111
Bryers (D1TB00278C-(cit1)/*[position()=1]) 2008; 100
Jiang (D1TB00278C-(cit47)/*[position()=1]) 2014; 29
Koseoglu (D1TB00278C-(cit41)/*[position()=1]) 2006; 68
Desmet (D1TB00278C-(cit31)/*[position()=1]) 2009; 10
Azevedo (D1TB00278C-(cit42)/*[position()=1]) 2017; 118
Swiecicki (D1TB00278C-(cit60)/*[position()=1]) 2013; 5
Pelling (D1TB00278C-(cit27)/*[position()=1]) 2019; 68
Kuang (D1TB00278C-(cit33)/*[position()=1]) 2010; 118
Walker (D1TB00278C-(cit62)/*[position()=1]) 2017; 114
Leite (D1TB00278C-(cit18)/*[position()=1]) 2017; 17
Xu (D1TB00278C-(cit12)/*[position()=1]) 2016
References_xml – issn: 2015
  end-page: p 123-152
  publication-title: Surface Energy
  doi: Abourayana Dowling
– issn: 2016
  end-page: p 247-284
  publication-title: Advances in Polyurethane Biomaterials
  doi: Xu Siedlecki
– issn: 2017
  end-page: p 219-225
  publication-title: Membrane Characterization
  doi: Hebbar Isloor Ismail
– volume: 47
  start-page: 1081
  year: 1998
  ident: D1TB00278C-(cit45)/*[position()=1]
  publication-title: J. Med. Microbiol.
  doi: 10.1099/00222615-47-12-1081
  contributor:
    fullname: Velraeds
– volume: 831
  start-page: 93
  year: 2015
  ident: D1TB00278C-(cit6)/*[position()=1]
  publication-title: Adv. Exp. Med. Biol.
  doi: 10.1007/978-3-319-09782-4_7
  contributor:
    fullname: Francolini
– volume: 30
  start-page: 13
  year: 2016
  ident: D1TB00278C-(cit16)/*[position()=1]
  publication-title: Acta Biomater.
  doi: 10.1016/j.actbio.2015.11.010
  contributor:
    fullname: Junter
– volume: 49
  start-page: 64
  year: 2004
  ident: D1TB00278C-(cit24)/*[position()=1]
  publication-title: Folia Microbiol.
  doi: 10.1007/BF02931648
  contributor:
    fullname: Ascencio
– volume: 68
  start-page: 942
  year: 2006
  ident: D1TB00278C-(cit41)/*[position()=1]
  publication-title: Urology
  doi: 10.1016/j.urology.2006.06.008
  contributor:
    fullname: Koseoglu
– volume: 11
  start-page: 109
  year: 1991
  ident: D1TB00278C-(cit29)/*[position()=1]
  publication-title: Int. J. Adhes. Adhes.
  doi: 10.1016/0143-7496(91)90035-G
  contributor:
    fullname: Kaplan
– volume: 11
  start-page: 257
  year: 2011
  ident: D1TB00278C-(cit57)/*[position()=1]
  publication-title: Macromol. Biosci.
  doi: 10.1002/mabi.201000313
  contributor:
    fullname: Xu
– volume: 229
  start-page: 115525
  year: 2020
  ident: D1TB00278C-(cit26)/*[position()=1]
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2019.115525
  contributor:
    fullname: Mota
– volume: 104
  start-page: 1
  year: 2017
  ident: D1TB00278C-(cit63)/*[position()=1]
  publication-title: Food Bioprod. Process.
  doi: 10.1016/j.fbp.2017.03.008
  contributor:
    fullname: Moreira
– volume: 24
  start-page: 203
  year: 1997
  ident: D1TB00278C-(cit40)/*[position()=1]
  publication-title: Lett. Appl. Microbiol.
  doi: 10.1046/j.1472-765X.1997.00378.x
  contributor:
    fullname: Brooks
– volume: 118
  start-page: 64
  year: 2017
  ident: D1TB00278C-(cit42)/*[position()=1]
  publication-title: Biochem. Eng. J.
  doi: 10.1016/j.bej.2016.11.013
  contributor:
    fullname: Azevedo
– volume: 100
  start-page: 1
  year: 2008
  ident: D1TB00278C-(cit1)/*[position()=1]
  publication-title: Biotechnol. Bioeng.
  doi: 10.1002/bit.21838
  contributor:
    fullname: Bryers
– volume: 116
  start-page: 1284
  year: 2010
  ident: D1TB00278C-(cit10)/*[position()=1]
  publication-title: J. Appl. Polym. Sci.
  doi: 10.1002/app.31499
  contributor:
    fullname: Zhou
– volume: 384
  start-page: 125322
  year: 2020
  ident: D1TB00278C-(cit44)/*[position()=1]
  publication-title: Surf. Coat. Technol.
  doi: 10.1016/j.surfcoat.2019.125322
  contributor:
    fullname: Vladkova
– volume: 191
  start-page: 110976
  year: 2020
  ident: D1TB00278C-(cit66)/*[position()=1]
  publication-title: Colloids Surf., B
  doi: 10.1016/j.colsurfb.2020.110976
  contributor:
    fullname: Alves
– volume-title: Surface Energy
  year: 2015
  ident: D1TB00278C-(cit28)/*[position()=1]
  contributor:
    fullname: Abourayana
– volume: 15
  start-page: 417
  year: 2009
  ident: D1TB00278C-(cit54)/*[position()=1]
  publication-title: Tissue Eng., Part A
  doi: 10.1089/ten.tea.2007.0415
  contributor:
    fullname: Shi
– volume: 201
  start-page: 4190
  year: 2006
  ident: D1TB00278C-(cit50)/*[position()=1]
  publication-title: Surf. Coat. Technol.
  doi: 10.1016/j.surfcoat.2006.08.050
  contributor:
    fullname: Weibel
– volume: 114
  start-page: E8721
  year: 2017
  ident: D1TB00278C-(cit62)/*[position()=1]
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.1707572114
  contributor:
    fullname: Walker
– volume: 68
  start-page: 277
  year: 2019
  ident: D1TB00278C-(cit27)/*[position()=1]
  publication-title: Lett. Appl. Microbiol.
  doi: 10.1111/lam.13144
  contributor:
    fullname: Pelling
– volume: 7
  start-page: 16
  year: 2018
  ident: D1TB00278C-(cit4)/*[position()=1]
  publication-title: ACS Macro Lett.
  doi: 10.1021/acsmacrolett.7b00879
  contributor:
    fullname: Zander
– volume: 24
  start-page: 2067
  year: 2003
  ident: D1TB00278C-(cit37)/*[position()=1]
  publication-title: Biomaterials
  doi: 10.1016/S0142-9612(03)00002-4
  contributor:
    fullname: Martins
– volume: 50
  start-page: 20
  year: 2017
  ident: D1TB00278C-(cit64)/*[position()=1]
  publication-title: Acta Biomater.
  doi: 10.1016/j.actbio.2016.11.070
  contributor:
    fullname: Singha
– volume: 17
  start-page: 243
  year: 2019
  ident: D1TB00278C-(cit13)/*[position()=1]
  publication-title: Mar. Drugs
  doi: 10.3390/md17040243
  contributor:
    fullname: Costa
– volume: 34
  start-page: 9237
  year: 2013
  ident: D1TB00278C-(cit8)/*[position()=1]
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2013.08.043
  contributor:
    fullname: Grainger
– volume: 318
  start-page: 426
  year: 2007
  ident: D1TB00278C-(cit34)/*[position()=1]
  publication-title: Science
  doi: 10.1126/science.1147241
  contributor:
    fullname: Lee
– volume: 144
  start-page: 51
  year: 2010
  ident: D1TB00278C-(cit19)/*[position()=1]
  publication-title: Int. J. Food Microbiol.
  doi: 10.1016/j.ijfoodmicro.2010.09.012
  contributor:
    fullname: Kong
– volume: 2
  start-page: 1706
  year: 2014
  ident: D1TB00278C-(cit69)/*[position()=1]
  publication-title: J. Mater. Chem. B
  doi: 10.1039/c3tb21300e
  contributor:
    fullname: Mishra
– volume: 43
  start-page: 423
  year: 2017
  ident: D1TB00278C-(cit61)/*[position()=1]
  publication-title: Crit. Rev. Microbiol.
  doi: 10.1080/1040841X.2016.1240656
  contributor:
    fullname: Azevedo
– volume: 513
  start-page: 697
  year: 2016
  ident: D1TB00278C-(cit59)/*[position()=1]
  publication-title: Int. J. Pharm.
  doi: 10.1016/j.ijpharm.2016.09.074
  contributor:
    fullname: Pontes
– volume: 64
  start-page: 323
  year: 2015
  ident: D1TB00278C-(cit2)/*[position()=1]
  publication-title: J. Med. Microbiol.
  doi: 10.1099/jmm.0.000032
  contributor:
    fullname: Percival
– volume: 44
  start-page: 82
  year: 2005
  ident: D1TB00278C-(cit53)/*[position()=1]
  publication-title: Colloids Surf., B
  doi: 10.1016/j.colsurfb.2005.05.015
  contributor:
    fullname: Lin
– volume: 105
  start-page: 1077
  year: 2007
  ident: D1TB00278C-(cit30)/*[position()=1]
  publication-title: J. Appl. Polym. Sci.
  doi: 10.1002/app.26250
  contributor:
    fullname: Sanchis
– volume: 118
  start-page: 1035
  year: 1993
  ident: D1TB00278C-(cit32)/*[position()=1]
  publication-title: J. Polym. Sci., Part A: Polym. Chem.
  doi: 10.1002/pola.1993.080310426
  contributor:
    fullname: Fujimoto
– volume: 5
  start-page: 1490
  year: 2013
  ident: D1TB00278C-(cit60)/*[position()=1]
  publication-title: Integr. Biol.
  doi: 10.1039/c3ib40130h
  contributor:
    fullname: Swiecicki
– volume: 19
  start-page: e1800384
  year: 2019
  ident: D1TB00278C-(cit11)/*[position()=1]
  publication-title: Macromol. Biosci.
  doi: 10.1002/mabi.201800384
  contributor:
    fullname: Ramstedt
– volume: 198
  start-page: 799
  year: 1963
  ident: D1TB00278C-(cit39)/*[position()=1]
  publication-title: Nature
  doi: 10.1038/198799a0
  contributor:
    fullname: Yamada
– volume-title: Advances in Polyurethane Biomaterials
  year: 2016
  ident: D1TB00278C-(cit12)/*[position()=1]
  contributor:
    fullname: Xu
– volume: 35
  start-page: 1039
  year: 2012
  ident: D1TB00278C-(cit51)/*[position()=1]
  publication-title: Plasma Chem. Plasma Process.
  doi: 10.1007/s11090-012-9394-8
  contributor:
    fullname: Jacobs
– volume: 9
  start-page: 216
  year: 2020
  ident: D1TB00278C-(cit67)/*[position()=1]
  publication-title: Antibiotics
  doi: 10.3390/antibiotics9050216
  contributor:
    fullname: Alves
– volume: 85
  start-page: 87
  year: 2013
  ident: D1TB00278C-(cit15)/*[position()=1]
  publication-title: J. Hosp. Infect.
  doi: 10.1016/j.jhin.2013.06.015
  contributor:
    fullname: Desrousseaux
– volume: 92
  start-page: 1408
  year: 2013
  ident: D1TB00278C-(cit25)/*[position()=1]
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2012.10.070
  contributor:
    fullname: Mota
– volume: 59
  start-page: 458
  year: 2020
  ident: D1TB00278C-(cit70)/*[position()=1]
  publication-title: Ind. Eng. Chem. Res.
  doi: 10.1021/acs.iecr.9b04828
  contributor:
    fullname: Wang
– volume: 4
  start-page: e01067
  year: 2018
  ident: D1TB00278C-(cit7)/*[position()=1]
  publication-title: Heliyon
  doi: 10.1016/j.heliyon.2018.e01067
  contributor:
    fullname: Khatoon
– volume: 27
  start-page: 75
  year: 2008
  ident: D1TB00278C-(cit52)/*[position()=1]
  publication-title: Polym. Test.
  doi: 10.1016/j.polymertesting.2007.09.002
  contributor:
    fullname: Sanchis
– volume-title: Membrane Characterization
  year: 2017
  ident: D1TB00278C-(cit38)/*[position()=1]
  contributor:
    fullname: Hebbar
– volume: 5
  start-page: 670
  year: 2012
  ident: D1TB00278C-(cit68)/*[position()=1]
  publication-title: Microbiol. Biotechnol.
  doi: 10.1111/j.1751-7915.2012.00359.x
  contributor:
    fullname: Bernal
– volume: 111
  start-page: 1
  year: 1979
  ident: D1TB00278C-(cit36)/*[position()=1]
  publication-title: J. Gen. Microbiol.
  contributor:
    fullname: Rippka
– volume: 146
  start-page: 2395
  year: 2000
  ident: D1TB00278C-(cit46)/*[position()=1]
  publication-title: Microbiology
  doi: 10.1099/00221287-146-10-2395
  contributor:
    fullname: Heydorn
– volume: 343
  start-page: 644
  year: 2019
  ident: D1TB00278C-(cit17)/*[position()=1]
  publication-title: Powder Technol.
  doi: 10.1016/j.powtec.2018.11.079
  contributor:
    fullname: Estevinho
– volume: 103
  start-page: 1021
  year: 2015
  ident: D1TB00278C-(cit65)/*[position()=1]
  publication-title: J. Biomed. Mater. Res., Part A
  doi: 10.1002/jbm.a.35245
  contributor:
    fullname: Gadenne
– volume: 50
  start-page: 231
  year: 2007
  ident: D1TB00278C-(cit21)/*[position()=1]
  publication-title: FEMS Immunol. Med. Microbiol.
  doi: 10.1111/j.1574-695X.2007.00248.x
  contributor:
    fullname: Loke
– volume: 57
  start-page: 1
  year: 2017
  ident: D1TB00278C-(cit43)/*[position()=1]
  publication-title: Process Biochem.
  doi: 10.1016/j.procbio.2017.03.018
  contributor:
    fullname: Gomes
– volume: 37
  start-page: 77
  year: 1996
  ident: D1TB00278C-(cit23)/*[position()=1]
  publication-title: Bull. Tokyo Dent. Coll.
  contributor:
    fullname: Saeki
– volume: 9
  start-page: 1229
  year: 1995
  ident: D1TB00278C-(cit49)/*[position()=1]
  publication-title: J. Adhes. Sci. Technol.
  doi: 10.1163/156856195X01012
  contributor:
    fullname: Walzak
– volume: 10
  start-page: 1107
  year: 1999
  ident: D1TB00278C-(cit55)/*[position()=1]
  publication-title: J. Biomater. Sci., Polym. Ed.
  doi: 10.1163/156856299X00711
  contributor:
    fullname: Morra
– volume: 29
  start-page: 197
  year: 2014
  ident: D1TB00278C-(cit47)/*[position()=1]
  publication-title: J. Wuhan Univ. Technol. Mater. Sci. Ed.
  doi: 10.1007/s11595-014-0892-9
  contributor:
    fullname: Jiang
– volume: 55
  start-page: 1076
  year: 2019
  ident: D1TB00278C-(cit35)/*[position()=1]
  publication-title: J. Phycol.
  doi: 10.1111/jpy.12853
  contributor:
    fullname: Mareš
– volume: 29
  start-page: 829
  year: 2000
  ident: D1TB00278C-(cit48)/*[position()=1]
  publication-title: Surf. Interface Anal.
  doi: 10.1002/1096-9918(200012)29:12<829::AID-SIA936>3.0.CO;2-M
  contributor:
    fullname: Haack
– volume: 463
  start-page: 889
  year: 2019
  ident: D1TB00278C-(cit58)/*[position()=1]
  publication-title: Appl. Surf. Sci.
  doi: 10.1016/j.apsusc.2018.09.015
  contributor:
    fullname: Bračič
– volume: 14
  start-page: 18488
  year: 2013
  ident: D1TB00278C-(cit5)/*[position()=1]
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms140918488
  contributor:
    fullname: Chen
– volume: 118
  start-page: 3024
  year: 2010
  ident: D1TB00278C-(cit33)/*[position()=1]
  publication-title: J. Appl. Polym. Sci.
  doi: 10.1002/app.32712
  contributor:
    fullname: Kuang
– volume: 17
  start-page: 1
  year: 2016
  ident: D1TB00278C-(cit9)/*[position()=1]
  publication-title: Int. J. Mol. Sci.
  contributor:
    fullname: Huang
– volume: 112
  start-page: 229
  year: 2013
  ident: D1TB00278C-(cit22)/*[position()=1]
  publication-title: Colloids Surf., B
  doi: 10.1016/j.colsurfb.2013.07.061
  contributor:
    fullname: Gadenne
– volume: 10
  start-page: 2351
  year: 2009
  ident: D1TB00278C-(cit31)/*[position()=1]
  publication-title: Biomacromolecules
  doi: 10.1021/bm900186s
  contributor:
    fullname: Desmet
– volume: 71
  start-page: 53
  year: 2017
  ident: D1TB00278C-(cit71)/*[position()=1]
  publication-title: Prog. Polym. Sci.
  doi: 10.1016/j.progpolymsci.2017.03.001
  contributor:
    fullname: Jiao
– volume: 17
  start-page: 1600206
  year: 2017
  ident: D1TB00278C-(cit18)/*[position()=1]
  publication-title: Macromol. Biosci.
  doi: 10.1002/mabi.201600206
  contributor:
    fullname: Leite
– volume: 359
  start-page: 289
  year: 2011
  ident: D1TB00278C-(cit3)/*[position()=1]
  publication-title: J. Colloid Interface Sci.
  doi: 10.1016/j.jcis.2011.03.066
  contributor:
    fullname: Lorite
– volume: 20
  start-page: 1
  year: 2016
  ident: D1TB00278C-(cit14)/*[position()=1]
  publication-title: Biomater. Res.
  doi: 10.1186/s40824-016-0064-4
  contributor:
    fullname: Damodaran
– volume: 109
  start-page: 336
  year: 2012
  ident: D1TB00278C-(cit56)/*[position()=1]
  publication-title: Biotechnol. Bioeng.
  doi: 10.1002/bit.23342
  contributor:
    fullname: Wang
– volume: 18
  start-page: 1
  year: 2020
  ident: D1TB00278C-(cit20)/*[position()=1]
  publication-title: Mar. Drugs
  doi: 10.3390/md18060279
  contributor:
    fullname: Costa
SSID ssj0000816834
Score 2.2407374
Snippet Hospital-acquired infections are still a major concern worldwide, being frequently related to bacterial biofilm formation on medical devices, and thus...
SourceID proquest
crossref
pubmed
rsc
SourceType Aggregation Database
Index Database
Publisher
StartPage 375
SubjectTerms Antibiotics
Antiinfectives and antibacterials
Argon
Bacteria
Biodegradation
Biofilms
Coatings
Contact angle
E coli
Etiology
Immobilization
Industrial applications
Infections
Medical equipment
Natural polymers
Nitrogen plasma
Nosocomial infections
Ozone
Photomicrographs
Polymer coatings
Polymers
Polyurethane
Polyurethane resins
Public health
Substrates
Surface activation
Urinary tract
Urogenital system
Title Surface activation of medical grade polyurethane for the covalent immobilization of an anti-adhesive biopolymeric coating
URI https://www.ncbi.nlm.nih.gov/pubmed/33871523
https://www.proquest.com/docview/2522011500
https://search.proquest.com/docview/2515075965
Volume 9
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Nb9MwFLfKdoED4mvQMZAR3KaMJE7i5riVjoHacSCVeosc29l6oEFdMqn7d_hHef6Ik1IOg4uV2rXj-P1s_2w_v4fQh9AXlCQB88JEJF4UyAL6XBp6IhZAZpMiDbR1_dllcjGPvi7ixWDwq6e11NTFCb_7672S_5EqxIFc1S3Zf5CsKxQi4BnkCyFIGMJ7yfh7sy4ZNwYxbh33-2HPXq7WTEjlhWHTrKXaIZdOp5BXUA2lBbCEyir12DuXmynt5HrpMXEtjWr7UvlR2Bide16xup3sdiktsF_z2ce89SN3cnxmrgS1KVo9tGf56c_D_Zl6wTXzxgDd6sacC6lte5deWb67rN2M8rmy1yqmjdqkYd3Wr0uZKWeLrL_HEQZao9Acdks9FoZ-7HvqhKg_cKd9fNLeKExom9n-NDdGd2YLnyhjqyLQvkrpiHdzYqsHcPktP59Pp3k2WWQP0H4IoxkMo_unk-zL1G3lad8lJGqN35L0Y1fkNt3ZWcMAo1m3nmY0o8meoMdWbvjU4OopGsjVM_SoZ6DyOdpYhOEOYbgqsUUY1gjDfYRhEC8GhOEWYXgbYSo3W-EthOE-wrBF2As0P59k4wvPOuvwOEwDNYQpsM1YkEJSIVMWi0REvIjkqAxoyYqEBVSUQDBhCQukOJUBp7IM4BsEl0kYkQO0t6pW8hXCnJUxpWU0KgrglyXMGD6ngsHCw5e0FGSI3rdtmv80NllyrUtB0vxTkJ3plh8P0VHb3Lntszd5CMsNvQjyh-idS4YOoY7JoJWqRv1HLZLiNImH6KURk3sNISMAUwhVOAC5uehO3of3KPY1etiB_Ajt1etGvgFqWxdvLbR-A9Onry4
link.rule.ids 315,783,787,27936,27937
linkProvider Royal Society of Chemistry
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Surface+activation+of+medical+grade+polyurethane+for+the+covalent+immobilization+of+an+anti-adhesive+biopolymeric+coating&rft.jtitle=Journal+of+materials+chemistry.+B%2C+Materials+for+biology+and+medicine&rft.au=Matinha-Cardoso%2C+Jorge&rft.au=Mota%2C+Rita&rft.au=Gomes%2C+Luciana+C&rft.au=Gomes%2C+Marisa&rft.date=2021-05-05&rft.eissn=2050-7518&rft.volume=9&rft.issue=17&rft.spage=3705&rft.epage=3715&rft_id=info:doi/10.1039%2Fd1tb00278c&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2050-750X&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2050-750X&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2050-750X&client=summon